| Description |
1 online resource (xii, 501 pages) : illustrations (some color) |
| Series |
Advances in neurobiology ; volume 29 |
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Advances in neurobiology ; 29.
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| Contents |
Intro -- Preface -- Postscript: In Memoriam -- Contents -- Chapter 1: Introduction to the Complexity of Cell Surface and Tissue Matrix Glycoconjugates -- 1 Introduction -- 2 Monosaccharides: Building Blocks of Glycans -- 3 Formation of Oligosaccharides -- 4 Classification of Glycans -- 5 Structural Features of N-Glycans -- 6 Structural Features of O-Glycans -- 7 Biosynthesis of N- and O-Glycans -- 8 Glycosphingolipids -- 9 Structural Features of the Glycan Moieties of Glycosphingolipids -- 10 Synthesis and Functions of the Glycan Moieties of Glycolipids |
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11 Glycosylphosphatidylinositol Anchors: A Special Group of Glycolipids -- 12 Glycosaminoglycans and Proteoglycans -- 13 Glycan-Protein Interactions -- 14 Glycans of Cell Surface Glycoconjugates Perform a Variety of Functions -- 15 Summary -- References -- Chapter 2: Cells of the Central Nervous System: An Overview of Their Structure and Function -- 1 Introduction -- 2 Neurons -- 2.1 Neuronal Cell Body -- 2.2 Cytoskeleton -- 2.3 Dendrites -- 2.4 Axon -- 2.5 Synapse -- 3 Supporting Cells -- 3.1 Astrocytes -- 3.2 Oligodendrocytes -- 3.3 Microglia -- 3.4 NG2 Cells (Polydendrocytes) |
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3.5 Ependymal Cells -- 4 Extracellular Matrix -- 5 Concluding Remarks -- References -- Chapter 3: Synthesis, Processing, and Function of N-Glycans in N-Glycoproteins -- 1 Introduction -- 2 N-glycans Are First Born on a Lipid and Then Transferred "En Bloc" onto the Nascent N-glycoprotein in the ER -- 3 Trimming, Reglycosylation, and Remodeling: There Are Many Ways of N-glycoprotein Processing in the ER and Golgi -- 4 The Essential Toolbox of a Glycobiologist: A Brief History of the Discovery of N-glycoprotein Biosynthesis Inhibitors and Their Impact on Our Understanding of N-glycan Processing |
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5 Sweetening the Bond or Sugar-Coating Bad News: Recent Advances in the Role of N-glycans for Virus Infections and Immune Responses -- 6 Sweet Encounters of Glycoproteins and Glycolipids: N-glycans Affect the Subcellular Distribution and Complex Formation of Enzymes in Glycolipid Biosynthesis -- 7 Conclusions and Epilogue: The Tale of the Tail That Wags the Dog -- References -- Chapter 4: Synthesis of O-Linked Glycoconjugates in the Nervous System -- 1 Introduction -- 2 Biosynthesis of O-Linked Proteins -- 2.1 O-GalNAcylation -- 2.2 O-Mannosylation -- 2.3 O-GlcNAcylation -- 2.4 O-Xylosylation |
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2.5 O-Fucosylation -- 2.6 O-Glucosylation -- 3 Biosynthesis of O-Linked Lipids -- 3.1 Glucosylceramide and Glycosphingolipids -- 3.2 Galactosylceramide and Glycosphingolipids -- 3.3 GlcCer and GM3 Synthase Deficiency in Human and Mouse -- 3.4 Other O-Linked Lipids - New Glucose-Related Lipids -- 4 Conclusions -- References -- Chapter 5: Chemistry and Function of Glycosaminoglycans in the Nervous System -- 1 Introduction -- 2 Glycosaminoglycan Structure and Chemistry -- 2.1 Chondroitin Sulfate (CS) -- 2.1.1 Structure and Chemistry -- 2.1.2 Synthesis and Modification of CS Chains |
| Summary |
This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Previous edition: 2014 |
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Online resource; title from PDF title page (SpringerLink, viewed October 31, 2022) |
| Subject |
Glycomics.
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Nervous system -- Microbiology
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Glycoconjugates.
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Neurobiology.
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Glycoconjugates
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Glycomics
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Neurobiology
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| Form |
Electronic book
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| Author |
Yu, Robert K., editor.
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Schengrund, Cara-Lynne, editor.
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| ISBN |
9783031123900 |
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3031123905 |
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