| Description |
1 online resource (ix, 562 pages) : illustrations |
| Series |
Advances in experimental medicine and biology ; volume 1389 |
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Advances in experimental medicine and biology ; v. 1389.
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| Contents |
Intro -- Preface -- Contents -- About the Editors -- 1: Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges -- 1.1 Discovery of DNA Methylation -- 1.2 Discovery and Early Work on DNA MTases -- 1.3 DNA MTases Contain Conserved Amino Acids Sequence Motifs -- 1.4 Structure and Mechanism of DNA MTases -- 1.5 Molecular Evolution of MTases -- 1.6 Early Views on the Biological Role of DNA Methylation -- 1.7 Genetic Studies on DNMTs in Mammals -- 1.8 Structure, Function, and Regulation of Mammalian DNA MTases |
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1.9 Discovery of TET Enzymes -- 1.10 Methods for Site-Specific Detection of DNA Methylation -- 1.11 DNA MTases and Bacterial Epigenetics -- 1.12 Role of DNA Methylation in Cancer -- 1.13 Application of MTases in Artificial Epigenetic Systems -- 1.14 Conclusions and Outlook -- References -- 2: DNA Methylation in Prokaryotes -- 2.1 Introduction -- 2.2 CcrM Methylation -- 2.3 Dam Methylation -- 2.3.1 Role of Dam Methylation in DNA Mismatch Repair -- 2.3.2 Control of Chromosome Replication by Dam Methylation -- 2.3.3 Transcriptional Control by Dam Methylation |
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2.3.3.1 Temporal Regulation of Gene Expression by Dam Methylation -- 2.3.3.2 Regulation of Bistability by Dam Methylation -- 2.4 Phase Variable DNA Adenine Methylation -- 2.5 Additional Examples of DNA Adenine Methylation -- 2.6 C5-Methylcytosine -- 2.7 N4-Methylcytosine -- 2.8 Biomedical and Biotechnological Applications of Dam Methylation -- References -- 3: Domain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases -- 3.1 DNA Methylation and Methyltransferases in Mammals -- 3.2 Enzymes Responsible for the Establishment of DNA Methylation Patterns -- 3.2.1 PWWP Domain |
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3.2.2 ADD Domain -- 3.2.3 Catalytic Domain -- 3.2.4 Functions of Other Regions -- 3.2.5 Factors That Guide Dnmt3 to the Regions to Be Methylated -- 3.2.6 Correlation Between de novo DNA Methylation and Histone Modifications -- 3.3 Enzymes Responsible for the Maintenance of DNA Methylation Patterns -- 3.3.1 NTD -- 3.3.2 RFTS Domain -- 3.3.3 CXXC -- 3.3.4 Two BAH Domains -- 3.3.5 Catalytic Domain -- 3.4 Cross-Talk Between De Novo-Type and Maintenance-Type DNA Methyltransferases -- 3.5 Conclusions and Perspective -- References -- 4: Enzymology of Mammalian DNA Methyltransferases -- 4.1 Introduction |
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4.2 General Features of Mammalian DNMTs -- 4.2.1 Structure and Domain Composition of Mammalian DNMTs -- 4.2.2 Catalytic Mechanism of C5-MTases -- 4.2.3 Regulation and Targeting of DNMTs -- 4.3 Structure, Function, and Mechanism of DNMT1 -- 4.3.1 Domain Composition of DNMT1 -- 4.3.2 Structures of DNMT1 and Allosteric Regulation -- 4.3.3 Specificity of DNMT1 -- 4.3.4 Processivity of DNMT1 -- 4.3.5 Allosteric Regulation and Targeting of DNMT1 -- 4.3.5.1 The DNMT1-PCNA Interaction -- 4.3.5.2 The DNMT1-UHRF1 Interaction -- 4.3.5.3 Binding of the DNMT1-RFTD to Ubiquitinated H3 Tails |
| Summary |
This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. As the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 16, 2022) |
| Subject |
DNA.
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Methyltransferases.
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DNA
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Methyltransferases
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Metilació.
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ADN.
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| Genre/Form |
Llibres electrònics.
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| Form |
Electronic book
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| Author |
Jeltsch, Albert, editor.
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Jurkowska, Renata Z., editor.
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| ISBN |
9783031114540 |
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303111454X |
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