Title Genomics, circuits, and pathways in clinical neuropsychiatry / edited by Thomas Lehner, Bruce L. Miller, Matthew W. State

Published [London, UK] : Academic Press is an imprint of Elsevier, 2016

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Description 1 online resource Contents Machine generated contents note: 1.The Newly Emerging View of the Genome -- Introduction / Christopher E. Mason / Stephan J. Sanders -- Conceptualizing DNA / Christopher E. Mason / Stephan J. Sanders -- Information Flow in Biological Systems / Christopher E. Mason / Stephan J. Sanders -- Key Definitions / Christopher E. Mason / Stephan J. Sanders -- Cis and Trans / Christopher E. Mason / Stephan J. Sanders -- Gene / Christopher E. Mason / Stephan J. Sanders -- Transcript / Christopher E. Mason / Stephan J. Sanders -- High-Throughput Sequencing / Christopher E. Mason / Stephan J. Sanders -- The Genome (DNA) / Christopher E. Mason / Stephan J. Sanders -- Visualizing the Genome / Christopher E. Mason / Stephan J. Sanders -- Large-Scale Structures in the Genome / Christopher E. Mason / Stephan J. Sanders -- Telomeres / Christopher E. Mason / Stephan J. Sanders -- Subtelomeres / Christopher E. Mason / Stephan J. Sanders -- Centromeres / Christopher E. Mason / Stephan J. Sanders Note continued: Small-Scale Structures in the Genome / Christopher E. Mason / Stephan J. Sanders -- Protein-Coding Genes / Christopher E. Mason / Stephan J. Sanders -- Noncoding Transcripts/Genes / Christopher E. Mason / Stephan J. Sanders -- Enhancers / Christopher E. Mason / Stephan J. Sanders -- Silencers / Christopher E. Mason / Stephan J. Sanders -- Insulators / Christopher E. Mason / Stephan J. Sanders -- Repetitive Elements / Christopher E. Mason / Stephan J. Sanders -- Multiple Roles / Christopher E. Mason / Stephan J. Sanders -- Variation in the Genome / Christopher E. Mason / Stephan J. Sanders -- Entire Chromosomes / Christopher E. Mason / Stephan J. Sanders -- Structural Variation / Christopher E. Mason / Stephan J. Sanders -- Insertions and Deletions / Christopher E. Mason / Stephan J. Sanders -- Single-Nucleotide Variants / Christopher E. Mason / Stephan J. Sanders -- Loss-of-Function Variants / Christopher E. Mason / Stephan J. Sanders Note continued: Ethnicity and Population Frequency of Variants in the Genome / Christopher E. Mason / Stephan J. Sanders -- Variation in Complex and Mendelian Disorders / Christopher E. Mason / Stephan J. Sanders -- Chromatin (DNA, RNA, and Protein) and Epigenetics / Christopher E. Mason / Stephan J. Sanders -- Chromatin State / Christopher E. Mason / Stephan J. Sanders -- Heterochromatin / Christopher E. Mason / Stephan J. Sanders -- Euchromatin / Christopher E. Mason / Stephan J. Sanders -- DNA Methylation / Christopher E. Mason / Stephan J. Sanders -- Histone Proteins / Christopher E. Mason / Stephan J. Sanders -- Chromatin Remodelers / Christopher E. Mason / Stephan J. Sanders -- Transcription Factors / Christopher E. Mason / Stephan J. Sanders -- Cofactors / Christopher E. Mason / Stephan J. Sanders -- Elongation Factors / Christopher E. Mason / Stephan J. Sanders -- Cohesins / Christopher E. Mason / Stephan J. Sanders Note continued: Regulatory Complexes / Christopher E. Mason / Stephan J. Sanders -- Preinitiation Complex (PIC) / Stephan J. Sanders / Christopher E. Mason -- Proximal Promoter-Pausing Complexes / Christopher E. Mason / Stephan J. Sanders -- Elongation Complex / Christopher E. Mason / Stephan J. Sanders -- Transcription (RNA) / Christopher E. Mason / Stephan J. Sanders -- Posttranscriptional mRNA Modifications / Christopher E. Mason / Stephan J. Sanders -- Epitranscriptome / Christopher E. Mason / Stephan J. Sanders -- RNA Editing / Christopher E. Mason / Stephan J. Sanders -- RNA Processing / Christopher E. Mason / Stephan J. Sanders -- Translation / Christopher E. Mason / Stephan J. Sanders -- Posttranslational Modifications / Christopher E. Mason / Stephan J. Sanders -- Summary / Christopher E. Mason / Stephan J. Sanders -- References / Christopher E. Mason / Stephan J. Sanders Note continued: 2.Contribution of Genetic Epidemiology to Our Understanding of Psychiatric Disorders / Christopher E. Mason / Stephan J. Sanders -- Introduction / Alison K. Merikangas / Kathleen R. Merikangas -- Background: Epidemiology / Alison K. Merikangas / Kathleen R. Merikangas -- Contributions to Psychiatry / Alison K. Merikangas / Kathleen R. Merikangas -- Genetic Epidemiology / Alison K. Merikangas / Kathleen R. Merikangas -- Family Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Twin Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Adoption Studies / Alison K. Merikangas / Kathleen R. Merikangas -- Genetic Epidemiology of Psychiatric Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Neurodevelopmental Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Eating Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Mood Disorders / Alison K. Merikangas / Kathleen R. Merikangas Note continued: Anxiety Disorders: Panic Disorder / Alison K. Merikangas / Kathleen R. Merikangas -- Obsessive-Compulsive Disorder / Alison K. Merikangas / Kathleen R. Merikangas -- Substance Use Disorders / Alison K. Merikangas / Kathleen R. Merikangas -- Summary / Alison K. Merikangas / Kathleen R. Merikangas -- Applications of Genetic Epidemiology in Molecular Era / Alison K. Merikangas / Kathleen R. Merikangas -- Study Designs and Samples / Alison K. Merikangas / Kathleen R. Merikangas -- Statistical Approaches to Estimate Genetic Influence / Alison K. Merikangas / Kathleen R. Merikangas -- Phenotypes: Moving Beyond Dichotomous Classification / Alison K. Merikangas / Kathleen R. Merikangas -- Incorporation of Environmental Factors / Alison K. Merikangas / Kathleen R. Merikangas -- Combining Genetic and Environmental Factors / Alison K. Merikangas / Kathleen R. Merikangas -- Team Science / Alison K. Merikangas / Kathleen R. Merikangas Note continued: References / Alison K. Merikangas / Kathleen R. Merikangas -- 3.Natural Selection and Neuropsychiatric Disease: Theory, Observation, and Emerging Genetic Findings / Alison K. Merikangas / Kathleen R. Merikangas -- Introduction / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Epidemiology of Neuropsychiatric Disease / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Theoretical Considerations / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Hypothesis Testing: Epidemiology and Emerging Genetic Data / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Mendelian Randomization and Polygenic Risk / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- De Novo Mutation and Mutation-Selection Balance / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Conclusions / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- References / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson Note continued: 4.Genome Tools and Methods: Rare Genetic Variation / Mark J. Daly / Benjamin M. Neale / Elise B. Robinson -- Rare Variants in Psychiatric Disease / Jonathan Sebat / Daniel J. Barrera -- Genetic Variation / Daniel J. Barrera / Jonathan Sebat -- Modern Technologies for Discovery of Rare Variants / Jonathan Sebat / Daniel J. Barrera -- Microarray Technology and Large-Scale Copy Number Variants in Neurodevelopmental and Neuropsychiatric Disease / Jonathan Sebat / Daniel J. Barrera -- Copy Number Variant Studies of Disease / Jonathan Sebat / Daniel J. Barrera -- Studies of De Novo Mutation in Trio Families / Jonathan Sebat / Daniel J. Barrera -- Case-Control Studies / Jonathan Sebat / Daniel J. Barrera -- Analysis Strategies / Daniel J. Barrera / Jonathan Sebat -- Genome / Daniel J. Barrera / Jonathan Sebat -- Pathways / Daniel J. Barrera / Jonathan Sebat -- Genes / Daniel J. Barrera / Jonathan Sebat -- SNVs / Daniel J. Barrera / Jonathan Sebat Note continued: Detection of Rare Genetic Variation by High-Throughput Sequencing / Daniel J. Barrera / Jonathan Sebat -- Exome / Daniel J. Barrera / Jonathan Sebat -- Gene Panels / Daniel J. Barrera / Jonathan Sebat -- Whole Genome Sequencing / Daniel J. Barrera / Jonathan Sebat -- Rare Genetic Variation in Noncoding DNA: A New Frontier / Daniel J. Barrera / Jonathan Sebat -- Rare Genetic Variants and the Potential to Affect Clinical Care / Daniel J. Barrera / Jonathan Sebat -- References / Daniel J. Barrera / Jonathan Sebat -- 5.Neuroepigenomics and Human Disease / Daniel J. Barrera / Jonathan Sebat -- Epigenetics / John M. Greally / Eric J. Nestler -- Epigenetics in Neurobiological Research / John M. Greally / Eric J. Nestler -- The Genomic Context of Transcriptional and Epigenetic Mechanisms / John M. Greally / Eric J. Nestler -- Transcriptional and Epigenetic Regulatory Mechanisms / John M. Greally / Eric J. Nestler Note continued: Epigenetic Perturbation and Epigenome-Wide Assays / John M. Greally / Eric J. Nestler -- Cell Type Choices in Neuroepigenomic Studies / John M. Greally / Eric J. Nestler -- Interaction of the Genome With the Epigenome / John M. Greally / Eric J. Nestler -- Epigenetics Mechanisms of Brain Diseases: General Principles and Future Directions / John M. Greally / Eric J. Nestler -- References / Eric J. Nestler / John M. Greally -- 6.Bioinformatics in Neuropsychiatric Genomics / John M. Greally / Eric J. Nestler -- What is Bioinformatics? / Shaun M. Purcell -- Databases / Shaun M. Purcell -- Methods / Shaun M. Purcell -- Tools / Shaun M. Purcell -- Standards / Shaun M. Purcell -- Summary / Shaun M. Purcell -- List of URLs / Shaun M. Purcell -- Core Genomic Databases and Portals / Shaun M. Purcell -- Genome Browsers / Shaun M. Purcell -- Genetic Variation / Shaun M. Purcell -- Gene Expression Resources / Shaun M. Purcell Note continued: Programming Environments for Bioinformatics / Shaun M. Purcell -- Genetic Linkage, Association, and Variation Detection / Shaun M. Purcell -- Network and Pathway Analysis / Shaun M. Purcell -- Rare Variant Detection and Annotation / Shaun M. Purcell -- Identifiers, Ontologies, and Standards / Shaun M. Purcell -- Psychiatric/Neuroscience Projects / Shaun M. Purcell -- References / Shaun M. Purcell -- 7.Imaging Genomics And Enigma / Shaun M. Purcell -- Introduction / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Power of MRI / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- What Is Imaging Genomics? / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- The Endophenotype Concept and Biomarkers / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Mapping Brain Diseases in Neurology / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad Note continued: MRI Versus Cellular Measures / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Mapping Brain Disorders: Psychiatry / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Psychiatric Neuroimaging Expands Worldwide / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Meta-Analysis / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- ENIGMA Studies of Brain Disease / Neda Jahanshad / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein -- Defusing Controversy With Meta-Analysis / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Imaging Genomics and Genome-Wide Association Studies / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genetic Influences on the Brain / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genes and Disease Risk / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad Note continued: Manhattan Plots / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Candidate Genes and Genome-Wide Association Studies / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Genome-Wide Significance / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Formation of ENIGMA in 2009 / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Surprises From Imaging Genomics Consortia / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Other Neuroimaging Methods / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Multivariate Imaging Genomics and Big Data / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Searching the Brain for Gene Effects / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Cooperative Machine Learning / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad Note continued: Conclusions / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Acknowledgments / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- References / Neda Jahanshad / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein -- 8.Brain in a Dish: Stem Cell Technologies to Study Disorders of the Central Nervous System / Paul M. Thompson / Derrek P. Hibar / Jason L. Stein / Neda Jahanshad -- Generating Induced Pluripotent Stem Cells / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Progress in Modeling Human Central Nervous System Pathology: Neurodevelopmental Disorders / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Rett Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri Note continued: Fragile X Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Angelman Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Timothy Syndrome / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Contribution of Different Cell Types to Neurodevelopmental Disorders / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- The Next Step of Induced Pluripotent Stem Cells: Three-Dimensional Cultures and Mini-Brains / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri Note continued: Limitations of Induced Pluripotent Stem Cell Model / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Genome Editing: Creating Diseased Embryonic Stem Cells / Alysson R. Muotri / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi -- Drug Discovery With Induced Pluripotent Stem Cells / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Conclusions / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- References / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri Note continued: 9.Association Strategies / Cleber A. Trujillo / Priscilla D. Negraes / Branka Hrvoj-Mihic / Mauro F.C. Lins / Katerina Semendeferi / Alysson R. Muotri -- Common Variants / Benjamin M. Neale -- Rare Variants / Benjamin M. Neale -- Conclusions / Benjamin M. Neale -- Acknowledgments / Benjamin M. Neale -- References / Benjamin M. Neale -- 10.Reconstructing Causal Network Models of Human Disease / Benjamin M. Neale -- Introduction / Eric E. Schadt -- Modeling Biological Data / Eric E. Schadt -- Causality as a Statistical Inference / Eric E. Schadt -- From Assessing Causal Relationships Among Trait Pairs to Predictive Gene Networks / Eric E. Schadt -- Building From the Bottom Up or Top Down? / Eric E. Schadt -- An Integrative Genomics Approach to Constructive Predictive Network Models / Eric E. Schadt -- Integrating Genetic Data as a Structure Before Enhancing Causal Inference in the Bayesian Network Reconstruction Process / Eric E. Schadt Note continued: Incorporating Other -Omics Data as Network Priors in the Bayesian Network Reconstruction Process / Eric E. Schadt -- Elucidating the Complexity of Human Disease: From the Metabolic to the Psychiatric / Eric E. Schadt -- Application of Predictive Network Models to High-Throughput Screening / Eric E. Schadt -- Conclusion and Future Directions / Eric E. Schadt -- References / Eric E. Schadt -- 11.Gene Networks in Neuropsychiatric Disease / Eric E. Schadt -- Introduction / Neelroop N. Parikshak / Daniel H. Geschwind -- RNA, Protein, and Epigenetic Molecular Levels in Neurobiology / Neelroop N. Parikshak / Daniel H. Geschwind -- The Challenge of Spatial and Temporal Heterogeneity in the Central Nervous System / Neelroop N. Parikshak / Daniel H. Geschwind -- Gene Networks Provide a Framework for Neurobiological Interpretation / Neelroop N. Parikshak / Daniel H. Geschwind Note continued: Gene Networks in Neuropsychiatric Disorders / Neelroop N. Parikshak / Daniel H. Geschwind -- Genome-Wide Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Seed-Based Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Protein-Protein Interaction Networks / Neelroop N. Parikshak / Daniel H. Geschwind -- Integrative Network Approaches / Neelroop N. Parikshak / Daniel H. Geschwind -- Themes From Cross-Method Comparisons / Neelroop N. Parikshak / Daniel H. Geschwind -- Conclusions and Future Directions / Neelroop N. Parikshak / Daniel H. Geschwind -- Acknowledgments / Neelroop N. Parikshak / Daniel H. Geschwind -- References / Neelroop N. Parikshak / Daniel H. Geschwind -- 12.Somatic Mosaicism and Neurological Diseases / Neelroop N. Parikshak / Daniel H. Geschwind -- Introduction / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh Note continued: Cortical Clonal Architecture and Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Somatic Mutations in Normal Brain / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Somatic Mutation in Neurological Disease / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- "Brain-Only" Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- "Second-Hit" Mutations Produce Mosaicism / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Neurodevelopmental Disorders Caused by Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Neurological Diseases Caused or Modulated by Somatic Mutations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Types of Somatic Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Large-Scale Chromosomal Abnormalities / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh Note continued: Copy Number Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Single-Nucleotide Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Tissue Type Considerations / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Tools to Study Somatic Variation in the Brain / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Copy Number Variants / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Single-Nucleotide Variants, Including Insertions and Deletions / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Conclusion / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- Acknowledgments / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- References / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh -- 13.The Molecular Landscape of the Developing Human Central Nervous System / Saumya S. Jamuar / Alissa M. D'Gama / Christopher A. Walsh Note continued: Introduction / Nenad Sestan / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li -- The Cellular and Structural Complexity of the Human Brain / John C. Silbereis / Ying Zhu / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- General Principles of Human Neocortical Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Neurogenesis and Neuronal Migration / John C. Silbereis / Ying Zhu / Sirisha Pochareddy / Nenad Sestan / Mingfeng Li -- Glial Cell Genesis and Differentiation / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Neural Circuit Formation and Developmental Plasticity / Ying Zhu / John C. Silbereis / Mingfeng Li / Sirisha Pochareddy / Nenad Sestan -- Regional Patterning and Interhemispheric Lateralization / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan Note continued: Transcriptional Landscape of the Developing Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Spatiotemporal Dynamics of Human Brain Transcriptome / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Transcriptional Architecture Underlying Cellular and Regional Specification of the Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Transcriptional Insights Into Maturational Trajectories of the Human Neocortex / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Interhemispheric Neocortical Transcriptomes / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Epigenomic and Regulatory Landscapes of the Developing Human Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan Note continued: DNA Methylation in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Histone Modification and Functional Regulatory Elements in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Noncoding RNAs in Human Brain Development / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Insights Into Psychiatric and Neurological Disorders / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Conclusions and Future Directions / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Acknowledgments / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- References / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan Note continued: 14.Optogenetic Approaches to Neural Circuit Analysis in the Mammalian Brain / Ying Zhu / John C. Silbereis / Sirisha Pochareddy / Mingfeng Li / Nenad Sestan -- Introduction / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Tools for Functional Neural Circuit Dissection / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Definition of Opsins / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Expression of Opsins in the Mammalian Brain / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Cell Type-Specific Targeting of Opsins Using Promoters / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Cell Type-Specific Targeting of Opsins Using Cre/loxP Recombinase / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Intersectional Approaches / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Functional Circuit Analysis / Stephan Lammel / Gul Dolen / Robert C. Malenka Note continued: Ex Vivo Synaptic Input Specificity / Stephan Lammel / Gul Dolen / Robert C. Malenka -- In Vivo Neural Circuit Analysis in Freely Moving Animals / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Translational Medicine / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Conclusions / Stephan Lammel / Gul Dolen / Robert C. Malenka -- References / Stephan Lammel / Gul Dolen / Robert C. Malenka -- 15.Brain Imaging With Magneto-encephalography During Rest and During Speech and Language Processing / Stephan Lammel / Gul Dolen / Robert C. Malenka -- Brain Imaging With Magnetoencephalography (MEG) / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Sensing the Brain's Magnetic Fields / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- From Sensing to Imaging / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel Note continued: Forward Models Describing Brain Activity and Measurements / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Inverse Models for Reconstructing Brain Activity From Measurements / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Sources of Noise in Magnetoencephalography / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Temporal and Spatial Resolution of Magnetoencephalography Imaging / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- From Single-Subject Reconstructions to Group-Level Inference / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Resting Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel Note continued: Activation Magnetoencephalography Studies in Aging and Dementia / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- Summary and Conclusions / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- References / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- 16.Resting-State Functional MRI: A Novel Tool for Understanding Brain Networks in Neuropsychiatric Disorders / Srikantan S. Nagarajan / Kamalini G. Ranasinghe / Keith A. Vossel -- A Brief History of Resting-State Functional MRI / Michael Greicius -- Healthy Skepticism Drives Deeper Explorations / Michael Greicius -- Attributes of Resting-State Networks / Michael Greicius -- Default-Mode and Salience Networks / Michael Greicius -- Applications to Brain Disease / Michael Greicius -- Future Directions / Michael Greicius -- References / Michael Greicius -- 17.Neuroimaging Advances in Alzheimer's Disease / Michael Greicius Note continued: Abbreviations / Daniel R. Schonhaut / Gil D. Rabinovici -- Introduction / Daniel R. Schonhaut / Gil D. Rabinovici -- Alzheimer's Disease Defined / Daniel R. Schonhaut / Gil D. Rabinovici -- Imaging Characteristics of Alzheimer's Disease / Daniel R. Schonhaut / Gil D. Rabinovici -- Structural MRI / Daniel R. Schonhaut / Gil D. Rabinovici -- Functional MRI / Daniel R. Schonhaut / Gil D. Rabinovici -- [18F]Fluoro-2-Deoxy-o-Glucose Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Amyloid Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Tau Positron Emission Tomography / Daniel R. Schonhaut / Gil D. Rabinovici -- Progression of Neuroimaging Abnormalities: An Amyloid Cascade? / Daniel R. Schonhaut / Gil D. Rabinovici -- Preclinical Alzheimer's Disease / Daniel R. Schonhaut / Gil D. Rabinovici -- Mild Cognitive Impairment / Daniel R. Schonhaut / Gil D. Rabinovici Note continued: Dementia and Limitations of the Amyloid Cascade Hypothesis / Daniel R. Schonhaut / Gil D. Rabinovici -- Underlying Mechanisms of Alzheimer's Disease Pathology / Daniel R. Schonhaut / Gil D. Rabinovici -- Amyloid Plaques Form in Regional Hubs / Daniel R. Schonhaut / Gil D. Rabinovici -- Tau Spreads Through Functional Networks / Daniel R. Schonhaut / Gil D. Rabinovici -- Conclusions / Daniel R. Schonhaut / Gil D. Rabinovici -- References / Daniel R. Schonhaut / Gil D. Rabinovici -- 18.Progressive Supranuclear Palsy and Related Parkinsonian Disorders / Daniel R. Schonhaut / Gil D. Rabinovici -- Introduction / Jesse A. Brown / William W. Seeley -- Each Neurodegenerative Syndrome Reflects a Network / Jesse A. Brown / William W. Seeley -- Class-Wide Principles of Network-Based Neurodegeneration / Jesse A. Brown / William W. Seeley -- Parkinsonian Syndromes: Parkinson Disease and Others / Jesse A. Brown / William W. Seeley Note continued: Parkinson Disease: Clinical and Anatomical Features / Jesse A. Brown / William W. Seeley -- Progressive Supranuclear Palsy Syndrome: Clinical Features / Jesse A. Brown / William W. Seeley -- Corticobasal Syndrome: Clinical Features / Jesse A. Brown / William W. Seeley -- Network Architecture of Neurodegenerative Parkinsonian Syndromes / William W. Seeley / Jesse A. Brown -- Network Architecture of Progressive Supranuclear Palsy Syndrome / Jesse A. Brown / William W. Seeley -- Network Architecture of Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Clinicopathological Correlation in Progressive Supranuclear Palsy and Corticobasal Degeneration / Jesse A. Brown / William W. Seeley -- Multiple Proteinopathies Can Cause Progressive Supranuclear Palsy Syndrome and Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Pathological Causes of Progressive Supranuclear Palsy Syndrome / Jesse A. Brown / William W. Seeley Note continued: Pathological Causes of Corticobasal Syndrome / Jesse A. Brown / William W. Seeley -- Progressive Supranuclear Palsy and Corticobasal Degeneration Histopathology Can Cause Multiple Clinical Syndromes / Jesse A. Brown / William W. Seeley -- Genetic Factors in Progressive Supranuclear Palsy and Corticobasal Degeneration / Jesse A. Brown / William W. Seeley -- Rare Monogenic Causes / Jesse A. Brown / William W. Seeley -- Risk Factors / Jesse A. Brown / William W. Seeley -- Genome-Wide Association Studies / Jesse A. Brown / William W. Seeley -- Conclusion / Jesse A. Brown / William W. Seeley -- Acknowledgment / Jesse A. Brown / William W. Seeley -- References / Jesse A. Brown / William W. Seeley -- 19.A New Neuroanatomy of Basal Ganglia Circuitry / Jesse A. Brown / William W. Seeley -- Abbreviations / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian Note continued: Anatomic Overview of Basal Ganglia / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Clinical Basal Ganglia Disorders / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Parkinson Disease / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Huntington Disease / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Classical Basal Ganglia Microanatomy / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Probing Basal Ganglia Circuitry in Animal Models / Carlos Portera-Cailliau / Nader Pouratian / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon -- Recordings in Animals / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian Note continued: Ablation Studies / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Optogenetics / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Animal Studies Reveal Flaws in the Classical Model of Basal Ganglia Circuitry / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Emerging Techniques to Study Basal Ganglia Circuitry in Animals / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Calcium Imaging / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Voltage Sensors / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Optogenetics / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian Note continued: Striatal Interneurons / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Probing Basal Ganglia Circuitry in Humans: Invasive Physiology / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Noninvasive Studies of Basal Ganglia Circuitry in Humans / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- Conclusions / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- References / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian / Nicholas AuYong / Adrienne M. Keener -- 20.Brainstem Circuitry and Emotions / Nicholas AuYong / Adrienne M. Keener / Yvette M. Bordelon / Carlos Portera-Cailliau / Nader Pouratian -- The Structural Organization of the Brainstem / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg Note continued: Reticular Formation / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Chemical Properties of the Reticular Nuclei / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Reticular Formation Modulates Behavior / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Sleep Cycle / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Mood / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Conclusion / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- References / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- 21.Apathy: Frontal and Basal Ganglia Circuits / Panos Theofilas / Helmut Heinsen / Lea T. Grinberg -- Introduction / Pongsatorn Paholpak / Mario F. Mendez -- Definition and Diagnosis of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Clinical Variants, Diagnosis, and Measurement of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Measurement and Rating Scale / Pongsatorn Paholpak / Mario F. Mendez Note continued: Molecular and Neuroanatomical Basis of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Prefrontal Cortex in Primates / Pongsatorn Paholpak / Mario F. Mendez -- Prefrontal Cortex in Humans / Pongsatorn Paholpak / Mario F. Mendez -- Motivation and Reward System: Basal Ganglia Structures and Corticostriatal Loop / Pongsatorn Paholpak / Mario F. Mendez -- Structural and Functional Connectivity in Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Dopamine Regulation in Motivation and Reward System / Pongsatorn Paholpak / Mario F. Mendez -- Apathy in Neuropsychiatric Diseases / Pongsatorn Paholpak / Mario F. Mendez -- Traumatic Brain Injury / Pongsatorn Paholpak / Mario F. Mendez -- Schizophrenia / Pongsatorn Paholpak / Mario F. Mendez -- Stroke / Pongsatorn Paholpak / Mario F. Mendez -- Parkinson Disease / Mario F. Mendez / Pongsatorn Paholpak -- Huntington Disease / Pongsatorn Paholpak / Mario F. Mendez Note continued: Alzheimer Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Frontotemporal Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Genetics Studies of Apathy / Pongsatorn Paholpak / Mario F. Mendez -- Huntington Disease / Pongsatorn Paholpak / Mario F. Mendez -- Parkinson Disease and Parkinsonism / Pongsatorn Paholpak / Mario F. Mendez -- Alzheimer Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Frontotemporal Dementia / Pongsatorn Paholpak / Mario F. Mendez -- Schizophrenia / Pongsatorn Paholpak / Mario F. Mendez -- Summary / Pongsatorn Paholpak / Mario F. Mendez -- References / Pongsatorn Paholpak / Mario F. Mendez -- 22.Emotional Dysfunction in Psychopathology and Neuropathology: Neural and Genetic Pathways / Pongsatorn Paholpak / Mario F. Mendez -- Emotional Dysfunction in Psychopathology and Neuropathology: Neural and Genetic Pathways / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson Note continued: Emotions and Emotional Processes Emotions: Short and Discrete / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Processes / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Reactivity / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Regulation / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Affiliation / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Functioning: Neural Pathways / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Reactivity / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Anterior Cingulate Cortex / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Amygdala / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Hypothalamus / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Brain Stem / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase Note continued: Insula / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Ventrolateral Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dorsolateral Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Anterior Midcingulate Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Inferior Parietal Lobe / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Superior Temporal Sulcus / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dorsomedial Prefrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Ventral Striatum / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Medial Orbitofrontal Cortex / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase Note continued: Septal Area / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Functioning: Genetic Pathways / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Model of the Genetic Pathway / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Reactivity / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Serotonin-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Other Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Dopamine-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Other Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Oxytocin-Related Genes / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase Note continued: Other Genes and Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Neural and Genetic Pathways: Clinical Implications / Virginia E. Sturm / Claudia M. Haase / Robert W. Levenson -- Emotional Dysfunction in Psychopathology and Neuropathology / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Reactivity / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion Regulation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotional Affiliation / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Emotion in Diagnosis / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Psychopathology: Diagnostic and Statistical Manual / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Psychopathology: Research Domain Criteria / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Neuropathology / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase Note continued: Emotion in Treatment / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- References / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- 23.The Anatomy of Delusion / Virginia E. Sturm / Robert W. Levenson / Claudia M. Haase -- Introduction and Definition / Georges Naasan -- Phenomenology and Anatomy / Georges Naasan -- The Two-Factor Hypothesis and the Role of the Right Prefrontal Cortex / Georges Naasan -- Attention Bias and Faulty Assignment of Salience to External Stimuli: The "Aberrant Salience" Model / Georges Naasan -- The Theory of Mind in People With Delusions / Georges Naasan -- Content-Specific Delusions / Georges Naasan -- Paranoid Delusions / Georges Naasan -- The Capgras Delusion / Georges Naasan -- Genetics / Georges Naasan -- References / Georges Naasan -- 24.Beyond Dopamine: The Role of the Serotonergic System and Treatments in Understanding and Treating Visual Hallucinations in Parkinson Disease / Georges Naasan Note continued: Simple Versus Complex Visual Hallucinations / Andrew Evans / Ramon Mocellin / Dennis Velakoulis / Mark Walterfang -- The Visual Pathway and Mechanisms of Disruption Leading to Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Complex Visual Hallucinations: The Role of Lesion Location / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Synucleinopathy and Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- The Origins of Visual Hallucinations in Parkinson Disease / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- The Serotonergic System and Visual Hallucinations / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Anatomy of the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin Note continued: Psilocybin and the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Parkinson Disease and the Serotonergic System / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Pharmacological Interventions for Visual Hallucinations in Parkinson Disease / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- D2 Antagonism / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Serotonin Antagonism / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Summary / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- References / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- 25.Risk Overlap Between Clinical Disorders / Dennis Velakoulis / Mark Walterfang / Andrew Evans / Ramon Mocellin -- Introduction / Patrick F. Sullivan -- Clinical Neuroscience, Neurology, and Psychiatry / Patrick F. Sullivan Notes Includes index Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (ScienceDirect, viewed July 13, 2016) Subject Neuropsychiatry. Neuropsychiatry HEALTH & FITNESS / Diseases / General MEDICAL / Clinical Medicine MEDICAL / Diseases MEDICAL / Evidence-Based Medicine MEDICAL / Internal Medicine Neuropsychiatry Form Electronic book Author Lehner, Thomas (Thomas A.), editor. Miller, Bruce L., 1949- editor. State, Matthew W., editor LC no. 2016931091 ISBN 9780128005309 0128005300

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