| Description |
1 online resource |
| Contents |
Epigenetic gene expression -- an introduction / C. Ann Blakey and Michael D. Litt -- Histone modifications -- models and mechanisms / C. Ann Glakey and Michael D. Litt -- Genomic imprinting in mammals -- memories of generations past / Nora Engel -- Polycomb and Trithorax factors in transcriptional and epigenetic regulation / Priscilla Nga Ieng Lau and Chi Wai Eric So -- Chromatin dynamics and genome organization in development and disease / Changwang Deng, Bhavita Patel, Xiumei Lin, Yangqiu Li and Suming Huang -- ncRNA function in chromatin organization / Keith E. Giles, Jessica L. Woolnough and Blake Atwood -- Epigenetic gene regulation and stem cell function / Aissa Benyoucef and Marjorie Brand -- Epigenetic inheritance / Benjamin B. Mills, Christine M. McBride and Nicole C. Riddle -- Transgenerational epigenetic regulation by environmental factors in human diseases / Yuanyuan Li -- Identification of intergenic long noncoding RNA by deep sequencing / Gangqing Hu and Keji Zhao -- Regulation of erythroid cell differentiation by transcription factors, chromatin structure alterations, and noncoding RNA / Alex Xiucheng Fan, Mir A. Hossain, Jared Stees, Ekaterina Gavrilova and Jörg Bungert -- Genetically altered cancer epigenome Ming Tang, Huacheng Luo and Jianrong Lu -- Long noncoding RNAs and carcinogenesis Félix Recillas-Targa-- Epigenetics of physiological and premature aging Shrestha Ghosh and Zhongjun Zhou -- Epigentic effects of environment and diet / Jason O. Brant and Thomas P. Yang -- Epigenetic control of stress-induced apoptosis / Lei Zhou -- Structure, regulation, and function of TET family proteins / Xin Hu, Yun Chen and Zhizhuang Joe Zhao -- Epigenetic drugs for cancer therapy / Bowen Yan, Xuehui Li, Alta Johnson, Yurong Yang, Wei Jian and Yi Qiu |
| Summary |
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies |
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The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues |
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The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment |
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Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples |
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- Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies - Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring - Chapters are replete with clinical examples to empower the basic biology with translational significance - Offers more than 100 illustrations to distill key concepts and decipher complex science |
| Notes |
Includes index |
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Online resource; title from PDF title page (ScienceDirect, viewed November 4, 2015) |
| Subject |
Epigenetics.
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Gene expression.
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Genetic regulation.
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Gene Expression
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Gene Expression Regulation
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SCIENCE -- Life Sciences -- Biochemistry.
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Epigenetics
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Gene expression
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Genetic regulation
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| Genre/Form |
dissertations.
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Academic theses
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Academic theses.
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Thèses et écrits académiques.
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| Form |
Electronic book
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| Author |
Huang, Suming, editor
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Litt, Michael D., editor
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Blakey, C. Ann, editor
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| ISBN |
9780128004715 |
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0128004711 |
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0127999582 |
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9780127999586 |
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