| Description |
1 online resource (308 pages) |
| Series |
Epigenetics and Human Health |
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Epigenetics and human health.
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| Contents |
Preface; Contents; List of Contributors; Part I: Fetal Origins of Adult Disease Susceptibility; Chapter 1: Epigenetics: How Genes and Environment Interact; 1.1 Introduction; 1.2 Definition of Epigenetics; 1.3 Epigenetically Labile Genes; 1.3.1 Metastable Epialleles; 1.3.1.1 Nutritional Supplements; 1.3.1.2 Bisphenol A; 1.3.1.3 Low-Dose Ionizing Radiation; 1.3.2 Imprinted Genes; 1.3.2.1 Imprinting Evolution Theories; 1.3.2.2 Imprinting Mechanisms; 1.3.2.3 Imprinting and Disease Susceptibility; 1.3.2.4 The Imprintome; Human Imprintome Identification; 1.4 Conclusions; References |
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Chapter 2: Developmental Epigenomics and Metabolic Disease2.1 Introduction; 2.2 Developmental Plasticity; 2.2.1 Environmental Interactions During Development; 2.2.2 The Role of Epigenetics in Developmental Plasticity; 2.2.3 Epigenetics and Evolution; 2.2.3.1 Potential Role of Epigenetic Change in Evolutionary Processes; 2.3 Developmental Plasticity, Health, and Disease; 2.3.1 Developmental and Evolutionary Pathways to Disease; 2.3.2 Developmental Origins of Health and Disease; 2.3.3 Developmental Origins of Obesity and Related Metabolic Diseases; 2.3.3.1 Epigenetics: Experimental Evidence |
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2.3.3.2 Epigenetics: Clinical Evidence2.3.4 Epigenetic Contributions to the Developmental Origins of Other Disorders; 2.3.4.1 Early Life Stress; 2.3.4.2 Environmental Toxins; 2.4 Developmental Epigenomics; 2.4.1 Problems and Pitfalls; 2.4.2 The Potential of Developmental Epigenetics; 2.5 Final Comments; References; Chapter 3: Sculpting Our Future: Environmental Nudging of the Imprintome; 3.1 Introduction; 3.2 Genomic Imprinting; 3.3 The Imprintome; 3.4 The Early Origins of Disease; 3.5 Imprinted Genes and Early Origins; 3.6 Windows of Vulnerability During Reprogramming of the Imprintome |
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3.7 Environmental Influences In Utero Shift Methylation in the Imprintome3.7.1 The Imprintome and Folic Acid; 3.7.2 The Imprintome and Smoking; 3.7.3 The Imprintome and Antidepressant Use; 3.8 Breast Feeding May Counter Negative Environmental Effects on the Imprintome; 3.9 Childhood Exposure to Lead Induces Imprintome Methylation Alterations; 3.10 Implications of Nudging the Imprintome; 3.10.1 Perturbing Imprintome Function May Disrupt an Integrated Gene Network; 3.10.2 Long-Term Implications of Nudging Imprintome Function; 3.10.2.1 Costs to the Individual; 3.10.2.2 Costs to Society |
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3.11 Can Imprintome Deregulation Be Treated or Prevented?3.12 Conclusions; References; Part II: Epigenetics and Environmental Exposures; Chapter 4: Complex Phenotypes: Epigenetic Manifestation of Environmental Exposures; 4.1 Introduction; 4.2 Developmental Influences on the Epigenome; 4.2.1 Nutrition; 4.2.2 Behavior and Stress; 4.2.3 Chemical Toxicants; 4.2.4 Stochasticity; 4.3 Time Points of DNA Methylation Lability; 4.3.1 Germ Cell Methylation Reprogramming; 4.3.2 Zygotic Methylation Reprogramming; 4.3.3 Somatic Methylation Lability; 4.4 Vulnerable Genomic Structures |
| Summary |
There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embr |
| Notes |
4.4.1 Repetitive Elements |
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Print version record |
| Subject |
Medicine.
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Cancer -- Research.
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Human genetics.
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Medical genetics.
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Medicine
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Genetics, Medical
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medicines (material)
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medicine (discipline)
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Cancer -- Research
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Human genetics
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Medical genetics
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Medicine
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| Form |
Electronic book
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| Author |
Tyson, Frederick L
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| ISBN |
9783642233807 |
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3642233805 |
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