| Description |
1 online resource |
| Contents |
Intro; TITLE PAGE; COPYRIGHT PAGE; CONTENTS; LIST OF CONTRIBUTORS; PREFACE; UNIT CONVERSIONS; PART 1 INTRODUCTION; CHAPTER 1 CHEMICAL ENGINEERING IN THE PHARMACEUTICAL INDUSTRY: AN INTRODUCTION; 1.1 GLOBAL IMPACT OF THE INDUSTRY; 1.2 INVESTMENTS IN PHARMACEUTICAL R 1.3 BEST SELLERS; 1.4 PHARMACEUTICAL RESEARCH AND DEVELOPMENT EXPENDITURES; 1.5 RECENT TRENDS FOR PHARMACEUTICAL DRUG AND MANUFACTURING; 1.6 CHEMICAL ENGINEERS SKILLED TO IMPACT FUTURE OF PHARMACEUTICAL INDUSTRY; REFERENCES; CHAPTER 2 CURRENT CHALLENGES AND OPPORTUNITIES IN THE PHARMACEUTICAL INDUSTRY; 2.1 INTRODUCTION |
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2.2 INDUSTRY-WIDE CHALLENGES2.3 OPPORTUNITIES FOR CHEMICAL ENGINEERS; 2.4 PROSPECTS FOR CHEMICAL ENGINEERS; REFERENCES; PART II MASS AND ENERGY BALANCES; CHAPTER 3 PROCESS SAFETY AND REACTION HAZARD ASSESSMENT; 3.1 INTRODUCTION; 3.2 GENERAL CONCEPTS; 3.3 STUDYING THE DESIRED SYNTHESIS REACTION AT LAB SCALE; 3.4 SCALE-UP OF THE DESIRED REACTION; 3.5 STUDYING THE DECOMPOSITION REACTION AT LAB SCALE; 3.6 REACTIVE WASTE; 3.7 CONTINUOUS PROCESSING; 3.8 OTHER POINTS TO CONSIDER; REFERENCES; CHAPTER 4 CALORIMETRIC APPROACHES TO CHARACTERIZING UNDESIRED REACTIONS; 4.1 INTRODUCTION; 4.2 BACKGROUND |
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4.3 THERMAL STABILITY SCREENING: DIFFERENTIAL SCANNING CALORIMETRY (DSC)4.4 PRESSURE SCREENING OF DECOMPOSITIONS: TECHNIQUES; 4.5 HAZARD SCENARIOS; 4.6 CASE STUDY 1: REACTION IN DIMETHYL SULFOXIDE (DMSO); 4.7 CASE STUDY 2: CONTINUOUS GAS GENERATION IN A WASTE STREAM CONTAINING CARBONATE; 4.8 CASE STUDY 3: EVALUATING A FUNCTIONAL GROUP; 4.9 CASE STUDY 4: USE OF THERMAL AND PRESSURE SCREENING TOOLS TO ASSESS AN mCPBA SOLUTION; 4.10 NOTATIONS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 5 CASE STUDY OF A BORANE-THF EXPLOSION; 5.1 INTRODUCTION; 5.2 BACKGROUND; 5.3 INVESTIGATION |
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5.4 ARC DATA OF BTHF FROM AN ADJACENT CYLINDER5.5 TEMPERATURE HISTORY OF THE BORANE-THF CYLINDERS; 5.6 HEAT LOSS MEASUREMENTS; 5.7 THERMAL STABILITY OF FRESH 2M BORANE-THF; 5.8 KINETICS OF DECOMPOSITION; 5.9 CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 6 ANALYTICAL ASPECTS FOR DETERMINATION OF MASS BALANCES; 6.1 INTRODUCTION; 6.2 THE USE OF ANALYTICAL METHODS APPLIED TO ENGINEERING; 6.3 METHODS USED AND BACKGROUND; 6.4 THINGS TO WATCH OUT FOR IN LC AND GC; 6.5 USE OF MULTIPLE ANALYTICAL TECHNIQUES; 6.6 CONCLUSION; REFERENCES; CHAPTER 7 QUANTITATIVE APPLICATIONS OF NMR SPECTROSCOPY |
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7.1 INTRODUCTION7.2 ONE-DIMENSIONAL NMR METHODS; 7.3 TWO-DIMENSIONAL NMR METHODS; 7.4 QUANTITATIVE NMR SPECTROSCOPY (qNMR); REFERENCES; PART III REACTION KINETICS AND MIXING PROCESSES; CHAPTER 8 REACTION KINETICS AND CHARACTERIZATION; 8.1 INTRODUCTION; 8.2 FUNDAMENTALS OF CHEMICAL REACTION KINETICS; 8.3 METHODS FOR THE CHARACTERIZATION OF CHEMICAL KINETICS; 8.4 TRANSFORMING EXPERIMENTAL DATA INTO A KINETIC MODEL; 8.5 EMERGING AREAS FOR INNOVATION AND IMPLEMENTATION; 8.6 CONCLUSIONS; 8.7 QUESTIONS; REFERENCES; CHAPTER 9 UNDERSTANDING FUNDAMENTAL PROCESSES IN CATALYTIC HYDROGENATION REACTIONS |
| Summary |
A guide to the development and manufacturing of pharmaceutical products written for professionals in the industry, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry is a practical book that highlights chemistry and chemical engineering. The book's regulatory quality strategies target the development and manufacturing of pharmaceutically active ingredients of pharmaceutical products. The expanded second edition contains revised content with many new case studies and additional example calculations that are of interest to chemical engineers. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API's) and 2) Drug Product Design, Development and Modeling. The active pharmaceutical ingredients book puts the focus on the chemistry, chemical engineering, and unit operations specific to development and manufacturing of the active ingredients of the pharmaceutical product. The drug substance operations section includes information on chemical reactions, mixing, distillations, extractions, crystallizations, filtration, drying, and wet and dry milling. In addition, the book includes many applications of process modeling and modern software tools that are geared toward batch-scale and continuous drug substance pharmaceutical operations. This updated second edition: " Contains 30new chapters or revised chapters specific to API, covering topics including: manufacturing quality by design, computational approaches, continuous manufacturing, crystallization and final form, process safety " Expanded topics of scale-up, continuous processing, applications of thermodynamics and thermodynamic modeling, filtration and drying " Presents updated and expanded example calculations " Includes contributions from noted experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduate students, and professionals in the field of pharmaceutical sciences and manufacturing, the second edition of Chemical Engineering in the Pharmaceutical Industry focuses on the development and chemical engineering as well as operations specific to the design, formulation, and manufacture of drug substance and products |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Copyright © 2019 by John Wiley & Sons 2019 |
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Online resource; title from PDF title page (EBSCO, viewed April 2, 2019) |
| Subject |
Pharmaceutical technology.
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Biochemical engineering.
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Chemical engineering.
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Technology, Pharmaceutical
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Chemical Engineering
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Drug Industry -- methods
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chemical engineering.
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MEDICAL -- Pharmacology.
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Biochemical engineering
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Chemical engineering
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Pharmaceutical technology
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| Form |
Electronic book
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| Author |
Ende, David J. am, editor.
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Ende, Mary T. am., editor
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| ISBN |
9781119285878 |
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1119285879 |
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9781119285885 |
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1119285887 |
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9781119285885 |
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