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Book Cover

Title Leptin and leptin antagonists / [edited by] Arieh Gertler
Published Austin, Tex. : Landes Bioscience, ©2009


Description 1 online resource (165 pages) : illustrations
Series Medical intelligence unit
Medical intelligence unit (Unnumbered : 2003)
Contents Leptin signal transduction : a 2009 update / Walter Becker -- Insights in the activated LR complex and the rational design of antagonists / Frank Peelman, Lennart Zabeau, Jan Tavernier -- Study of leptin : leptin receptor interaction by FRET and BRET / Julie Dam [and others] -- Is leptin a pro- or anti-apoptotic agent? / Srujana Rayalam [and others] -- Leptin actions in the gastrointestinal tract / Sandra Guilmeau [and others] -- Leptin as a novel marker in breast and colorectal cancer / Eva Surmacz and Mariusz Koda -- The role of leptin in cardiac physiology and pathophysiology / Morris Karmazyn [and others] -- The role of leptin in bone development and growth / Efrat Monsonego Ornan and Michal Ben-Ami -- Involvement of leptin in arterial hypertension / Jerzy Beltowski -- Involvement of leptin in the endometrial function / Ana Cervero and Carlos Simon -- The use of leptin for the treatment of lipodystrophy / Angeline Y. Chong, Elaine K. Cochran, Phillip Gorden -- Use of anti-leptin or anti-leptin receptor antibodies as blockers of immune response / Giuseppe Matarese and Veronica De Rosa -- Use of leptin antagonists as anti-inflammatory and anti-fibrotic reagents / Eran Elinav and Arieh Gertler -- The role of leptin during early life in imprinting later metabolic responses / Mark H. Vickers [and others]
Summary The discovery of leptin, the obese (ob) gene product which is not expressed as a functional protein in ob/ob mice, focused the scientific community's attention on its role as an anorexic hormone involved in the negative regulation of food intake. Almost 14 years after this breakthrough discovery and over 14,000 leptin-related publications later, leptin is now known to participate in a wide range of biological functions that include, in addition to its early envisaged function as an adipostat, glucose metabolism, glucocorticoid synthesis, CD4+ T-lymphocyte proliferation, cytokine secretio
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Leptin.
Leptin -- Inhibitors
Leptin -- antagonists & inhibitors
Receptors, Leptin
SCIENCE -- Life Sciences -- Biochemistry.
Form Electronic book
Author Gertler, Arieh.
ISBN 9781441604514