CD40 and CD154 / Iqbal S. Grewal -- Regulation of T cell immunity by OX40 and OX40l / Michael Croft [and others] -- Signal transduction in osteoclast biology: the OPG-RANKL-RANK pathway / Ji Li -- Tumor necrosis factor (TNF) and neurodegeneration / Rammohan V. Rao and Dale E. Bredesen -- The role of light in autoimmunity / Jing Wang and Yang-Xin Fu -- CD137 pathway in innate and adaptive immunity / Ryan A. Wilcox and Lieping Chen
Summary
The tumor necrosis factor/receptor [TNF/TNFR] superfamily consists of more than 20 transmembrane proteins with conserved N-terminal cysteine-rich domains [CRDs] in the extracellular ligand binding region. Members have wide tissue distribution and play important roles in biological processes such as lymphoid and neuronal development, innate and adaptive immune response, and cellular homeostasis. The chapters of this book address some of the most interesting functions of the TNF/TNFR superfamily
