| Description |
1 online resource (255 pages) |
| Contents |
Preface; Acknowledgements; 1 Scope of Toxicology ; 1.1 Toxicology and Mechanisms of Toxicity ; 1.2 Definition of Toxicology and Toxicity ; 1.2.1 Organisms ; 1.2.2 Responses ; 1.2.3 Toxic Chemicals ; 1.3 Origin and Types of Exposure ; 1.3.1 Medical and Veterinary Practice ; 1.3.2 Exposure at Work ; 1.3.3 Environmental Exposure ; 1.3.4 Accidental and Intentional Exposure ; 1.4 Discussion ; 1.5 Summary ; 2 Stages in the Induction of Toxicity ; 2.1 Introduction ; 2.2 Five Stages in Toxicity ; 2.3 Exposure and Entry of Chemicals ; 2.4 Delivery of Intoxicant |
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2.5 Interactions with Targets 2.6 Early Changes and Clinical Consequences ; 2.7 Discussion ; 2.8 Summary ; 3 Kinetics and End-points ; 3.1 Introduction ; 3.2 Reversible Interactions ; 3.3 Covalent Interactions ; 3.4 Michaelis Constants ; 3.5 Criteria to Distinguish Reversible from Covalent Interactions ; 3.6 In vivo Kinetics ; 3.7 Discussion ; 3.8 Summary ; 4 Acute and Chronic Intoxication ; 4.1 Introduction ; 4.2 Single Exposure, Rapid Biological Effect, Rapid Recovery ; 4.3 Continuous Exposure, Rapid Biological Effect, Slow but Complete Recovery |
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4.4 Single Exposure, Rapid Biological Effect, Slow but Complete Recovery 4.5 Single Exposure, Latent Intoxication, Little or No Recovery ; 4.6 Single or Repeated Exposures, Rapid Intoxication, Irreversible Secondary Changes ; 4.7 Single Exposure, Latent Intoxication, No Recovery ; 4.8 Discussion ; 4.9 Summary ; 5 Delivery of Intoxicant ; 5.1 Introduction ; 5.1.1 DDT ; 5.1.2 Methyl Isocyanate ; 5.2 Delivery (Entry and Distribution) ; 5.3 Movement across Membranes ; 5.3.1 Passive Diffusion ; 5.3.2 Filtration ; 5.3.3 Facilitated Diffusion and Active Transport |
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5.3.4 Endocytosis: Pinocytosis and Phagocytosis 5.3.5 Absorption from the Castro-intestinal Tract ; 5.4 Distribution ; 5.5 Factors which Reduce the Concentration of Free Intoxicant ; 5.5.1 Albumin ; 5.5.2 Haemoglobin ; 5.5.3 Ligandin (Glutathione S-transferase) ; 5.5.4 Metallothionein ; 5.5.5 Adipose Tissue ; 5.5.6 Excretion ; 5.5.7 The Enzymes and Chemistry of Detoxification ; 5.5.8 The Detoxification of Electrophiles, Oxidants and Active Oxygen Metabolites ; 5.6 Discussion ; 5.7 Summary ; 6 Delivery of Intoxicant ; 6.1 Introduction ; 6.2 Bioactivation |
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6.3 Delivery of Bioactivated Intoxicants 6.3.1 Dimethylnitrosamine ; 6.3.2 Monocrotaline ; 6.3.3 Tri 2-tolyl phosphate ; 6.3.4 Tetraethyllead ; 6.3.5 Hexachloro-1,3-butadiene ; 6.3.6 Metrifonate ; 6.4 Cytochrome P450s ; 6.5 Active Transport of Intoxicants ; 6.5.1 Paraquat ; 6.5.2 Beryllium ; 6.6 Biliary Excretion and Enterohepatic Circulation ; 6.7 Methods to Establish if In Vivo Bioactivation Occurs ; 6.8 Discussion ; 6.9 Summary ; 7 Initiating Reactions with Targets ; 7.1 Introduction ; 7.2 Intoxicants which Affect Oxidative Energy Conservation (Many Tissues) |
| Notes |
7.3 Pyrethroids (Nervous System) |
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Print version record |
| Genre/Form |
handbooks.
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Handbooks and manuals
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Handbooks and manuals.
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Guides et manuels.
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| Form |
Electronic book
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| ISBN |
9780203211212 |
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0203211219 |
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