| Description |
1 online resource (450 p.) |
| Contents |
880-01 Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- Dedication -- HCV-Host Interactions: A Plethora of Genes and their Intricate Interplay Part 1: Virus Specific Factors -- INTRODUCTION -- Hepatitis C Virus Taxonomy -- HCV: Route of Transmission -- HCV Genome Organization -- HCV MOLECULAR BIOLOGY -- HCV MOLECULAR VIROLOGY -- HEPATITIS C PROTEINS IN MOLECULAR PATHOGENESIS OF INFECTION -- 5' Untranslated Region (5' UTR) -- HCV Antigen (Core -- C) Protein |
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880-01/(S ANGPTLs Linked to HCV Induced Hepatic Fibrosis and Tumorigenesis -- ANGPTL Expression in Various Stages of Hepatic Fibrosis -- ANGPTL-3/4 Interacts With TGF-β to Promote Hepatic Fibrosis and Cirrhosis -- VITAMIN D AND HCV INDUCED HEPATOCELLULAR CARCINOMA -- INTRACELLULAR SIGNALING MODULATION IN HEPATITIS C INFECTION -- TLR Activation and their Implications in HCV Molecular Pathogenesis -- TNF/TNF Receptor Activation in CHC Patients -- FAS/FASL Activation in CHC Patients -- NF-ƙB Cell Signaling and HCV Progression -- CONCLUSIONS -- REFERENCES |
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HCV Core Protein Morphology -- HCV Core Protein and Hepatic Steatosis -- HCV Core Protein and Hepatocarcinogenesis -- HCV Core Protein and Insulin Resistance (IR) -- HCV Envelope Glycoproteins (E1 and E2) -- HCV E1 and E2 Morphology -- HVR1 of E2 Glycoprotein Modulates the Immune System -- HCV NONSTRUCTURAL PROTEINS AND THEIR ROLE IN HEPATITIS C PATHOGENESIS -- NS2 Metalloprotease -- NS3/4A Serine Protease/Helicase -- NS4B -- NS5A: An Interferon Resistance Protein -- NS5B: RNA Dependent RNA Polymerase (RdRp) -- 3' UTR -- CONCLUSIONS -- REFERENCES |
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HCV-Host Interactions: Interplay Part 2: Host Related Determinants and Intracellular Signaling -- INTRODUCTION -- CERTAIN HOST SPECIFIC FACTORS ARE VITAL FOR HCV REPLICATION -- PPP2R5D (Protein Phosphatase 2 Regulatory Subunit B'Delta) Protein -- Micro RNAs (miRNA) -- miR-122: A Key Regulator of HCV Replication in Hepatocytes -- miR-135a Drives Chronic Hepatitis C Infection to HCC -- Cytokines Gene Polymorphisms in Chronic Hepatitis C Patients -- The Importance of Cytokines against Viral Infections -- Cytokine Gene Polymorphism for IL-10 -- Cytokine Gene Polymorphism for IL-13 |
| Summary |
The burden of hepatitis C virus (HCV) infection on the public health care system continues to remain significant despite the remarkable progress made in HCV therapeutics in the recent past. There are now almost a dozen oral interferon-free direct-acting antivirals available for the treatment of hepatitis C virus infection. Despite advances in the treatment of HCV, therapeutic gaps remain that are yet to be fully explored. Researchers and scientists still striv |
| Notes |
Description based upon print version of record |
|
Immune Responses and Immunopathology of Acute and Chronic Hepatitis C Virus Infection |
| Subject |
Hepatitis C virus -- Treatment
|
| Form |
Electronic book
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| Author |
Jabeen, Qaiser
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| ISBN |
9815123432 |
|
9789815123432 |
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