| Description |
1 online resource |
| Contents |
Front Cover; Post-Genomic Cardiology; Copyright Page; Contents; Preface; I: Post-Genomic Cardiology; 1 Introduction to the Molecular Biology of the Cell; Nucleic Acids, Genes, Chromatin, and Chromosomes; DNA Transacting Processes: Replication, Transcription, and Repair; DNA replication; Gene expression; Transcription; Pre-mRNA processing; Repair of DNA damage; Genetic Variability Associated with Human Diseases; Cell Cycle; References; 2 Methodologies in the Era of Cardiovascular "Omics"; Introduction; Genomics Approaches: NGS and GWAS; Genome-wide association studies |
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Genome-wide analysis of cardiovascular diseaseTranscriptomics; RNA sequencing; Chromatin immunoprecipitation-based transcriptomics; Transcriptomics of cardiovascular disease; Proteomics and Interactomics; MS-based proteomic technology; Quantitative MS-based proteomics; Proteomic analysis of posttranslational modifications; Interactomics: MS analysis of protein-protein interactions; Metabolomics; Approaches in metabolomic profiling: targeted and untargeted metabolomics; NMR techniques; MS-based technologies; Metabolomics in assessing cardiovascular disease; Cardiac Imaging |
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Super-resolution fluorescence microscopyFluorescent probes and fluorescence resonance energy transfer (FRET); Translational Bioinformatics; Conclusions; Summary; References; Introduction; Cardiac Signaling in Physiological Growth; Receptors; 3 Post-Genomics Cardiovascular Signaling Pathways; Toll-Like receptors; G Proteins; Effectors; Kinases and phosphatases; Ca2+-Mediated Signaling; Integrating responses; Transcription factors and translational control; Translation control; Signaling at the Plasma Membrane; Sarcolemmal KATP channel; Signaling at the Mitochondria |
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Reactive oxygen species generation and signalingNegative effects of ROS; Cell-Cycle signaling, cell proliferation, and apoptosis; Stress, Survival, and Metabolic Signaling; Survival/Growth signals; Stress signals; Metabolic signals; Extracellular signals and matrix; Signaling in Cardiac Development and Aging; Conclusion; Summary; References; II: Pediatric Cardiology in the Post-Genomic Era; Introduction; Overview of Cardiac Morphogenesis; 4 Molecular Determinants of Cardiac Development; Regulatory networks controlling cardiovascular development |
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Major signaling pathways regulating heart developmentTranscription factor circuit regulating cardiac development; MicroRNAs in Cardiovascular Development; Conclusions; Summary; References; Introduction; Etiology of CHD: Interplay of Genetic and Environmental Factors; 5 Molecular Determinants of Congenital Heart Disease; Molecular Mechanisms of CHD; CHD associated with aneuploidy and chromosomal structural abnormalities; CHD caused by single-gene mutations; Syndromic CHDs Caused by Point Mutations; RASopathies; Defects of NOTCH signaling associated with CHD |
| Summary |
In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the "epigenome,? comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap |
| Bibliography |
Includes bibliographical references and index at the end of each chapters |
| Notes |
Online resource; title from PDF title page (ScienceDirect, viewed May 28, 2014) |
| Subject |
Heart -- Diseases -- Molecular aspects.
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Heart -- Diseases -- Genetic aspects.
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Cardiovascular Diseases -- genetics
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Heart -- Diseases -- Genetic aspects.
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Heart -- Diseases -- Molecular aspects.
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| Form |
Electronic book
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| ISBN |
9780124046429 |
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0124046428 |
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