| Description |
1 online resource (xix, 466 pages) : illustrations |
| Series |
Nucleic acids and molecular biology ; 24 |
|
Nucleic acids and molecular biology ; v. 24
|
| Contents |
Cover -- Contents -- Part I: Redefinition -- 1 Selenocysteine Biosynthesis, Selenoproteins, and Selenoproteomes -- 2 Reprogramming the Ribosome for Selenoprotein Expression: RNA Elements and Protein Factors -- 3 Translation of UAG as Pyrrolysine -- 4 Specification of Standard Amino Acids by Stop Codons -- 5 Ribosome Skipping: Stop-Carry On or StopGo Translation -- 6 Recoding Therapies for Genetic Diseases -- Part II: Frameshifting Redirection of Linear Readout -- 7 Pseudoknot-Dependent Programmed 1 Ribosomal Frameshifting: Structures, Mechanisms and Models -- 8 Programmed 1 Ribosomal Frameshift in the Human Immunodeficiency Virus of Type 1 -- 9 Ribosomal Frameshifting in Decoding Plant Viral RNAs -- 10 Programmed Frameshifting in Budding Yeast -- 11 Recoding in Bacteriophages -- 12 Programmed Ribosomal -- 1 Frameshifting as a Tradition: The Bacterial Transposable Elements of the IS3 Family -- 13 Autoregulatory Frameshifting in Antizyme Gene Expression Governs Polyamine Levels from Yeast to Mammals -- 14 Sequences Promoting Recoding Are Singular Genomic Elements -- 15 Mutants That Affect Recoding -- 16 The E Site and Its Importance for Improving Accuracy and Preventing Frameshifts -- Part III: Discontiguity -- 17 Translational Bypassing Peptidyl-tRNA Re-pairing at Non-overlapping Sites -- 18 trans -Translation -- Part IV: Transcription Slippage -- 19 Transcript Slippage and Recoding -- Part V: Appendix -- 20 Computational Resources for Studying Recoding -- Index |
| Summary |
The dynamic nature of decoding the information in messenger RNA was unanticipated at the time the genetic code was first deciphered. We now know that both the meaning of individual codons and the framing of the readout process can be modified by information in specific messenger RNAs. This book describes this "Recoding" phenomenon, revealing the diversity of an additional layer of information in mRNAs that serves to enrich the expression of genes. Knowledge of recoding is essential for understanding the organization and expression of genes in viruses and all organisms ranging from bacteria to archeae to plants to humans, making Recoding pertinent to all biological sciences |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Genetic code.
|
|
Messenger RNA.
|
|
RNA editing.
|
|
Genetic regulation.
|
|
Gene expression.
|
|
Genetic Code
|
|
Frameshifting, Ribosomal
|
|
Gene Expression
|
|
Molecular Sequence Data
|
|
RNA, Messenger -- genetics
|
|
Gene Expression Regulation
|
|
SCIENCE -- Life Sciences -- Biochemistry.
|
|
Biomédecine.
|
|
Sciences de la vie.
|
|
Gene expression
|
|
Genetic code
|
|
Genetic regulation
|
|
Messenger RNA
|
|
RNA editing
|
| Form |
Electronic book
|
| Author |
Atkins, John F. (John Fuller)
|
|
Gesteland, Raymond F
|
| ISBN |
9780387893822 |
|
0387893822 |
|
