| Description |
1 online resource (xix, 433 pages) : illustrations (chiefly color) |
| Contents |
Conclusions -- List of abbreviations -- Acknowledgments -- References -- 4 -- Selectivity and trafficking of autophagic cargoes -- Introducing autophagy-the machinery and the mechanism -- Selective autophagy and cargo selection -- Ubiquitin and cargo recognition -- Selectivity determinants -- Selective autophagy receptors and the LC3-interacting region motif -- Soluble selective autophagy receptors -- Membrane-bound selective autophagy receptors -- A detailed view of some selective autophagy receptors -- SQSTM1/p62 -- Optineurin -- NBR1 -- ATG8 family (MAP1LC3A and GABARAP) -- The plausible role of membrane sources in selectivity -- Selective autophagy machinery and vesicular trafficking -- Conclusion -- References -- 5 -- The role of lysosomes in autophagy -- Lysosome overview -- Lysosomes as metabolic sensors -- Environment-sensing machinery at lysosomes -- Central elements for amino acid sensing at the lysosomal surface -- Rag GTPases -- v-ATPase -- Amino acid transporters -- Cholesterol sensing and lysosomal machinery -- Glucose sensing at the lysosome -- GTPase Rheb, core for growth factor, and energy sensing at the lysosomal surface -- Lysosomes regulate autophagy initiation -- Lysosomes orchestrate their own biogenesis to drive autophagy -- Lysosomal distribution regulates autophagy -- Concluding remarks -- References -- 6 -- Methods for measuring autophagy -- Measuring changes in levels of autophagic proteins to assess activity -- Assessing cellular signaling cascades indicative of autophagic activation -- Special considerations and issues -- Using microscopy to measure autophagy -- Measuring autophagy in vivo -- Measuring organelle-specific autophagy -- Concluding remarks -- References -- 7 -- Effects of physiologic inputs on autophagy -- Autophagy during fasting -- Autophagy during aging -- Regulation of autophagy during exercise |
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Circadian regulation of autophagy -- Sex differences in autophagy regulation -- References -- II Development -- 8 -- Autophagy in germ cells, stem cells, and induced pluripotent stem cells -- Introduction -- Overview of autophagy -- Autophagy during the formation of germ cells -- Insights from Caenorhabditis elegans -- Autophagy during mammalian oogenesis -- Establishing the follicular reserve -- Folliculogenesis and ovulation -- Formation and function of the corpus luteum -- In vitro fertility -- Human infertility -- Autophagy during mammalian spermatogenesis -- The process of spermatogenesis -- Remodeling mitochondria during spermatogenesis -- Autophagy in somatic cells supporting spermatogenesis -- Autophagy in embryonic stem cells -- The zygote-to-embryo transition -- Mitophagy and removal of mitochondrial DNA -- Adult multipotent stem cells -- Autophagy in induced pluripotent stem cells -- Autophagic remodeling to generate induced pluripotent stem cells -- Mitophagy and metabolic reprogramming of induced pluripotent stem cells -- Autophagy in cell fate decisions and differentiation -- Chaperone-mediated autophagy in embryonic stem cell differentiation -- Primary cilium-autophagy-Nrf2 axis -- The role of transcription factor EB -- Autophagy in stem cell aging and senescence -- References -- 9 -- Role of autophagy in embryogenesis -- Introduction -- Role of bulk autophagic degradation -- Caenorhabditis elegans -- Drosophila melanogaster -- Mouse -- Role of autophagy in early embryonic development -- Mechanism of autophagy induction during preimplantation embryonic development -- Role of autophagy in fetal development -- Role of selective autophagic degradation -- Maternal mitochondrial transmission -- Caenorhabditis elegans -- Drosophila melanogaster -- Mammals (mouse) -- Role of autophagy in gametogenesis -- Concluding remarks -- Acknowledgments |
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Release of substrates and metabolites through autophagy and cellular autodegradation pathways -- Targeted removal of damaged organelles via autophagy -- Cell plasticity and autophagy in tissue maintenance and disease -- Gastroenterological organs -- Lung and airway epithelium -- Kidney -- Cancer -- Conclusions -- References -- III Metabolic control and diabetes -- 12 -- Autophagy in the liver -- General liver anatomy and functions -- Anatomy of the liver -- Functions of the liver -- Physiological role of autophagy in the liver -- Brief overview of autophagy -- Hepatic autophagy dynamic responsiveness -- Endocrine, nutrient, and neural regulation -- Circadian regulation -- Regulation of autophagy in the hepatocyte -- Hepatic autophagy-mediated lipid homeostasis -- Context-dependent role of autophagy in lipid homeostasis -- Reciprocal interaction between autophagy and anabolism -- Role of autophagy in the immune system -- Hepatic autophagy in obesity and nonalcoholic fatty liver disease -- Nonhepatocyte roles of autophagy in the liver -- Hepatic stellate cells -- Kupffer cells -- Endothelial cells -- Cholangiocytes -- Conclusion and future perspectives -- References -- 13 -- Autophagy in adipose tissue -- Introduction -- Autophagy and adipose tissue development and maintenance -- Autophagy and adipogenesis -- Autophagy and lipogenesis -- Autophagy/lipophagy and lipolysis -- Autophagy/mitophagy and brown and beige fat thermogenesis -- Adipose autophagy in obesity and diabetes -- Human studies -- Animal studies -- Adipose lysosomal function in obesity and diabetes -- Autophagy and lipodystrophy -- Acknowledgments -- References -- 14 -- Autophagy in the pancreas -- Introduction -- Autophagy in the exocrine pancreas -- Autophagy is critical for maintenance of normal exocrine function -- A role for autophagy in the pathogenesis of pancreatitis? |
| Summary |
"Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. The book covers the history, trajectory of the research field, mechanisms of autophagy, and its regulation, developmental aspects, including stem cells, embryogenesis, hematopoiesis and paligenosis and focus on several systems, including Metabolic control and Diabetes, Cardiovascular, Nervous, Immune, Gastrointestinal, and Skeletal. The final chapters provide additional disease considerations, covering cancer, longevity, disease mechanisms, and the therapeutic targeting of autophagy. This book is invaluable to anyone looking for a broader understanding of autophagy outside their specific field"--Provided by publisher |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Description based on print version record |
| Subject |
Autophagic vacuoles.
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Homeostasis.
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Cell death.
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Homeostasis
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Cell death
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Autophagic vacuoles
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Homeostasis
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| Form |
Electronic book
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| Author |
Rothermel, Beverly A., editor.
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Diwan, Abhinav, editor.
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| ISBN |
9780128220047 |
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012822004X |
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