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Title Cell and molecular biology of ovarian cancer : updates, insights and new frontiers / Heide Schatten, editor
Published Cham, Switzerland : Springer, [2024]
©2024

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Description 1 online resource (ix, 128 pages) : illustrations (chiefly color)
Series Advances in experimental medicine and biology ; vvolume 1452
Advances in experimental medicine and biology ; v. 1452.
Contents Intro -- Preface -- Contents -- 1: Microtubule-Targeting Agents: Disruption of the Cellular Cytoskeleton as a Backbone of Ovarian Cancer Therapy -- 1.1 Microtubules -- 1.1.1 Formation and Features -- 1.1.2 Role in Cellular Function -- 1.2 NCCN-Approved Agents for Use in Ovarian Cancer -- 1.3 Microtubule-Stabilizing Agents -- 1.3.1 Paclitaxel -- 1.3.2 Nab-paclitaxel -- 1.3.3 Docetaxel -- 1.3.4 Ixabepilone -- 1.4 Microtubule-Destabilizing Agents -- 1.4.1 Vincristine -- 1.4.1.1 Vinblastine -- 1.4.2 Vinorelbine -- 1.5 Mechanisms of Resistance -- References
2: Tubulin Complexity in Cancer and Metastasis -- 2.1 Tubulin Complexity -- 2.2 Microtubule-Associated Proteins (MAPs) -- 2.3 Tubulin Posttranslational Modifications (PTMs) -- 2.4 Microtentacles -- References -- 3: The Impact of Centrosome Pathologies on Ovarian Cancer Development and Progression with a Focus on Centrosomes as Therapeutic Target -- 3.1 Introduction -- 3.2 Structure, Composition, and Function of Centrosomes and Abnormalities/Dysregulation in Ovarian Cancer -- 3.3 Centrosome Regulation in Normal Cell Cycles
3.4 Centrosome Dysregulation, Abnormalities in Ovarian Cancer, and New Research to Correct Centrosome Abnormalities -- 3.4.1 Centrosome Clustering -- 3.5 The Role of Primary Cilia in Ovarian Cancer -- 3.6 Centrosomes as Target for Ovarian Cancer Therapy -- 3.7 Conclusion and Future Directions -- References -- 4: Drug-Resistant Epithelial Ovarian Cancer: Current and Future Perspectives -- 4.1 Introduction to Epithelial Ovarian Cancer and Its Subtypes -- 4.1.1 Type I Neoplasms -- 4.1.1.1 Low-Grade Serous Ovarian Cancer (LGSOC) Subtype -- 4.1.1.2 Sero-mucinous Subtype
4.1.1.3 Mucinous Ovarian Carcinomas (MOC) -- 4.1.1.4 Endometrioid Ovarian Carcinomas (EEOC) -- 4.1.1.5 Clear Cell Ovarian Carcinomas (CCOC) -- 4.1.1.6 Brenner Tumours -- 4.1.2 Type II Neoplasms -- 4.1.2.1 High-Grade Serous Ovarian Cancer (HGSOC) -- 4.1.2.2 High Grade EEOC -- 4.1.2.3 Undifferentiated Carcinoma -- 4.2 Current Diagnostic Strategies -- 4.3 Current Treatment Modalities -- 4.3.1 Targeted Therapy -- 4.4 Resistance, a Major Limitation Against Currently Available Therapeutics -- 4.5 Elucidating Drug Resistance Mechanisms: Understanding the Molecular Players
4.5.1 Decreased Intracellular Drug Accumulation and Increased Drug Export -- 4.5.1.1 Influx Transporters -- 4.5.1.2 Efflux Transporters -- 4.5.2 Increased Drug Inactivation -- 4.5.2.1 CYP System -- 4.5.2.2 Glutathione S-Transferase (GST) -- 4.5.2.3 Uridine Diphospho-glucuronosyltransferase (UGT) Superfamily -- 4.5.3 Resistance to PARP Inhibitors and HR Pathways -- 4.5.4 Deregulated Autophagy -- 4.5.5 Altered Metabolism -- 4.5.5.1 Glucose Metabolism -- 4.5.5.2 Fatty Acid Metabolism -- 4.5.5.3 Altered Glutamine Metabolism -- 4.5.6 Evasion of Apoptosis -- 4.5.7 Cancer Stem Cells -- 4.5.8 Role of miRNAs and lncRNA
Summary The first of two companion books addressed the biology and clinical aspects of ovarian cancer. The companion title, Ovarian Cancer: Molecular & Diagnostic Imaging and Treatment Strategies, discussed both classic and the most recent imaging approaches for detection, early diagnosis and treatment of ovarian cancer. This volume, Cell & Molecular Biology of Ovarian Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to ovarian cancer. Taken together, these two volumes form one comprehensive and invaluable contribution to the literature
Notes Description based on online resource; title from digital title page (viewed on June 21, 2024)
Subject Ovaries -- Cancer -- Molecular aspects
Ovaries -- Cancer -- Cytopathology
Ovaries -- Cancer -- Genetic aspects
Form Electronic book
Author Schatten, Heide, editor
ISBN 9783031583117
3031583116