| Description |
1 online resource (439 p.) |
| Contents |
Front Cover -- Viruses -- Copyright Page -- Contents -- About the author -- Preface -- Acknowledgments -- 1 Introduction to animal viruses -- What is a virus? -- Diversity in the world of viruses -- Are viruses alive? -- Basic steps in the virus replication-cycle -- Propagating viruses -- Categorizing viruses (taxonomy) -- Outcomes of viral infection -- Introduction to viral pathogenesis -- Introduction to viral transmission -- References -- 2 Virus structure -- Anatomy of a virus -- Capsid structure and function -- Capsids are built using many copies of one or a few types of protein |
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Simple icosahedral capsids -- Larger icosahedral capsids -- Polyomavirus and papillomavirus capsids -- Adenovirus capsids -- Reoviruses -- Herpesvirus capsids -- Surface structures of capsids -- Viral envelopes -- Glycosylation -- Other membrane proteins -- Matrix proteins -- Nucleocapsid structure -- References -- 3 Virus interactions with the cell -- Virion attachment -- The extracellular space -- The plasma membrane -- Attachment -- Virus penetration and uncoating -- Virus penetration and uncoating of unenveloped viruses -- Virus penetration and uncoating of enveloped viruses |
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Movement through the cell, interactions with the cytoskeleton -- Amplification of viral proteins and nucleic acids in the context of the infected cell -- A short review of transcription in the eukaryotic cell -- Transcription of viral mRNAs -- A short review of translation in the eukaryotic host cell -- Translation of viral proteins -- Synthesis of viral genomes -- The endgame: virus assembly, release, and maturation -- Assembly -- Virion release -- Virion maturation -- 4 Methods to study viruses -- Growing viruses -- Generating cell cultures -- Purifying viruses -- Visualizing viruses |
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Optical microscopy -- Electron microscopy -- Counting viruses -- Infectivity assays -- Chemical/physical methods of virus quantitation -- Direct visualization by electron microscopy -- Hemagglutination assay -- Serological assays -- Enzyme-linked immunosorbent assays -- Western blots -- Genome detection and quantitation by PCR -- Basic principles of diagnostic virology -- Deep sequencing for virus discovery and characterization -- References -- 5 Virus transmission and epidemiology -- Modes of transmission -- Respiratory routes -- Food and water -- Exchange of body fluids -- Insect vectors |
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Role of the host specificity in virus transmission -- Transmissibility -- Describing viral infection and disease -- Infection versus disease -- Pathogenicity and virulence -- Acute versus persistent infection -- Incubation, latent, and infectious periods -- Incidence versus prevalence -- 6 Immunity and resistance to viruses -- What is immunity? -- Innate immunity -- Pattern recognition receptors -- Toll-like receptors -- Retinoic acid-inducible gene-like receptors -- Nucleotide-binding oligomerization domain (NOD)-like receptors -- Pyrin and HIN200 domain-containing proteins |
| Notes |
Description based upon print version of record |
|
Cyclic GMP-AMP synthase |
| Form |
Electronic book
|
| ISBN |
9780323984768 |
|
0323984762 |
|
