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Book Cover

Title Targeted radionuclide tumor therapy : biological aspects / Torgny Stigbrand, Jörgen Carlsson, Gregory P. Adams, editors
Published [Dordrecht] : Springer, ©2008


Description 1 online resource (xiii, 402 pages) : illustrations (some color)
Contents Introduction to Radionuclide Therapy / Jörgen Carlsson, Torgny Stigbrand, and Gregory P. Adams -- Therapeutically Used Targeted Antigens in Radioimmunotherapy / Torgny Stigbrand, David Eriksson, Katrine Riklund, and Lennart Johansson -- EGFR-Family Expression and Implications for Targeted Radionuclide Therapy / Jörgen Carlsson -- Targeting Tumours with Radiolabeled Antibodies / Torgny Stigbrand, David Eriksson, Katrine Riklund, and Lennart Johansson -- Antibody Fragments Produced by Recombinant and Proteolytic Methods / Gregory P. Adams -- Novel Alternative Scaffolds and Their Potential Use for Tumor Targeted Radionuclide Therapy / Fredrik Y. Frejd -- Peptides for Radionuclide Therapy / Marion de Jong, Suzanne M. Verwijnen, Monique de Visser, Dik J. Kwekkeboom, Roelf Valkema, and Eric P. Krenning -- Choice of Radionuclides and Radiolabelling Techniques / Vladimir Tolmachev -- High-LET-Emitting Radionuclides for Cancer Therapy / George Sgouros -- Targeted High-LET Therapy of Bone Metastases / Øyvind S. Bruland, Dahle Jostein, Dag Rune Olsen, and Roy H. Larsen -- The Auger Effect in Molecular Targeting Therapy / Hans Lundqvist, Bo Stenerlöw, and Lars Gedda -- Radiation Induced Cell Deaths / David Eriksson, Katrine Riklund, Lennart Johansson, and Torgny Stigbrand -- Radiation Induced DNA-Damage/Repair and Associated Signaling Pathways / Bo Stenerlöw, Lina Ekerljung, Jörgen Carlsson, and Johan Lennartsson -- Radiation Induced DNA Damage Checkpoints / David Eriksson, Katrine Riklund, Lennart Johansson, and Torgny Stigbrand -- Cancer Stem Cells and Radiation / David Eriksson, Katrine Riklund, Lennart Johansson, and Torgny Stigbrand -- Effects of Low Dose-Rate Radiation on Cellular Survival / Jörgen Carlsson -- Bystander Effects and Radionuclide Therapy / Kevin M. Prise -- Enhancing the Efficiency of Targeted Radionuclide Therapy / Gregory P. Adams -- Low Dose Hyper-Radiosensitivity: A Historical Perspective / Brian Marples, Sarah A. Krueger, Spencer J. Collis, and Michael C. Joiner -- Clinical Radionuclide Therapy / Andrew M. Scott and Sze-Ting Lee -- Developmental Trends in Targeted Radionuclide Therapy: Biological Aspects / Torgny Stigbrand, Jörgen Carlsson, and Gregory P. Adams
Summary The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. The expanding array of new targeting molecules (recombinant antibodies or peptides) may increase the therapeutic efficacy. The title of this book "Targeted Radionuclide Tumor Therapy a" Biological aspects" was selected to reinforce the concept that a major focus was devoted to understanding the biological effects of targeting and radiation. Furthermore, our rapidly expanding knowledge of low dose-rate effe
Bibliography Includes bibliographical references and index
Notes English
Print version record
Subject Tumors -- Treatment
Nuclear medicine.
Neoplasms -- therapy
Radioisotopes -- therapeutic use
Antibodies -- therapeutic use
Nuclear Medicine
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Nuclear medicine.
Tumors -- Treatment.
Genre/Form Electronic resource
Form Electronic book
Author Stigbrand, Torgny.
Carlsson, Jörgen, 1960-
Adams, Gregory P
ISBN 9781402086960