A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility
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Enzyme Inhibitors -- chemistry : Evaluation of enzyme inhibitors in drug discovery : a guide for medicinal chemists and pharmacologists / by Robert A. Copeland
Enzyme Inhibitors -- pharmacology. : Protein surface recognition : approaches for drug discovery / edited by Ernest Giralt, Mark W. Peczuh, Xavier Salvatella
