| Description |
1 online resource (810 pages) : illustrations |
| Series |
AAPS Advances in the Pharmaceutical Sciences series ; v. 33 |
|
AAPS advances in the pharmaceutical sciences series ; v. 33.
|
| Contents |
Part I. Physiology and basic principles for drug handling by the CNS -- Anatomy and physiology of the blood-brain barriers* / N. Joan Abbott -- Increasing brain exposure of antibodies / Dominique Lesuisse -- Brain delivery of therapeutics via transcytosis: types and mechanisms of vesicle-mediated transport across the BBB / Arsalan S. Haqqani, Danica B. Stanimirovic -- Blood-arachnoid barrier as a dynamic physiological and pharmacological interface between cerebrospinal fluid and blood / Yasuo Uchida, Ryohei Goto, Takuya Usui, Masanori Tachikawa, Tetsuya Terasaki -- Quantitative and targeted proteomics of the blood-brain barrier: species and cell line differences / Shingo Ito, Takeshi Masuda, Sumio Ohtsuki -- Drug metabolism at the blood-brain and blood-CSF barriers / Jean-François Ghersi-Egea, Nathalie Strazielle, Xavier Declèves -- Part II. PK concepts and methods for studying CNS drug delivery -- Pharmacokinetic concepts in brain drug delivery / Margareta Hammarlund-Udenaes -- In Vitro models of CNS barriers / N. Joan Abbott, Siti R. Yusof, Andreas Reichel, Diana E. M. Dolman, Jane E. Preston -- Human in vitro blood-brain barrier models derived from stem cells / Koji L. Foreman, Sean P. Palecek, Eric V. Shusta -- Drug delivery to the brain: physiological concepts, methodologies, and approaches / Ramakrishna Samala, Behnam Noorani, Helen Thorsheim, Ulrich Bickel, Quentin Smith -- Principles of PET and its role in understanding drug delivery to the brain / Stina Syvänen, Roger N. Gunn, Lei Zhang -- Approaches towards prediction of CNS PK and PD / Elizabeth C. M. de Lange, Hsueh Yuan Chang, Dhaval Shah -- Part III. Industrial approaches for investigation of potential CNS drugs -- Drug discovery methods for studying brain drug delivery and distribution / Irena Loryan, Margareta Hammarlund-Udenaes -- Prediction of drug exposure in the brain from the chemical structure / Markus Fridén -- Part IV. Strategies for improved CNS drug delivery -- Intranasal Drug Delivery to the Brain / Jeffrey J. Lochhead, Niyanta N. Kumar, Geetika Nehra, Mallory J. Stenslik, Luke H. Bradley, Robert G. Thorne -- Strategies for improved CNS drug delivery blood-to-brain drug delivery using nanocarriers / Yang Hu, Pieter J. Gaillard, Jaap Rip, Margareta Hammarlund-Udenaes -- Transport of transferrin receptor-targeted antibodies through the blood-brain barrier for drug delivery to the brain / Torben Moos, Johann Mar Gudbergsson, Kasper Bendix Johnsen -- Drug delivery to the CNS in the treatment of brain tumors: the Sherbrooke experience / David Fortin -- Biophysical and clinical perspectives on blood-brain barrier permeability enhancement by ultrasound and microbubbles for targeted drug delivery / Dallan McMahon, Kullervo Hynynen -- Optimization of blood-brain barrier opening with focused ultrasound: the animal perspective / Elisa E. Konofagou -- Crossing the blood-brain barrier with AAVs: what’s after SMA? / Yujia Alina Chan, Benjamin E. Deverman -- Part V. CNS drug delivery in disease conditions -- Disease influence on BBB transport in neurodegeneration / Elizabeth C. M. de Lange -- The blood-brain barrier in stroke and trauma and how to enhance drug delivery / Richard F. Keep, Jianming Xiang, Ningna Zhou, Anuska V. Andjelkovic -- Drug delivery to primary and metastatic brain tumors: challenges and opportunities / Surabhi Talele, Afroz S. Mohammad, Julia A. Schulz, Bjoern Bauer, Anika M. S. Hartz, Jann N. Sarkaria et al |
| Summary |
"The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the bloodbrain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications."-- Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Drug delivery systems.
|
|
Absorption (Physiology)
|
|
Drug Delivery Systems
|
|
Adsorption
|
|
Absorption (Physiology)
|
|
Drug delivery systems
|
|
Absorció (Fisiologia)
|
|
Administració de medicaments.
|
| Genre/Form |
Llibres electrònics.
|
| Form |
Electronic book
|
| Author |
Lange, Elizabeth C. M. de, editor.
|
|
Hammarlund-Udenaes, Margareta, editor.
|
|
Thorne, Robert G., editor.
|
| ISBN |
9783030887735 |
|
3030887731 |
|
