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Title Astrocytes : wiring the brain / edited by Eliana Scemes, David C. Spray
Published Boca Raton : CRC Press, ©2012


Description 1 online resource
Series Frontiers in neuroscience
Frontiers in neuroscience (Boca Raton, Fla.)
Contents Section 1. Introduction to cluster A : functional biomarkers at the interface -- section 2. Introduction to cluster B : establishment of functional units : multimodality at the tips -- section 3. CNS pathology : disruption of astrocyte connectivity : introduction
Summary "Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain emphasizes cellular connections and surveys the most current findings on astrocyte activity. The first section of the book identifies major astrocyte biomarkers and describes how they define the different connectivity domains. Next, the book examines the role of these connections. It explains how their function can be manipulated under physiological conditions and how dysfunction of the connectivity leads to aberrant brain performance. The final section explores the alterations of glia that have been observed in specific diseases of the brain. These include epilepsy, autoimmune encephalitis, Alzheimers disease, autism, and major depression. The book identifies key mechanisms responsible for these alterations. An important and emerging field, astrocytes and their functions are critical to neuroscientists and neurologists, both in academia and in industry, particularly in the search for and development of new drugs to combat a variety of diseases affecting the CNS. As research continues to grow in this area, this volume will spur heightened advances and understanding into the effects of these neural cells on a range of pathologies"--Provided by publisher
Bibliography Includes bibliographical references and index
Subject Astrocytes.
Nervous system -- Cytopathology
Astrocytes -- physiology
Central Nervous System -- physiology
Central Nervous System Diseases -- physiopathology
Mental Disorders -- physiopathology
Form Electronic book
Author Scemes, Eliana
Spray, David C
ISBN 9781439825846