| Description |
1 online resource (241 pages) |
| Contents |
Cover; Half Title; Title Page; Copyright Page; Preface; Acknowledgments; Table of Contents; 1 Primer on Molecular Genetics; 1.1 Genetic Variation; 1.2 The Human Genome; 1.3 Consequences of Genetic Variation; 1.4 Genetic Nomenclature; 2 Primer on Medical Genetics; 2.1 The Location of Disease-causing Mutations; 2.2 Single-Gene, Oligogenic, and Multigenic Disorders; 2.3 Copy Number of Mutant Genes; 2.4 Inherited Mutations; 3 Primer on Population Genetics; 3.1 Hardy-Weinberg Equilibrium; 3.2 Linkage Disequilibrium; 3.3 Population Substructure; 3.4 Signatures of Natural Selection |
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4 Epidemiologic Principles and Genetic Association Studies4.1 Types of Epidemiologic Association Studies; 4.2 Chance, Bias, Confounding, and Effect Modification; 4.3 Causality and Statistical Association; 5 Environmental Epidemiology in the Context of Genetic Epidemiology; 5.1 Studying Environmental Effects; 5.2 Examining and Estimating Environmental Effects; 5.3 The Environment and Gene Activity; 5.4 Gene and Environment Interactions, Personalized Prevention, and Treatment; 6 Elementary Statistical Concepts; 6.1 Statistical Power and Statistical Significance; 6.2 Study Design and Errors |
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6.3 Data Analysis7 Genotyping Methods and Errors; 7.1 Genotyping Principles; 7.2 Genotyping and PCR; 7.3 Choice of Genotyping Method; 7.4 Sources of DNA for Genotyping; 7.5 Genotyping Errors; 7.6 Imputing Genotypes; 8 Candidate Gene Studies and Genome-Wide Association Studies; 8.1 Candidate Genes; 8.2 Candidate Variants; 8.3 Candidate Gene Studies in the GWAS age; 8.4 Advantages and Disadvantages of a GWAS; 9 Statistical Analysis of Genetic Association Study Results; 9.1 Standard Genetic Association Analysis; 9.2 GWAS Analysis |
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10 Bioinformatics for the Interpretation of Genetic Association Study Results10.1 Bioinformatics for Testing SNP Associations; 10.2 Functional Annotation of SNPs; 10.3 Analyzing Functionally Altered Genes; 11 Genetic Risk Profiling and Medical Applications of Genetic Associations; 11.1 Genetic Risk Profiling and Genetic Markers; 11.2 Assessing Clinical Utility; 11.3 Disease Biology and Pharmacogenomics; Glossary; Index |
| Notes |
Print version record |
| Form |
Electronic book
|
| ISBN |
9781351806435 |
|
1351806432 |
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