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Title Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition / editors, Robert A. Bonomo, Marcelo Tolmasky
Published Washington, D.C. : ASM Press, ©2007


Description 1 online resource (xviii, 357 pages, 8 unnumbered pages of plates) : illustrations (some color)
Contents Overview of aminoglycosides and enzyme-mediated bacterial resistance: clinical implications / Robert A. Bonomo -- Aminoglycoside antibiotics / Kanchana Majumder [and others] -- Structural aspects of aminoglycoside-modifying enzymes / Gerard D. Wright and Albert M. Berghuis -- Aminoglycoside-modifying enzymes: characteristics, localization, and dissemination / Marcelo E. Tolmasky -- rRNA methylases and resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone (MLSKO) antibiotics / Marilyn C. Roberts -- [Beta]-lactamases: historical perspectives / Karen Bush and Patricia A. Bradford -- Resistance mediated by penicillin-binding proteins / Malcolm G.P. Page -- Inhibition of class A [beta]-lactamases / Samy O. Meroueh, Jooyoung Cha, And Shahriar Mobashery -- Class B [beta]-lactamases / Gian Maria Rossolini and Jean-Denis Docquier -- Crystal structures of class C [beta]-lactamases: mechanistic implications and perspectives in drug design / C. Bauvois and J. Wouters
Class D [beta]-lactamases / Franck Danel, Malcolm G.P. Page, and David M. Livermore -- Kinetics of [beta]-lactamases and penicillin-binding proteins / Moreno Galleni and Jean-Marie Frère -- The pharmaceutical industry and inhibitors of bacterial enzymes: implications for drug development / David M. Shlaes, Lefa Alksne, and Steven J. Projan -- [Beta]-lactamase inhibitory proteins / Zhen Zhang and Timothy Palzkill -- Active drug efflux in bacteria / Jürg Dreier -- Overview of dissemination mechanisms of genes coding for resistance to antibiotics / Marcelo E. Tolmasky -- Conjugative transposons / Louis B. Rice -- The dissemination of antibiotic resistance by bacterial conjugation / Virginia L. Waters -- Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics / Juan C. Alonso [and others] -- Integrons and superintegrons / Robert A. Bonomo, Andrea M. Hujer, and Kristine M. Hujer -- The biological cost of antibiotic resistance / Dan I. Andersson [and others]
Summary Antibiotic-resistant bacteria, or "superbugs," present an increasingly deadly threat to human health. With chapters from the world's leading researchers and scholars in this field, this comprehensive volume is a vital and timely overview of this critical subject
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Drug resistance in microorganisms.
Drug resistance in microorganisms -- Genetic aspects.
Microbial enzymes.
Enzyme inhibitors.
Anti-Bacterial Agents
Drug Resistance, Bacterial
Enzyme Inhibitors
beta-Lactamase Inhibitors
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Enzyme inhibitors.
Drug resistance in microorganisms.
Drug resistance in microorganisms -- Genetic aspects.
Microbial enzymes.
Form Electronic book
Author Bonomo, Robert A., editor
Tolmasky, Marcelo, editor
LC no. 2007002039
ISBN 9781555815615