Founder Effect. : Founder mutations in inherited cardiac diseases in the Netherlands / edited by Arthur A.M. Wilde, J. Peter Tintelen ; with a preface of H.J. Wellens
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive
