| Description |
1 online resource : illustrations |
| Contents |
880-01 Cover; Title Page; Copyright Page; Contents; List of Contributors; Chapter 1 -- The multitude of therapeutic targets in neurodegenerative proteinopathies; Protein Misfolding and Aggregation; Mechanism of Assembly; Prion-Like Propagation of Protein Assemblies; Propagation Routes of Pathogenic Protein Aggregates; Limiting Steps in the Propagation of Pathogenic Protein Assemblies; Therapeutic Strategies Targeting the Physiological Levels of Aggregation-Prone Proteins Involved in Neurodegeneration |
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880-01/(S Lowering α-synuclein expression levelsDirect inhibition of α-synuclein aggregation; Stabilizing Membrane Interactions; Conclusions; References; Chapter 3 -- Neuroinflammation as a therapeutic target in neurodegenerative diseases; Introduction; The Global Burden of Neurodegenerative Diseases and the Challenge of Developing Effective Therapeutics; Glial Cells in CNS Development, Homeostasis, and Pathology; Microglia; Astrocytes; Oligodendrocytes and Ependymal Cells; Chronic Neuroinflammation as a Common Pathophysiological Mediator in Progressive Neurodegenerative Diseases |
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Therapeutic Strategies Targeting the Misfolding and Aggregation of Proteins Involved in NeurodegenerationTherapeutic Strategies Targeting the Accumulation of Misfolded Pathologic Protein Aggregates; Therapeutic Strategies Targeting the Cell-to-Cell Propagation of Pathogenic Protein Aggregates; Therapeutic Strategies Aimed at Restoring the Damage Pathogenic Protein Aggregates Induce; Therapeutic Strategies Targeting Misfolded Pathologic Protein Aggregate-Mediated Neuroinflammation; Limitations of the Different Therapeutic Strategies; Acknowledgments; References |
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Mechanisms of Neuroinflammation-Mediated NeurodegenerationAlzheimer's Disease; Parkinson's Disease; Amyotrophic Lateral Sclerosis; Huntington's Disease; Frontotemporal Dementia and Lewy Body Dementia; Therapeutic Strategies Targeting Neuroinflammation in Progressive Neurodegenerative Diseases; Future Perspectives; Conclusions; References; Chapter 4A -- Stem cells in neurodegeneration: mind the gap; Introduction; Part I: Stem Cells; Genome Editing of Stem Cells; The Generation of Specific Cell Types; Part II: Stem Cells as Regenerative Therapy; Clinical Translation and Immunology |
| Summary |
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. This book provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress and summarizes how patients are treated today, providing a glance at future disease management. This book includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Vendor-supplied metadata |
| Subject |
Nervous system -- Diseases -- Treatment
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Nervous system -- Degeneration.
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Neurodegenerative Diseases -- therapy
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Nervous system -- Degeneration
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Nervous system -- Diseases -- Treatment
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| Genre/Form |
Electronic books
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| Form |
Electronic book
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| Author |
Baekelandt, Veerle, editor
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Lobbestael, Evy, editor
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| LC no. |
2016960656 |
| ISBN |
9780128052662 |
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012805266X |
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