| Description |
1 online resource (429 pages) |
| Contents |
Cover -- Half Title -- Title Page -- Copyright Page -- Contents -- Preface -- Acknowledgments -- Chapter 1: Genetic Diversity -- 1.1 Genetic Terminology -- The use of the terms genes and alleles varies, though they do have precise definitions -- 1.2 Genetic Variation -- Genetic variation can be measured by several methods -- Alleles on the same chromosome are physically linked and inherited as haplotypes -- Linkage disequilibrium promotes conservation of haplotypes in populations -- 1.3 Genetics and Evolution -- Mutation is the major cause of genetic variation |
|
Genetic variation caused by mutation alters allele frequencies in populations -- Migration and dispersal cause gene flow -- Allele frequencies can change randomly via genetic drift -- The thrifty gene hypothesis -- Natural selection acting on different levels of fitness affects the gene pool -- 1.4 Calculating Genetic Diversity: Determining Population Variability -- Genotype and allele frequencies illustrate genetic diversity -- Allele frequency refers to the numbers of alleles present in a population -- Heterozygosity provides a quantitative estimation of genetic variation |
|
The HWP is a complex but essential concept in population genetics -- Calculating expected genotype frequencies using the HWP -- Different populations may have different allele frequencies -- 1.5 Population Size and Structure -- Breeding population size is important in evolution -- Genetic variation is not always uniform in a population -- Wahlund's principle -- 1.6 The Mitochondrial Genome -- 1.7 Gene Expression and Phenotype -- Genetic variation is manifested in the phenotype -- Phenotypes are influenced by the environment -- 1.8 Epigenetics -- 1.9 Genomic Imprinting -- Conclusions |
|
Further Reading -- Chapter 2: Defining Complex Disease -- 2.1 Definition of a Genetically Complex Disease -- To fully understand complex disease it is important to deconstruct this definition -- 2.2 Chromosomal Diseases -- Changes in chromosome number cause serious genetic diseases -- Changes in chromosome structure can cause serious illness -- 2.3 Mendelian Diseases -- Mendelian diseases involve a single gene and show simple patterns of inheritance -- Penetrance is an important difference between Mendelian and complex diseases -- Some diseases have both Mendelian and complex characteristics |
|
Modifier genes may also confuse the picture -- Mendelian traits can be studied in families -- There are complications to Mendelian diseases -- 2.4 Variation in The Mitochondrial Genome is Associated with Disease -- Variation in the mtDNA has been widely associated and linked with many different diseases -- 2.5 De Novo Mutations and Human Disease -- 2.6 Three Different Types of Complex Disease -- Studying complex disease is different from studying Mendelian disease -- Monogenic complex diseases involve a single risk allele -- Oligogenic complex diseases involve several alleles |
| Notes |
Polygenic complex diseases involve many risk alleles |
|
Print version record |
| Subject |
Genetic disorders.
|
|
Disease susceptibility.
|
|
Genetic Diseases, Inborn
|
|
Disease Susceptibility
|
|
Disease susceptibility.
|
|
Genetic disorders.
|
| Form |
Electronic book
|
| Author |
Daly, Ann
|
|
Ermini, Luca
|
|
Bevitt, Debra
|
| ISBN |
9781317334255 |
|
1317334256 |
|
9780429258688 |
|
0429258682 |
|
9780815344919 |
|
0815344910 |
|
