| Description |
1 online resource (213 pages) |
| Contents |
Pain Genetics: Basic to Translational Science; Copyright; Contents; Contributors; Editors' Biographies; 1 How Do Pain Genes Affect Pain Experience?; Introduction; Variability in Pain Experience; Heritability of Pain: Historical Roots; Why is Pain Genetics Interesting and Potentially Useful?; What Are Pain Genes?; How Many Pain Genes Are There?; How Do Pain Genes Affect Pain Experience?; Direct Effects of Allelic Variation on Pain Mechanisms; Indirect Effects of Allelic Variation on Pain Mechanisms; Disease Susceptibility Genes Versus Pain Susceptibility Genes; Perspective; Acknowledgments |
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Long-Term Potentiation and Long-Term Depression in Neuropathic Pain in MammalsNeuropathic Pain in Drosophila; Conclusions; References; 3 Defining Human Pain Phenotypes for Genetic Association Studies; Introduction; What is a Pain Phenotype?; Pain Scaling; Heritability; Genotype-Phenotype Matching; Reliability and Temporal Stability; Clinical Phenotypes; Designing Clinical Pain Genetic Studies; The Heritability of Specific Clinical Pain Conditions; Experimental Phenotypes; The Heritability of Experimental Phenotypes; Extended Phenotypes; Practical Concerns; Conclusions |
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Conflict of Interest StatementReferences; 4 Genetic Contributions to Pain and Analgesia: Interactions with Sex and Stress; Introduction; Brief Overview of Sex and Gender Differences in Pain and Analgesia; Brief Overview of Stress and Pain/Analgesia; Sex X Gene Interactions in Pain and Analgesia; Sex Chromosome-Linked Genes; Genes Related to Hormone Function; Sex-Dependent Mechanisms: Qualitative Versus Quantitative Differences; Preclinical Findings; Human Findings; Translational Findings; Summary; References; 5 Abnormal Pain Conditions in Humans Related to Genetic Mutations |
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Introduction to SCN9A, NTRK1, and NGF and the Roles They Play in PainIntroduction to SCN9A and Its Omnipotent Role in Pain Sensing; Phenotypes Caused by SCN9A Mutations; SCN9A Gene; Pathogenic SCN9A Mutations; Nav1.7 Protein; The Role of SCN9A/Nav1.7 in Pain; Future Development of Nav1.7 Antagonists; Introduction to NTRK1 and Its Role in Development and Function in the Pain and Sympathetic Nervous Systems; Phenotype Caused by NTRK1 Gene Mutations (OMIM 256800); NTRK1 Gene; Pathogenic NTRK1 Mutations; TRKA Protein; Role of NTRK1/TRKA and NGF in Pain and the HSAN Phenotype |
| Summary |
Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for established researchers looking for a better understanding of the diverse strands of research going on in the area. With |
| Bibliography |
References2 Conservation of Pain Genes Across Evolution; Introduction; Anatomical Organization of Nociception Apparatus in Mammals and Drosophila; Acute Heat Pain in Mammals; Acute Heat Nociception in Drosophila; Mechanical Pain in Mammals; Mechanical Nociception in Drosophila; Chemical Nociception in Mammals; Chemical Nociception in Drosophila; Inflammatory Pain in Mammals; Persistent Pain in Drosophila; Neuropathic Pain in Mammals; Structural Reorganizations of Nerve Fibers in Neuropathic Pain; Mammalian Neuropathic Pain Genes That Are Conserved in Drosophila |
| Notes |
Future Drug Developments |
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Print version record |
| Subject |
Pain perception.
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Pain -- Treatment.
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Pain perception.
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Pain -- Treatment.
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| Form |
Electronic book
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| Author |
Diatchenko, Luda
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| ISBN |
9781118398883 |
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1118398882 |
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