Title Amyotrophic lateral sclerosis / edited by Hiroshi Mitsumoto, Serge Przedborski, Paul H. Gordon

Published Boca Raton : Taylor & Francis, 2006

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Description 1 online resource (xxvi, 830 pages) : illustrations (some color) Series Neurological disease and therapy ; 78 Neurological disease and therapy ; 78. Contents History of ALS -- Epidemiology of ALS -- The pathology of amyotrophic lateral sclerosis -- The causes of sporadic amyotrophic lateral sclerosis -- ALS clinical motor signs and symptoms -- Frontotemporal dysfunction in amyotrophic lateral sclerosis -- Familial ALS and genetic approaches to ALS -- Objective markers of upper and lower motor neuron dysfunction: electrophysiological studies and neuroimaging technologies -- Classification, diagnosis, and presentation of diagnosis of ALS -- Natural history and prognosis in amyotrophic lateral sclerosis -- Specifying motor identity in the developing spinal cord -- Neurodegeneration in amyotrophic lateral sclerosis -- Excitotoxicity -- Superoxide dismutase, oxidative stress, and ALS -- Neuronal and non-neuronal cell interactions in ALS -- Apoptosis in amyotrophic lateral sclerosis -- Cytoskeletal proteins in the pathogenesis of ALS -- Role of mitochondria in motor neuron degeneration in ALS -- Environmental toxicity and ALS: novel insights from an animal model of ALS-PDC -- Genetic causes and predisposition -- ALS: a protein aggregate disease? -- Neuroinflammation -- The potential of gene therapy for motor neuron diseases -- Experimental models of motor neuron diseases -- Screening for ALS drugs -- Clinical trial methodology -- The multidisciplinary care clinic: the principles and an international perspective -- The ALS patient CARE program -- North American patient CARE database -- Symptomatic pharmacotherapy: bulbar and constitutional symptoms -- ALS pharmacotherapy: riluzole and clinical trials -- Rehabilitation -- Nutritional treatment: theoretical and practical issues -- Respiratory care in amyotrophic lateral sclerosis -- Psychosocial care for patients with ALS and their caregivers -- Palliative care at the end of life -- Palliative care: family perspective -- End-of-life decision making Summary With cutting-edge contributions from internationally recognized experts and field pioneers, Amyotrophic Lateral Sclerosis is the definitive guide to the subject. Formatted in an easily accessible manner, with summaries of key points at the end of each chapter, this guide covers all the essential information clinicians require for daily practice, as well as providing a reader-friendly approach to every aspect of ALS with detailed sections on the clinical features of disease, translational research, patient care and management, and emerging therapies Bibliography Includes bibliographical references and index Notes Print version record Subject Amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis HEALTH & FITNESS -- Diseases -- Alzheimer's & Dementia. MEDICAL -- Neurology. Amyotrophic lateral sclerosis Form Electronic book Author Mitsumoto, Hiroshi Przedborski, Serge Gordon, Paul H LC no. 2005053812 ISBN 1420027441 9781420027440

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