Limit search to available items
11 results found. Sorted by relevance | date | title .
Book Cover

Title Genetic influences on response to drug treatment for major psychiatric disorders / Janusz K. Rybakowski, Alessandro Serretti, editors
Published Cham : Springer, 2016


Description 1 online resource
Contents Introduction; Contents; Chapter 1: Pharmacogenetics of the Efficacy of Antipsychotic Drugs in Schizophrenia; 1.1 Introduction; 1.1.1 Pharmacogenetics of Antipsychotic Efficacy; 1.1.2 Clinical Response Phenotypes; 1.1.3 Research Strategies; 1.2 Pharmacogenetic and Pharmacogenomic Findings; 1.2.1 Candidate Gene Studies; Findings Related to Antipsychotic Efficacy; Findings in Targeted Neurotransmitters and Transporters; Findings in Metabolic Enzymes; Others; Findings Related to Antipsychotic-Induced Side Effects; Findings in Targeted Neurotransmitter Receptors and Transporters
Findings in Metabolic Enzymes; Others; 1.2.2 Genome-Wide Association Studies (GWAS); Findings Related to Antipsychotic Efficacy; Findings Related to Antipsychotic Side Effects; 1.3 Clinical Applications and Benefits of Pharmacogenetic Interventions; 1.3.1 Pharmacogenetic Findings as Biomarkers of Clinical Outcome; 1.3.2 Pharmacogenetic Tests for Prediction of Antipsychotic Response; 1.4 Conclusions; References; Chapter 2: Pharmacogenetics of Serious Antipsychotic Side Effects; 2.1 Background; 2.2 Common Side Effects; 2.2.1 Tardive Dyskinesia; Drug Metabolism Genes Neurotransmitter Genes; Dopamine System Genes; Serotonin System Genes; Oxidative Stress Genes; Other Genes; The Brain-Derived Neurotrophic Factor (BDNF); Cannabinoid Receptor 1 (CNR1); Dipeptidyl Peptidase-Like Protein 6 (DPP6); Heparan Sulphate Proteoglycan 2 (HSPG2), Perlecan; 2.2.2 Antipsychotic-Induced Weight Gain (AIWG); Neurotransmitter Genes; Serotonin System Genes; Dopamine System Genes; Leptin and Leptin Receptor; The Melanocortin 4 Receptor (MC4R); The Cannabinoid Receptor 1 (CNR1) and the Neuropeptide Y (NPY) Genes Mitochondrial Genes; Other Genes; 2.2.3 Clozapine-Induced Agranulocytosis (CIA); 2.3 Summary; References; Chapter 3: Pharmacogenetics of the Efficacy and Side Effects of Antidepressant Drugs; 3.1 Introduction; 3.1.1 Candidate Gene Studies; Monoaminergic System; Serotonin Transporter; Serotonin Receptors; Enzymes Responsible for Monoamine Metabolism; Glutamatergic System; Neuroplasticity; Inflammation; Cytokines; HPA Axis; Antidepressant Pharmacokinetics; Cytochrome P450 Genes; ABCB1 Gene; 3.1.2 Genome-Wide Association Studies (GWAS)
3.2 Clinical Applicability; 3.3 Conclusion; References; Chapter 4: Genomic Studies of Treatment Resistance in Major Depressive Disorder; 4.1 Background and Motivation; 4.2 Rationale for Genetic Investigation; 4.3 Association Studies of TRD; 4.4 Treatment Outcomes in TRD Cohorts; 4.5 Clinical Status; 4.6 Challenges and Future Directions; References; Chapter 5: Complementation of Pharmacogenetics with Biomarkers and Neuroimaging in Major Depression; 5.1 Introduction; 5.2 Blood-Based Biomarkers; 5.2.1 Inflammation; Predicting Treatment Response; 5.2.2 HPA Axis
Bibliography Includes bibliographical references
Notes Vendor-supplied metadata
Subject Psychiatry -- Alternative treatment
Nature and nurture.
Antipsychotic drugs.
Mental Disorders -- drug therapy
Mental Disorders -- genetics
Pharmacogenetics -- methods
Psychotropic Drugs -- therapeutic use
Antipsychotic Agents
Medical genetics.
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Antipsychotic drugs
Nature and nurture
Genre/Form Electronic books
Form Electronic book
Author Rybakowski, Janusz, editor.
Serretti, Alessandro, editor.
ISBN 9783319270401