| Description |
1 online resource (221 pages) |
| Series |
Series in Medical Physics and Biomedical Engineering Ser |
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Series in Medical Physics and Biomedical Engineering Ser
|
| Contents |
Cover; Half Title; Title Page; Copyright Page; Table of Contents; Foreword; Preface; Series Preface; About the Series; The International Organization for Medical Physics; Authors; Chapter 1: Introductory Aspects of Head and Neck Cancers; 1.1 Historic Aspects; 1.2 Head and Neck Cancer Anatomy; 1.3 Anatomic Landmarks of Some Sites and Subsites Commonly Affected By Malignant Head and Neck Tumours; 1.4. Incidence of Head and Neck Cancer; 1.5 Risk Factors and Pathogenesis of Head and Neck Cancer; 1.5.1 Tobacco and Alcohol Consumption; 1.5.2 The Human Papillomavirus; 1.5.3 Other Risk Factors |
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1.6 Pathology and PathogenesisChapter 2: Clinical Aspects of Head and Neck Cancer; 2.1 Introduction; 2.2 Short Historical Perspective of Head and Neck Cancer Treatment; 2.3 Overview of Tumour Site-Related Treatment Techniques for the Management of Head and Neck Cancer; 2.3.1 Oral Cancers; 2.3.2 Salivary Gland Cancer; 2.3.3 Cancer of Nasal Cavity and Paranasal Sinuses; 2.3.4 Nasopharyngeal Carcinoma; 2.3.5 Oropharyngeal Carcinoma; 2.3.6 Hypopharyngeal Carcinoma; 2.3.7 Laryngeal Carcinoma; 2.4 Chemoradiotherapy In Head and Neck Cancer from the Early Days to the Present |
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2.5 Hopes and Failures in Head and Neck Cancer Radiobiology and Therapy2.5.1 Tumour Repopulation and Altered Fractionation Schedules; 2.5.1.1 The Future of Fractionated Radiotherapy; 2.5.2 Therapeutic Ratio and Cisplatin; 2.5.2.1 The Future of Cisplatin; 2.5.3 Tumour Hypoxia and Tirapazamine; 2.5.3.1 The Future of Tirapazamine; 2.5.4 Epidermal Growth Factor Receptor and Cetuximab; 2.5.4.1 The Future of Cetuximab; 2.5.5 Vascular Endothelial Growth Factor and Bevacizumab; 2.5.5.1 The Future of Bevacizumab; 2.5.6 Normal Tissue Protection and Amifostine/Radioprotectors |
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2.5.6.1 The Future of Radioprotectors2.5.7 HPV-Associated Head and Neck Cancer; 2.5.7.1 The Future of HPV-Associated HNC Treatment; Chapter 3: General Radiobiology Refresher; 3.1 Radiation Quantities and Units; 3.2 Radiation Action and Radiation Damage; 3.3 Dose Rate Effect, LET and RBE; 3.4 The Oxygen Effect; 3.5 Proliferation Kinetics and Parameters; 3.6 Dose-Response Relationships; Chapter 4: Hypoxia and Angiogenesis; 4.1 Tumour Hypoxia; 4.2. Methods to Identify Tumour Hypoxia in HNC; 4.3 Methods to Overcome Tumour Hypoxia; 4.4 Angiogenesis and VEGF |
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Chapter 5: The Mechanisms Behind Tumour Repopulation5.1 Introduction; 5.2 Cancer Stem Cells; 5.2.1 The Concept of Cancer Stem Cell; 5.2.2 Cancer Stem Cells in HNC; 5.3 The Mechanisms Behind Tumour Repopulation; 5.3.1 Cell Recruitment; 5.3.2 Accelerated Stem Cell Division; 5.3.3 Loss of Asymmetrical Division of Cancer Stem Cells; 5.4 Clinical Implications; 5.4.1 Predictive Assays and Detection Methods; 5.4.2 Altered Fractionation Schedules; 5.5 Cancer Stem Cell-Targeting Mechanisms; 5.5.1 Signalling Pathways; 5.5.2 The Stem Cell Niche; 5.5.3 Cancer Stem Cell Differentiating Agents |
| Notes |
5.5.4 Other CSC Targets |
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Print version record |
| Subject |
Head-Cancer-Radiotherapy
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Neck-Cancer-Radiotherapy
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Head -- Cancer -- Radiotherapy
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Neck -- Cancer -- Radiotherapy
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Head -- Cancer -- Radiotherapy
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Neck -- Cancer -- Radiotherapy
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| Form |
Electronic book
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| Author |
Toma-Dasu, Iuliana
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Dasu, Alexandru
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Mercke, Claes
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| ISBN |
9781351001991 |
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135100199X |
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