| Description |
1 online resource (182 pages) |
| Contents |
Intro; Preface; Contents; 1: Chance and Causality in Ageing and Longevity; 1.1 Introduction; 1.2 Role of Chance in Ageing and Longevity; 1.3 Socio-economic Development and Life Expectancy: Causal Role of Education; 1.4 Role of Sex and Gender in Ageing and Longevity; 1.5 Inflamm-ageing and Oxidative Stress as Causal Factors of Ageing; 1.6 The (De)regulation of Nutrient-Sensing Pathways in Ageing and Longevity; 1.7 Physical Activity and Longevity; 1.8 Psychological Stress and Longevity; 1.9 Conclusion; References; 2: Phenotypic Aspects of Longevity; 2.1 Introduction |
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2.2 Haematochemical Values2.3 Age-Related Diseases in Centenarians; 2.4 Oxidative Stress and Inflammation; 2.5 Psychological and Cognitive Function; 2.6 Body Composition; 2.7 Conclusion; References; 3: Centenarian Offspring as a Model of Successful Ageing; 3.1 Introduction; 3.2 Hereditary and Modifiable Factors Influencing Longevity in Centenarian Offspring; 3.3 Phenotypic Features of Centenarian Offspring; 3.4 Age-Related Disease Risk Profile in Centenarian Offspring; 3.4.1 Inflammatory Status; 3.4.2 CVD Risk Profile |
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3.5 Other Biomarkers of Successful Ageing in Centenarian Offspring3.6 Immunophenotype of Centenarian Offspring and Successful Immunosenescence; 3.7 Conclusion; References; 4: Individual Longevity Versus Population Longevity; 4.1 Introduction; 4.2 Individual Longevity; 4.3 The Validation of Age; 4.4 Some Examples of (In)validation of the Age of Alleged Supercentenarians (Extracted from [8]); 4.5 About the Age of the Oldest Person on Earth; 4.6 Population Longevity; 4.7 The Blue Zones; 4.8 Conclusion; References; 5: Dietary Inflammatory Index in Ageing and Longevity |
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5.1 Introduction5.2 The Dietary Inflammatory Index; 5.3 DII and Metabolic Disorders; 5.4 DII and Cardiovascular Diseases; 5.5 DII and Cancer; 5.6 DII and Longevity; 5.7 Conclusion; References; 6: Genetic Signatures of Centenarians; 6.1 Exceptional Longevity Is an Inherited Phenotype; 6.2 Case-Control Candidate Gene Approach; 6.3 Case-Control Studies Without A Priori Hypothesis (Non-hypothesis Driven); 6.4 Meta-Analysis of GWAS; 6.5 Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS); 6.6 Conclusion; References; 7: Epigenetics and Ageing; 7.1 DNA Methylation |
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7.2 Histone Modifications7.3 Non-coding RNAs; 7.4 Epigenetic Modifications in Ageing; 7.4.1 DNA Methylation and Ageing; 7.4.2 Histone Modifications and Ageing; 7.4.3 miRNAs and Ageing; 7.5 Epigenetic Modifications in Age-Related Diseases; References; 8: Lifestyle Choices, Psychological Stress and Their Impact on Ageing: The Role of Telomeres; 8.1 Introduction; 8.2 Associations Between Lifestyle Choices and Telomere Length Biology; 8.2.1 Physical Activity; 8.2.2 Diet; 8.2.2.1 Food Compounds; 8.2.2.2 Mediterranean Diet; 8.2.3 Psychological Stress; 8.2.3.1 Phobic Anxiety |
| Summary |
This state-of-the-art review on longevity focuses on centenarians, studied as a model of positive biology. The extraordinary rise in the elderly population in developed countries underscores the importance of studies on ageing and longevity in order to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies. Centenarians have reached the extreme limits of human life span. Those in relatively good health, who are able to perform their routine daily tasks, are the best examples of extreme longevity, representing selected individuals in which the appearance of major age-related diseases - including cancer and cardiovascular diseases - has been consistently delayed or avoided. The relationship between causality and chance is an open discussion topic in many disciplines. In particular, ageing, the related diseases, and longevity are difficult to define as a consequence of causality, chance or both. Discussing the relevance of these different factors in the attainment of longevity, the book gathers contributions on genetic, epigenetic and phenotypic aspects of centenarians. The "positive biology" approach is applied to clarify the causes of positive phenotypes, as well as to explain the biological mechanisms of health and well-being with the aim of preventing and/or reducing frailty and disability in the elderly. -- Provided by publisher |
| Notes |
8.2.3.2 Psychological Stress and Early Adversity |
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Print version record |
| Subject |
Centenarians -- Health and hygiene
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Centenarians -- Medical care
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Human beings.
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Centenarians
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Longevity
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Aged
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Humans
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Homo sapiens (species)
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Aging -- Research
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Geriatrics
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Human genetics
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Medicine
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Pathology
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| Form |
Electronic book
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| Author |
Caruso, Calogero.
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| ISBN |
3030207625 |
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9783030207625 |
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9783030207632 |
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3030207633 |
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9783030207649 |
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3030207641 |
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