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Title Neurosteroid effects in the central nervous system : the role of the GABA-A receptor / [edited by] Sheryl S. Smith
Published Boca Raton : CRC Press, ©2004


Description 1 online resource (379 pages) : illustrations (some color)
Series Methods & new frontiers in neuroscience
Methods & new frontiers in neuroscience series.
Contents Introduction <br>Synthesis, enzyme localization, and regulation of neurosteroids, <br><i>Synthia H. Mellon</i> <br>Subunit specificity of steroid modulation of GABA<sub>A</sub> receptors, <i>R.W. Olsen, E. Cagetti and M. Wallner</i> <br>THDOC and the GABA-A receptor, <i> S. Vicini</i> <br>Neurosteoid modulation of delta subunit-containing GABA<sub>A </sub>receptor channels, <i>M.T. Bianchi and R.L. Macdonald</i> <br>Potentiation and inhibition of GABA<sub>A</sub> receptor function by neuroactive steroids, <i>L.N. Eisenman, Y. He, D.F. Covey, C.F. Zorumski, S. Zorumski, and S. Mennerick</i> <br>Anabolic androgenic steroids and the brain: Novel actions at the GABA<sub>A</sub> receptor and on GABA<sub>A</sub> receptor mediated behaviors, <i>A.S. Clark, B.L. Jones, P. Yang, and L. Henderson</i> <br>Withdrawal effects of a neuroactive steroid as a model of PMS: Synaptic physiology to behavior, <i>S. Smith</i> <br>GABA, estrogen, and sex differences in the brain, <i>M.M. McCarthy, J.L. Nunez, and T.S. Perrot-Sinal</i> <br>FGIN-1-X -- A series of novel specific and efficacious ligands for the peripheral benzodiazepine receptor, <i>E, M. Skowronski-Lutz and D, Bitran</i> <br>GABAergic neuroactive steroids modulate selective ethanol actions: mechanisms and significance, <i>A.L, Morrow, R, Khisti, S, Tokunaga, J, R. McDaniel, and D.B. Matthews</i> <br>Allopregnanolone modulates the action of ethanol and stress on the activity of mesocortical dopaminergic neurons and HPA axis, <i>G. Biggio, L. Dazzi, and M. Serra</i> <br>3a, 5a-THP's actions in the ventral tegmental area for lordosis: A model system for defining mechanisms and function of progestins, <i>C.A. Frye and S.M. Petralia</i> <br>Premenstrual dysphoric disorder, <i>I. Sundstrom-Poromaa</i> <br>Role of neurosteroids in epilepsy, <i>Z. Mtchedlishvili and J. Kapur</i> <br>Animal models of anxiety and stress-induced behavior: Effects of neuroactive steroids, <i>D.A. Finn, R.H. Purdy and G.F. Koob</i> <br>Direct modulation of amino acid receptors by neuroactive steroids: Physiological and pharmacological Implications, <i>T.T. Gibbs and</i> <i>D. Farb</i> <br>On the neurosteroid mechanisms of action and their clinical potentials, <i>Y. Akwa and E. Baulieu</i>
Summary A complete overview of the effects of steroid hormones in the brain and describes new methods for investigating these effects. The author discusses the latest theories on steroid action in the central nervous system and the techniques for receptor localization and quantification and enzyme regulation. He also explores the use of transgenic/antisense strategies to determine sites and the cellular effects of steroid action in the brain. The material covers the range of steroid action on such end points as mood, cognition, sensorimotor action, neuroprotection, and plasticity, and it describes methods using molecular, electrophysical, and behavioral techniques to link cellular mechanisms of steroid action with behavioral effects
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Neurohormones -- Physiological effect
Steroids -- Physiological effect
GABA -- Receptors.
Neurotransmitter receptors.
Receptors, GABA-A -- physiology
Receptors, Neurotransmitter
Central Nervous System -- physiology
MEDICAL -- Neuroscience.
PSYCHOLOGY -- Neuropsychology.
GABA -- Receptors
Neurotransmitter receptors
Steroids -- Physiological effect
Form Electronic book
Author Smith, Sheryl S
ISBN 0203508165