| Description |
1 online resource : illustrations (some color) |
| Series |
Epigenetics and human health |
|
Epigenetics and human health.
|
| Contents |
Fetal Origins of Adult Disease Susceptibility -- Epigenetics: How Genes and Environment Interact / Randy L. Jirtle -- Developmental Epigenomics and Metabolic Disease / Peter D. Gluckman, Felicia M. Low, Mark A. Hanson -- Sculpting Our Future: Environmental Nudging of the Imprintome / Susan K. Murphy, Cathrine Hoyo -- Epigenetics and Environmental Exposures -- Complex Phenotypes: Epigenetic Manifestation of Environmental Exposures / Christopher Faulk, Dana C. Dolinoy -- Epigenetic Effects of Ionizing Radiation / Olga Kovalchuk -- The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE-1 Retrotransposons by Environmental Injury / Kenneth S. Ramos [and others] -- Epigenetics, Gene Regulation, and Stem Cells -- Environmental Impact on Epigenetic Histone Language / John M. Denu -- Chromatin Structure and Gene Expression: Function Follows Form / Aleksandra B. Adomas, Paul A. Wade -- Epigenetics of Pluripotency / R. David Hawkins, Bing Ren -- Epigenetic Transgenerational Inheritance -- Transgenerational Epigenetic Inheritance in Drosophila / Luan Wang, Xiangyi Lu, Douglas M. Ruden -- Environmental Epigenetics and Epigenetic Transgenerational Inheritance / Michael K. Skinner -- The Nature of Human Transgenerational Responses / Marcus E. Pembrey, Lars O. Bygren, Jean Golding |
| Summary |
Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming |
| Analysis |
biomedische wetenschappen |
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biomedicine |
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neoplasms |
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moleculaire genetica |
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molecular genetics |
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humane genetica |
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human genetics |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
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Print version record |
| Subject |
Epidemiology.
|
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Human beings -- Effect of environment on.
|
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Epigenesis.
|
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Environment and Public Health
|
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Epigenomics
|
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Gene-Environment Interaction
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Epidemiology
|
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MEDICAL -- Epidemiology.
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MEDICAL -- Health Risk Assessment.
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Epidemiology
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Epigenesis
|
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Human beings -- Effect of environment on
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| Form |
Electronic book
|
| Author |
Jirtle, Randy L
|
|
Tyson, Frederick L., 1953-
|
| ISBN |
9783642233807 |
|
3642233805 |
|
