Description |
1 online resource (xv, 151 pages) : illustrations (some color) |
Series |
Advances in experimental medicine and biology ; v. 676 |
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Advances in experimental medicine and biology ; v. 676.
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Contents |
Polyploidy, aneuploidy and the evolution of cancer / Lauren M.F. Merlo [and others] -- Molecular mechanisms and function of the spindle checkpoint, a guardian of the chromosome stability / Daisuke Ito and Tomohiro Matsumoto -- Understanding cytokinesis failure / Guillaume Normand and Randall W. King -- DNA damage and polyploidization / Jeremy P.H. Chow and Randy Y.C. Poon -- Role of the p53 family in stabilizing the genome and preventing polyploidization / Flaminia Talos and Ute M. Moll -- Centrosomes, polyploidy and cancer / Anette Duensing and Stefan Duensing -- Polyploidy : mechanisms and cancer promotion in hematopoietic and other cells / Hao G. Nguyen and Katya Ravid -- Polyploidization of liver cells / Séverine Celton-Morizur and Chantal Desdouets -- Analysis of cellular DNA content by flow and laser scanning cytometry / Zbigniew Darzynkiewicz, H. Dorota Halicka and Hong Zhao |
Summary |
Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relati |
Bibliography |
Includes bibliographical references and index |
Notes |
Print version record |
In |
Springer eBooks |
Subject |
Cancer -- Genetic aspects.
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Polyploidy.
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Neoplasms -- genetics
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Chromosomal Instability -- genetics
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Gene Expression Regulation, Neoplastic -- genetics
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Polyploidy
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HEALTH & FITNESS -- Diseases -- Cancer.
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MEDICAL -- Oncology.
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Biomédecine.
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Sciences de la vie.
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Cancer -- Genetic aspects
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Polyploidy
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Form |
Electronic book
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Author |
Poon, Randy Y. C
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ISBN |
9781441961990 |
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1441961992 |
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1283074419 |
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9781283074414 |
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