| Description |
1 online resource (276 pages) |
| Series |
Gene and Cell Therapy Ser |
|
Gene and Cell Therapy Ser
|
| Contents |
Cover; Half Title; Title Page; Copyright Page; Contents; Series Preface; Preface; Editors; Contributors; Chapter 1: Intervertebral Disc Degeneration in Clinics; 1.1 Introduction; 1.2 Importance of Disc Degeneration and LBP; 1.3 Clinical Manifestations of Disc Degeneration; 1.4 Intervertebral Disc Degeneration in Imaging Studies; 1.5 Relation Between Disc Degeneration and Pain; 1.6 Prognosis; 1.7 Therapeutic Challenges for Discogenic LBP; 1.7.1 Conservative Treatment; 1.7.2 Percutaneous Techniques; 1.7.3 Operative Treatment; 1.7.4 Regenerative Techniques |
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1.8 Therapeutic Challenges for Sciatica1.9 Final Remarks; References; Chapter 2: Animal Models and Imaging of Intervertebral Disc Degeneration; 2.1 Introduction; 2.2 In Vivo Models of DDD; 2.3 Characteristics of the IVD Among Species; 2.3.1 Anatomy of the IVD: Comparison of Various Animal Models; 2.3.2 Cellular Population of the IVD; 2.3.3 Biomechanics of the IVD; 2.4 DDD Induction Technique; 2.4.1 Animal Models of Spontaneously Occurring DDD; 2.4.1.1 Degeneration Related to Aging; 2.4.1.2 Inherited Lesions; 2.4.1.3 Genetic Models; 2.4.2 Experimentally Induced Disc Disease |
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2.4.2.1 Mechanical Models2.4.2.1.1 Bipedalism; 2.4.2.1.2 Forceful Bending; 2.4.2.1.3 Compression; 2.4.2.1.4 Instability (Fusion and Facetectomy); 2.4.2.2 Structural Models; 2.4.2.2.1 Physical Models; 2.4.2.2.2 Enzymatic Models: Chemonucleolysis; 2.4.2.2.3 Endplate Injury; 2.5 Surgical Approach to the IVD; 2.6 Potential Applications of the Different Models; 2.7 Imaging of IVD Degeneration and Perspectives; 2.7.1 Physiopathology Context; 2.7.2 X-Ray Imaging; 2.7.3 Nuclear Medicine; 2.7.4 Magnetic Resonance Imaging; 2.8 New Developments in MRI; 2.9 Conclusion; References |
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Chapter 3: Intervertebral Disc Whole Organ Cultures3.1 Introduction; 3.2 Changes in Human IVD Degeneration; 3.2.1 Proteoglycans; 3.2.2 Collagen; 3.2.3 Cytokines; 3.2.4 Enzymes; 3.2.5 Mechanobiology; 3.3 Established Whole-Organ Culture Models; 3.4 Monitoring Degenerative Changes in Ex Vivo IVD Organ Culture; 3.4.1 Proteoglycan Analysis; 3.4.2 Collagen Analysis; 3.4.3 Cytokine Analysis; 3.4.4 Enzyme Analysis; 3.4.5 Cell Viability; 3.4.6 Macroscopic Evaluation; 3.4.7 Recent Developments in Mechano-Biological Assessment of IVDs; 3.5 Conclusion; References |
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Chapter 4: Adult Stem Cells for Intervertebral Disc Repair4.1 Intervertebral Disc and Its Degeneration; 4.2 Committed Cell-Based Therapies; 4.3 Adult Stem Cells; 4.4 Adult Stem Cell-Based Therapies; 4.5 Clinical Studies; 4.6 Challenges for Adult Stem Cell Therapies for IVD Repair; 4.6.1 Do Transplanted Adult Stem Cells Survive in the IVD?; 4.6.2 What Is the Mechanism of Action of Transplanted Adult Stem Cells?; 4.6.3 Should the Adult Stem Cells Be Predifferentiated?; 4.6.4 What Is the Best Adult Stem Cell Source?; 4.6.5 What Is the Optimal Dose of Adult Stem Cells? |
| Notes |
4.6.6 How Should Adult Stem Cells Be Delivered? |
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Print version record |
| Form |
Electronic book
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| Author |
Barbosa, Mario Adolfo
|
| ISBN |
9781351030168 |
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1351030167 |
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