Title The epigenome and developmental origins of health and disease / edited by Cheryl S. Rosenfeld

Published London : Academic Press, an imprint of Elsevier, [2016]

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Description 1 online resource Contents The developmental origins of health and disease (DOHaD) concept : past, present, and future / Peter D. Gluckman, Tatjana Buklijas and Mark A. Hanson -- Historical perspective of developmental origins of health and disease in humans / Lewis P. Rubin -- DOHaD and the periconceptional period, a critical window in time / Congshan Sun, Miguel A. Velazquez and Tom P. Fleming -- Introduction to epigenetic mechanisms : the probable common thread for various developmental origins of health and diseases effects / Martha Susiarjo -- Perinatal neurohormonal programming and endocrine disruption / Cheryl S. Rosenfeld -- Parental nutrition and developmental origins of health and disease / Miguel A. Velazquez, Congshan Sun and Tom P. Fleming -- Maternal prenatal stress and the developmental origins of mental health : the role of epigenetics / Kieran J. O'Donnell and Vivette Glover -- Epigenetics in the developmental origin of cardiovascular disorders / Jeffrey S. Gilbert -- Developmental effects of endocrine-disrupting chemicals in the ovary and on female fertility / Mehmet Uzumcu and Aparna Mahakali Zama -- Developmental and eipigenetic origins of male reproductive pathologies / Carlos Guerrero-Bosagna -- Developmental origins of childhood asthma and allergic conditions : is there evidence of epigenetic regulation? / Steve Turner -- Immune disorders, epigenetics, and the developmental origins of health and disease / Rodney R. Dietert and Amrie C. Grammer -- Neurobehavioral disorders and developmental origins of health and disease / Curt A. Sandman, Quetzal A. Class, Laura M. Glynn and Elysia Poggi Davis -- Metabolic disorders and developmental origins of health and disease / Sara E. Pinney The developmental origins of renal dysfunction / James S.M. Cuffe, Sarah L. Walton and Karen M. Moritz -- Cancer and developmental origins of health and disease : epigenetic reprogramming as a mediator / Shuk-Mei Ho, Ana Cheong, Sarah To, Vinothini Janakiram, Pheruza Tarapore and Yuet-Kin Leung -- Epigenetic regulation of gastrointestinal epithelial barrier and developmental origins of health and disease / J.P. Lallès, C. Michel, V. Theodorou and J.P. Segain -- How the father might epigenetically program the risk for developmental origins of health and disease effects in his offspring / Kristin E. Murphy, Timothy G. Jenkins and Douglas T. Carrell -- Linkage between in utero environmental changes and preterm birth / Markus Velten and Lynette K. Rogers -- Sexual dimorphism and DOHaD through the lens of epigenetics : genetic, ancestral, developmental, and environmental origins from previous to the next generation(s) / Claudine Junien, Sara Fneich, Polina Panchenko, Sarah Voisin and Anne Gabory -- Transgenerational epigenetic inheritance : past exposures, future diseases / Carlos Guerrero-Bosagna -- The placenta and developmental origins of health and disease / Jane K. Cleal and Rohan M. Lewis -- The moral and legal relevance of DOHaD effects for pregnant mothers / Michele Loi and Marianna Nobile -- Introduction to Moms in Motion (MIM) / Cheryl S. Rosenfeld -- Reversing harmful developmental origins of health and disease effects / Mei-Wei Chang, Susan Nitzke, Roger Brown, M Jean Brancheau Egan, Kobra Eghtedary and Cheryl S. Rosenfeld -- Informational resources for developmental origins of health and disease research / Cheryl S. Rosenfeld Summary The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (EBSCO, viewed October 14, 2015) Subject Human genome. Epigenetics. Medical genetics. Developmental biology. Diseases -- Causes and theories of causation. Disease susceptibility. Epigenesis, Genetic Developmental Biology Genome, Human Disease Susceptibility Prenatal Exposure Delayed Effects Genetics, Medical NATURE -- Animals -- Mammals. SCIENCE -- Life Sciences -- Zoology -- Mammals. Developmental biology Disease susceptibility Diseases -- Causes and theories of causation Epigenetics Human genome Medical genetics Form Electronic book Author Rosenfeld, Cheryl S., editor. LC no. 2015946467 ISBN 9780128016725 0128016728

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