| Description |
1 online resource (xi, 663 pages) : illustrations |
| Series |
Results and problems in cell differentiation ; volume 70 |
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Results and problems in cell differentiation ; 70
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| Contents |
Intro -- Preface -- Book Abstract -- Contents -- Part I: Genome Architecture, Evolution, and Cell Fate -- Chapter 1: Networks and Islands of Genome Nano-architecture and Their Potential Relevance for Radiation Biology -- 1.1 Introduction to Radiation-Induced DNA Damage and Repair -- 1.2 Methods of Nanoscale Microscopic Analysis of the Cell Nucleus as a System at a Whole: Single-Molecule Localization Microsc... -- 1.3 The Cell Nucleus: A Complex System as a Whole -- 1.4 Radiation-Induced Chromatin Damage: A Complex System as a Whole Under Environmental Stress |
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1.5 Experimental Hints for System Response as a Whole After Radiation-Induced DNA Damaging -- 1.6 Experimental Hints for Similarity of Local System Response (Islands) After Radiation-Induced DNA Damaging -- 1.7 Conclusion -- References -- Chapter 2: A Unified Genomic Mechanism of Cell-Fate Change -- 2.1 Introduction: Self-Organization of Genome Expression -- 2.2 Classical Self-Organized Criticality Models -- 2.2.1 c-SOC Model -- 2.2.2 Rapid SOC Model -- 2.3 SOC Control of Genome Expression Regulation -- 2.4 Genome Engine: Open Thermodynamic View of Genome Expression System |
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2.5 Self-Organization of Whole Gene Expression Through Coordinated Chromatin Structural Transition -- 2.6 Synchronization Between Critical Point and Genome Attractor: CP as the Organizing Center of Cell-Fate Change -- 2.6.1 Critical Transition Transmitted to the Genome -- 2.7 Discussion -- 2.7.1 Different Biological Systems -- 2.7.1.1 MCF-7 Breast Cancer Cells: Global and Local Perturbations -- 2.7.1.2 HL-60 Human Leukemia Cells: Commitment to Differentiation -- 2.7.1.3 Human and Mouse Embryos: Developmental Oocyte-to-Embryo Transition |
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2.7.2 Genome Computing: CP Acting as the Center of Genome Computing -- 2.8 Conclusion: A Unified Genomic Mechanism -- 2.9 Methods -- 2.9.1 Biological Data Sets -- 2.9.2 Normalized Root Mean Square Fluctuation (nrmsf) -- 2.9.3 Updated Expression Flux Analysis -- References -- Chapter 3: Alterations to Genome Organisation in Stem Cells, Their Differentiation and Associated Diseases -- 3.1 Introduction -- 3.2 Different Types of Stem Cells -- 3.3 Nuclear Structures -- 3.3.1 The Nuclear Lamina -- 3.3.2 Nucleoli and Nuclear Bodies -- 3.4 Interphase Genome Organisation -- 3.5 Cellular Senescence |
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3.6 Alterations to Nuclear Organisation Leading to Plasticity in Differentiated Cells -- 3.7 Genome Behaviour in Laminopathies, Including Hutchinson-Gilford Progeria Syndrome -- 3.8 Chromosomal Translocations, Genome Reorganisation and Disease -- 3.9 Genome Behaviour in Colorectal Cancer, a Solid Tumour -- 3.9.1 GREM1 Duplication -- 3.10 Summary -- References -- Chapter 4: How Genomes Emerge, Function, and Evolve: Living Systems Emergence-Genotype-Phenotype-Multilism-Genome/Systems Ecol... -- 4.1 Introduction -- 4.2 A Short History of 3D Genome Organization and Its Finalization |
| Summary |
This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed November 16, 2022) |
| Subject |
Cytology.
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Chromosomes.
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Genomics.
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Cell nuclei.
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Cell differentiation.
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Cell differentiation
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Cell nuclei
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Chromosomes
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Cytology
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Genomics
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| Form |
Electronic book
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| Author |
Kloc, Malgorzata, editor
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Kubiak, Jacek Z., editor
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| ISBN |
9783031065736 |
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3031065735 |
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