| Description |
1 online resource (404 p.) |
| Contents |
Front Cover -- Clinical Aspects of Multiple Sclerosis Essentials and Current Updates -- Clinical Aspects of Multiple Sclerosis Essentials and Current Updates -- Copyright -- Contents -- Contributors -- Preface -- Acknowledgment -- 1 -- Introduction to multiple sclerosis: Subtypes, pathogenesis, and diagnostic criteria -- Introduction -- Multiple sclerosis: knowledge and inference -- Multiple sclerosis: epidemiology -- Multiple sclerosis: pathogenesis -- Multiple sclerosis: histological classification -- Multiple sclerosis: clinical classification -- Multiple sclerosis: diagnostic criteria |
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Multiple sclerosis: new formalized terms-CIS and RIS -- Clinically isolated syndrome -- Radiologically isolated syndrome -- Case example -- Multiple sclerosis: history and future prospects -- Conflict of interest statement -- References -- 2 -- An overview of neuromyelitis optica spectrum disorders -- Overview and epidemiology -- Pathophysiology -- Clinical presentation -- Histopathological findings -- Radiological findings -- Diagnosis -- Management -- Treatment of acute attacks -- Preventative (maintenance) therapy -- Off-label disease-modifying therapies -- Rituximab -- Azathioprine |
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Mycophenolate mofetil -- Methotrexate -- FDA-approved therapies -- Targeting the complement system (eculizumab, soliris) -- Targeting B-lymphocytes cells: (inebilizumab) -- Targeting the IL-6 receptor (satralizumab, enspryng) -- Emerging therapies and ongoing trials -- Tocilizumab -- Aquaporumab (rAb-53) -- Bevacizumab -- Ublituximab -- Autologous hematological stem cell transplantation -- Conflict of interest statement -- References -- 3 -- Epidemiology, epigenetics, and etiological factors in multiple sclerosis -- Prevalence and geography -- Demographics -- Genetics |
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Genome wide association studies -- Interleukin 7 receptor alpha, interleukin 2 receptor alpha -- Human leukocyte antigen genes -- Epigenetics -- Environmental risk factors -- Epstein-Barr virus -- Human endogenous retrovirus type W -- Cytomegalovirus -- Human herpesvirus 6 -- UVB and latitude -- Vitamin D -- Smoking -- Obesity -- Dietary salt intake -- Microbiome -- Conflict of interest statement -- References -- 4 -- Beyond MS: Other demyelinating disorders and common mimickers -- Introduction -- Neuromyelitis optica spectrum disorder |
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Myelin oligodendrocyte glycoprotein antibody-associated disease -- Sarcoidosis -- Systemic lupus erythematosus -- Sjögren's syndrome -- Vitamin B12 deficiency -- Adult-onset leukodystrophies -- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy -- Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids -- Behçet's disease -- Susac syndrome -- Leber hereditary optic neuropathy -- CNS vasculitis -- References -- 5 -- Disease-modifying therapies: Current landscape and emerging approaches -- Treatment strategies |
| Notes |
Description based upon print version of record |
|
Disease-modifying therapies |
| Form |
Electronic book
|
| Author |
Bernitsas, Evanthia
|
| ISBN |
9780323953429 |
|
0323953425 |
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