| Description |
1 online resource (ix, 266 pages) : illustrations (some color) |
| Series |
Recent results in cancer research, 0080-0015 ; volume 207 |
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Recent results in cancer research ; v. 207.
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| Contents |
Contributors; Description and Purpose of the Work; 1 The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells; Abstract; 1 Glucose Metabolism in Cancer Cells; 2 Lipid Metabolism in Cancer Cells; 3 The Cost of Increased Lipid Biosynthesis in Cancer Cells; 4 Lipid Uptake and Remodelling in Cancer; 5 Concluding Remarks; References; 2 Lactate-An Integrative Mirror of Cancer Metabolism; Abstract; 1 Introduction; 2 Metabolic Reprogramming in Malignant Tumors; 3 The imBI Technique; 4 Representativeness of One Versus Multiple Biopsies |
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5 Metabolic Asservation in Liquid Nitrogen6 Metabolic Imaging with ImBI in Rectum Cancer; 7 Conclusions; Acknowledgments; References; 3 Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer; Abstract; 1 Introduction; 2 Signaling Through the PI3K-Akt-mTOR Pathway; 2.1 PI3K-Akt Pathway Activation; 2.2 Downstream Effectors; 2.2.1 Post-translational Modulation; 2.2.2 Transcriptional Output; FoxO; c-Myc; HIFs; SREBPs; 3 The PI3K-Akt-mTOR Pathway Regulates Glucose Metabolism and the Warburg Effect; 3.1 Glucose Uptake; 3.1.1 Glucose Uptake in the Clinic; 3.2 Regulation of Glycolytic Enzymes |
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4 Beyond Aerobic Glycolysis: Coordination with Anabolic Metabolism4.1 Pentose Phosphate Pathway; 4.2 Nucleotide Biosynthesis; 4.3 Lipid Synthesis; 4.4 Glutamine Metabolism; 5 Concluding Remarks; References; 4 MYC, Metabolic Synthetic Lethality, and Cancer; Abstract; 1 Background; 2 Regulation of MYC and Its Function; 3 MYC Target Genes and Metabolism; 4 MYC, Protein Synthesis, and Ribosomal Biogenesis; 5 MYC Metabolic Synthetic Lethal Interactions and Therapy; 6 Concluding Remarks; References; 5 The Role of pH Regulation in Cancer Progression; Abstract; 1 Introduction |
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1.1 Measurements of Intracellular and Extracellular Tumour pH2 Why Are Tumours Acidic?; 2.1 pH Sensing; 2.2 Mechanisms of pH Regulation; 3 Lactate Acid Secretion (Monocarboxylate Transporters 1-4); 4 Sodium Hydrogen Ion Exchangers (NHE); 5 Vacuolar-Type H+ ATPase; 6 Extracellular Membrane-tethered Carbonic Anhydrases (CAIX/CAXII); 7 Bicarbonate Transporters; 8 Metabolons; 8.1 pH and Cell Phenotype; 8.1.1 Proliferation and Growth; 9 The Effect of pH on Migration and Metastasis; 10 The Expression of PH Regulators and Metastasis |
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11 Functional Studies of pH Regulators and Their Effects on Migration and Metastasis12 Therapeutic Considerations; 12.1 The Effects of pH on Chemotherapy and Radiotherapy; 13 pH Modulators as Therapeutic Targets; 14 Conclusion; Acknowledgments; References; 6 Metabolic Features of Cancer Treatment Resistance; Abstract; 1 Overview of Tumor Resistance: Old Concepts and New Foes; 2 Metabolism of Treatment-Resistant Cells; 3 Therapeutic Implications; 4 Autophagy, Mitochondrial Respiration, and Tumor Stem Cells: The Ultimate Theory of Tumor Resistance; Acknowledgments; References |
| Summary |
This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy |
| Notes |
Online resource; title from PDF title page (SpringerLink, viewed August 31, 2016) |
| Subject |
Cancer -- Molecular aspects.
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Metabolism.
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Neoplasms -- metabolism
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Metabolism
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metabolism (biological concept)
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Immunology.
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Biochemistry.
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Cellular biology (cytology)
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Oncology.
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Cancer -- Molecular aspects
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Metabolism
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| Form |
Electronic book
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| Author |
Cramer, Thorsten, editor
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Schmitt, Clemens, editor
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| ISBN |
9783319421186 |
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3319421182 |
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