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Title RAMPs / edited by William S. Spielman, Narayanan Parameswaran
Published New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2012


Description 1 online resource (xvii, 114 pages) : illustrations
Series Advances in experimental medicine and biology ; v. 744
Advances in experimental medicine and biology ; v. 744. 0065-2598
Contents Introduction to Ramps / Narayanan Parameswaran and William S. Spielman -- RAMPs and CGRP Receptors / James Barwell, Denise Wootten, John Simms, Debbie L. Hay and David R. Poyner -- Regulation of GPCR Trafficking by RAMPs / Jennifer M. Bomberger, Narayanan Parameswaran and William S. Spielman -- Regulation of Calcium Sensing Receptor Trafficking by RAMPs / Tristan Bouschet, Stéphane Martin and Jeremy M. Henley -- Understanding RAMPs Through Genetically Engineered Mouse Models / Mahita Kadmiel, Kimberly L. Fritz-Six and Kathleen M. Caron -- RAMPs as Drug Targets / Patrick M. Sexton, David R. Poyner, John Simms, Arthur Christopoulos and Debbie L. Hay -- Ramp Like Proteins / RTP and REEP Family of Proteins / Joel Mainland and Hiroaki Matsunami -- Regulation of RAMP Expression in Diseases / Asha Jacob, Rongqian Wu and Ping Wang -- Perspectives on Some Recent Studies on RAMPs / Narayanan Parameswaran and William S. Spielman
Summary Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years
Analysis celbiologie
cellular biology
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject G proteins -- Receptors
Receptor Activity-Modifying Proteins
SCIENCE -- Life Sciences -- Biochemistry.
G proteins -- Receptors
Form Electronic book
Author Spielman, William S., 1947-
Parameswaran, Narayanan, 1970-
ISBN 9781461423645