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Title Polycomb group proteins / edited by Vincenzo Pirrotta
Published London : Academic Press, 2017
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Description 1 online resource
Series Translational epigenetics series
Translational epigenetics series.
Contents Front Cover; Polycomb Group Proteins; Translational Epigenetics Series; Polycomb Group Proteins; Copyright; Contents; List of Contributors; Editor's Biography; Acknowledgments; 1 -- Introduction to Polycomb Group Mechanisms; REFERENCES; 2 -- The Role of RAWUL and SAM in Polycomb Repression Complex 1 Assembly and Function; INTRODUCTION; POLYCOMB GROUP; POLYCOMB GROUP RAWUL; Structural Basis for RAWUL-Binding Selectivity; RAWUL Heterodimerization as a Template for Additional Interactions; Internal Tandem Duplications in BCOR PUFD Found in Tumors; POLYCOMB GROUP SAMS
Ph SAM Polymerization Is Required for FunctionPh SAM Polymerization Is Required for Subnuclear Organization of PRC1; What Is the Stoichiometry of SAM-Polymerized PRC1?; SAM Polymer Regulation; How Does Ph SAM Polymerization Affect PRC1 H2Aub Activity?; Scm SAM-Dependent Repression; SUMMARY; LIST OF ACRONYMS AND ABBREVIATIONS; ACKNOWLEDGMENTS; REFERENCES; 3 -- The Chromodomain of Polycomb: Methylation Reader and Beyond; INTRODUCTION; POLYCOMB CHROMODOMAIN SPECIFICALLY RECOGNIZES H3K27ME3; STRUCTURAL BASIS FOR THE POLYCOMB-H3K27ME3 INTERACTION SPECIFICITY
MAMMALIAN POLYCOMB HOMOLOGS BIND DIFFERENTIALLY TO METHYLATED HISTONE H3CROSS TALK BETWEEN HISTONE METHYLATION AND OTHER POSTTRANSLATIONAL MODIFICATIONS; PUTATIVE NONHISTONE TARGETS OF POLYCOMB GROUP CHROMODOMAINS; NONCODING RNA: NONCANONICAL PARTNERS OF POLYCOMB GROUP CHROMODOMAINS; CHEMICAL PROBES FOR CBX7 CHROMODOMAIN; POLYCOMB HOMOLOGS FROM YEAST AND PLANT: EVOLUTIONARILY CONSERVED BIOLOGICAL SIGNIFICANCE OF CHROMODOMAIN; CONCLUSION; LIST OF ACRONYMS AND ABBREVIATIONS; GLOSSARY; REFERENCES; 4 -- Unraveling the Roles of Canonical and Noncanonical PRC1 Complexes; BACKGROUND
THE MECHANISM OF ACTION OF CANONICAL POLYCOMB REPRESSIVE COMPLEXES 1THE MECHANISM OF ACTION OF NONCANONICAL POLYCOMB REPRESSIVE COMPLEXES 1; THE BIOLOGICAL IMPORTANCE OF CANONICAL POLYCOMB REPRESSIVE COMPLEX 1, NONCANONICAL POLYCOMB REPRESSIVE COMPLEX 1, AND H2A M ... ; PERSPECTIVES; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES; 5 -- Structure and Biochemistry of the Polycomb Repressive Complex 1 Ubiquitin Ligase Module; INTRODUCTION; UBIQUITIN CONJUGATION AND DECONJUGATION; PRC1 IS A RING E3 LIGASE; THE ACTIVE E3 LIGASE IS A HETERODIMER OF BMI1 AND RING1
BIOCHEMICAL AND STRUCTURAL STUDIES OF THE RING DOMAINS OF THE BMI1-RING1B HETERODIMERRECOGNITION OF E2 ENZYMES BY BMI1-RING1B; INTERACTION OF BMI1-RING1B-UBCH5C WITH SUBSTRATE; STRUCTURE OF THE PRC1 UBIQUITIN LIGASE MODULE BOUND TO NUCLEOSOME; VARIANT PRC1 COMPLEXES AND THE MECHANISM OF UBIQUITIN TRANSFER; WHICH PRC1 CONTRIBUTES MOST TO H2A UBIQUITINATION?; IS H2A UBIQUITINATION REALLY IMPORTANT?; WHAT DOES UH2A DO?; WHAT'S NEXT FOR PRC1 AND UH2A?; REFERENCES; 6 -- Cooperative Recruitment of Polycomb Complexes by Polycomb Response Elements; INTRODUCTION; POLYCOMB GROUP PROTEIN COMPLEXES
Bibliography Includes bibliographical references and index
Notes Online resource, title from PDF title page (EBSCO, viewed January 28, 2017)
Subject Proteins.
Polycomb-Group Proteins
protein.
SCIENCE -- Life Sciences -- Biochemistry.
Proteins.
Genre/Form Electronic books
Form Electronic book
Author Pirrotta, Vincenzo, editor
LC no. 2016960459
ISBN 9780128098226
0128098228