| Description |
1 online resource |
| Contents |
Front Cover; BIOMARKERS IN TOXICOLOGY; BIOMARKERS IN TOXICOLOGY; Copyright; Dedication; Contents; Contributors; Foreword; I -- TOXICITY TESTING MODELS AND BIOMARKERS; 1 -- Introduction; References; 2 Rodent Models for Toxicity Testing and Biomarkers; INTRODUCTION; THE RAT; Use in Toxicological Research; Characteristics; Strain Differences; Normal Physiological Values; STUDY DESIGNS; ROUTES OF TEST ARTICLE ADMINISTRATION; Oral Routes; Dietary Versus Gavage Methods; Dietary Method; Gavage Method; Test Article Preparation; Equipment; Technique; Neonatal Administration; Capsule; Water |
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Intravenous RouteLateral Tail Vein; Bolus Injection; Tail Vein Infusions; Jugular Vein; Bolus Injection; Infusion; Saphenous, Lateral Marginal, and Metatarsal Veins; Dorsal Penis Vein; Sublingual Vein; Intraperitoneal Route; Intramuscular Route; Subcutaneous Route; Topical Route; Rectal Route; Intranasal Route; Inhalation Route; Intratracheal Administration; REGIMEN; END POINT MEASUREMENT TECHNIQUES; Observations and Physical Examinations; Neurobehavioral Examination; Functional Observational Battery; Locomotor Activity; Cardiovascular Parameters; Electrocardiography; Recording Methods |
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RestraintPosition; Tethered; Leads; Telemetry; ECG Waveform; Heart Rate; Blood Pressure; Indirect Measurement; Tail Cuff Method; Hindpaw Method; Direct Measurement; Blood Collection Techniques; Retro-Orbital Plexus; Tail; Tail Clip; Venipuncture; Arterial Puncture; Cardiac Puncture; Abdominal Aorta and Vena Cava; Jugular Vein; Proximal Saphenous and Metatarsal Vein; Proximal Saphenous Vein; Metatarsal Vein; Sublingual Vein; Decapitation; Cannulation; Jugular Vein; Inferior Vena Cava; Abdominal Aorta; Subcutaneous Ports; Urine Collection; Necropsy; SUMMARY; The Mouse |
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Use in Toxicological ResearchNormal Physiological Values; Species Differences; Strain Differences; STUDY DESIGNS; Acute Toxicity Studies; Short-Term Toxicity Studies; Chronic Toxicity Studies (26weeks-2years); Carcinogenicity Studies (18-24months); Teratology Studies; Segment II Teratology Studies; Genetic Toxicity Studies; Mouse Micronucleus Assay; Heritable Translocation Assay; Microbial Host-Mediated Assay; Special Studies; Mouse Ear Swelling Test; Dermal Carcinogenicity (Skin Painting) Study; ROUTES OF TEST SUBSTANCE ADMINISTRATION; Oral Administration; Gavage; Description of Technique |
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Dietary AdmixturesDescription of Technique; Drinking Water; Description of Technique; Intravenous Injection; Description of Technique; Intraperitoneal Injection; Description of Technique; Intramuscular Injection; Description of Technique; Subcutaneous Injection; Description of Technique; Intradermal Injection; Description of Technique; Topical Administration; Description of Technique; Inhalation; Chamber (Whole Body); Head/Nose Exposure (Head Only/Nose Only); END POINT DATA COLLECTION; Clinical Observations and Physical Examinations; Clinical Laboratory Evaluations; Postmortem Procedures |
| Summary |
Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed Feburary 19, 2019) |
| Subject |
Biochemical markers.
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Toxicology.
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Biomarkers
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Environmental Exposure
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Environmental Pollutants -- toxicity
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Hazardous Substances -- toxicity
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Toxicology
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toxicology.
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MEDICAL -- Pharmacology.
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Biochemical markers
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Toxicology
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| Form |
Electronic book
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| Author |
Gupta, Ramesh C. (Ramesh Chandra), 1949- editor.
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| ISBN |
9780128146569 |
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0128146567 |
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9780128146552 |
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0128146559 |
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