| Description |
1 online resource (xi, 315 pages) : illustrations (some color) |
| Series |
Methods in molecular biology, 1940-6029 ; 1888 |
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Methods in molecular biology (Clifton, N.J.) ; v. 1888. 1064-3745
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| Contents |
1. Cellular thermal shift assay (CETSA)- Molina 2. Thermal proteome profiling (TPP) - Savitski 3. Generation and Investigation of drug-related resistant mutations; DrugTargetSeq - Tarun Kapoor 4. BRET for target engagement - Robers/Stoddard 5. Raman imaging for small molecule visualization in cells- M. Sodeoka 6. Target prediction for small molecules using Proteobase - Osada 7. Target prediction for small molecules using Morphobase- Osada 8. Predictive chemogenomics based on gene expression profiles - S.Schreiber 9. Genome-wide mapping of ligand interactions (Chem-seq)- R.A: Young 10. Cheminformatics to assess drug-target networks -(more than one chapter possible) - G. Schneider (and others) 11. Yeast-based methods for target identification - Dominic Hoepfner 12. A genome scale overexpression screen to reveal drug activity in human cells -- Guri Giaever and Corey Nislow 13. High-content phenotypic profiling for compound characterization (ORACL) -- S:J Altschuler, and L.F. Wu 14. Connectivity map / Drug target prioritization by perturbed gene expression and network information. Lamb and Golubb 15. Activity-based proteome profiling (Proteome-wide covalent ligand discovery in native biological systems) - Cravatt 16. Multiplex Cytological Profiling Assay to Measure Diverse Cellular States (Cell painting) Alykhan F. Shamji 17. Multidimensional Drug Profiling By Automated Microscopy -- N.O. Carragher 18. ProTacs: New approaches to protein degradation - C. Crews 19. Bioluminescent sensors /Modulating protein activity using tethered ligands -Kai Johnsson 20. Spatially resolved proteomic mapping in living cells -- Alice Ting 21. Small molecules approaches for stem cell biology - Sheng Ding, Stephen J. Haggarty, O. Brüstle or Hongkui Deng 22. Zebrafish for compound activity screening - R.T. Peterson 23. Employment of Drosophila (cells) to detect inhibitors of lipid droplet formation - M. Beller; Matt Boxer |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed December 12, 2018) |
| Subject |
Systems biology -- Laboratory manuals
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Systems biology.
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Cytology -- Technique.
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Systems Biology
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Cytological Techniques
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Molecular biology.
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Science -- Life Sciences -- Anatomy & Physiology.
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Cytology -- Technique
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Systems biology
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| Genre/Form |
Laboratory manuals
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Laboratory manuals.
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Manuels de laboratoire.
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| Form |
Electronic book
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| Author |
Waldmann, H. (Herbert), editor.
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Ziegler, Slava, editor
|
| ISBN |
9781493988914 |
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1493988913 |
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