| Description |
1 online resource (808 p.) |
| Contents |
Intro -- Mitochondrial Physiology and Vegetal Molecules: Therapeutic Potential of Natural Compounds on Mitochondrial Health -- Copyright -- Dedication -- Contents -- Contributors -- About the editor -- Preface -- Acknowledgments -- Part I Overview of mitochondrial physiology -- Chapter 1 Mitochondria: Ultrastructure, dynamics, biogenesis, and main functions -- 1 Introduction -- 2 Mitochondrial ultrastructure -- 3 Mitochondrial morphology, distribution, and dynamics -- 4 Biogenesis, maintenance, and quality control -- 4.1 Mitochondrial protein import and sorting -- 4.1.1 TOM (translocase of outer mitochondrial membrane) complex -- 4.1.2 TIM23 presequence translocase -- 4.1.3 The carrier pathway into the inner membrane -- 4.1.4 The intermembrane space, mitochondrial import, and assembly machinery (MIA) -- 4.1.5 Import of mitochondrial outer membrane proteins -- 4.2 Mitochondrial protein homeostasis: biogenesis, regulation, and quality control -- 4.2.1 Protein trafficking, processing, and activation: Processing peptidases -- 4.2.2 Chaperones involved in the correct folding of proteins within mitochondria -- 4.2.3 Additional factors required for the biosynthesis of OXPHOS complexes -- 4.2.4 Protein quality control -- 5 Mitochondrial functions -- 5.1 Mitochondrial oxidative phosphorylations and mitochondrial carriers -- 5.2 Thermokinetic control and yield of oxidative phosphorylations -- 5.3 Mitochondrial ROS and their detoxification -- 5.3.1 Dioxygen: A poison for life -- 5.3.2 ROS production by the respiratory chain -- 5.3.3 Control of ROS production flux by mitochondria -- 5.3.4 ROS enzymatic detoxification -- 6 Concluding remarks -- Acknowledgments -- References -- Chapter 2 Mitochondrial biogenesis and mitophagy -- 1 Introduction -- 1.1 Mitochondria in cellular and systematic conditioning for organismal homeostasis |
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1.2 Mitochondrial function declines during aging and contributes to many hallmarks of aging -- 2 Mitochondrial biogenesis -- 2.1 Mitochondrial genome -- 2.2 Nuclear regulation -- 2.2.1 Nuclear respiratory factors and nuclear factor erythroid 2-related factor 2 -- 2.2.2 PGC-1 family proteins -- 2.3 Mitochondrial protein import machineries -- 2.4 Mitohormesis: Mild mitochondrial stress couples mitochondrial biogenesis to mitophagy for mitochondrial maintenance -- 3 Molecular pathways for mitophagy -- 3.1 Basal mitophagy -- 3.2 Stress-induced mitophagy -- 3.2.1 Mitochondrial uncouplers: PINK1-Parkin mitophagy -- PINK1 stabilization and activation on the mitochondrial surface -- PINK1-mediated Parkin activation: Alleviation of Parkin autoinhibition by Ser65 phosphorylation -- PINK1-mediated Parkin translocation and activation: The role of phosphorylated ubiquitin S65 -- Parkin substrates: Ubiquitination of mitochondrial proteins -- Formation of mitophagosomes: The role of mitophagy receptors -- 3.2.2 Metabolic stressors: Alternative mitophagy by outer mitochondrial membrane proteins -- Hypoxia-induced mitophagy -- Starvation-induced mitophagy -- Iron starvation-induced mitophagy -- 3.2.3 Inner mitochondrial membrane and matrix proteins -- Sphingolipids: Ceramide and cardiolipin -- Prohibitin 2 -- NIPSNAP proteins -- 3.2.4 Emerging E3 ligases in mitophagy -- Mul1 and SMURF1 -- Gp78 -- Arih1 -- Siah1 -- cIAP1 -- 4 Interventions targeting mitochondrial biogenesis and mitophagy to enhance mitochondrial health and longevity -- 5 Concluding remarks -- Acknowledgment -- Competing interest -- References -- Chapter 3 DNA transcription and translation in mitochondria -- 1 DNA transcription and translation in mitochondria -- 1.1 The mitochondrial oxidative phosphorylation -- 1.2 The mitochondrial DNA transcription -- 1.2.1 The mtDNA |
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1.2.2 The mtDNA transcription promoter -- 1.2.3 The mtDNA transcription -- 1.2.4 The mtDNA posttranscriptional steps -- Maturation of the primary transcript (endonucleolytic processing) -- Mitochondrial epitranscriptome -- 1.2.5 tRNA aminoacylation -- 1.3 Mitochondrial translation -- 2 Concluding remarks -- Acknowledgment -- References -- Chapter 4 Mitochondrial redox biology: Reactive species production and antioxidant defenses -- 1 Introduction -- 2 Mitochondria, oxidative phosphorylation, and its regulation -- 3 Mitochondrial ROS production and its modulation -- 3.1 Sites of ROS production -- 3.2 Regulation of ROS production -- 4 Mitochondrial systems of antioxidant defense and its modulation -- 4.1 Mitochondrial antioxidant enzymes -- 4.2 Repairing systems -- 4.3 Low-molecular-weight antioxidants -- 4.4 Regulation of mitochondrial antioxidant capacities: The role of Nrf2 -- 5 Mitochondria as sink of ROS -- 6 Mitochondrial ROS removal and ROS signaling -- 7 Conclusion -- References -- Chapter 5 Mitochondria and apoptosis -- 1 Introduction -- 2 Mitochondria and apoptosis -- 2.1 Signaling in apoptosis -- 2.2 Mechanism of MOMP -- 3 Post-MOMP inner mitochondrial membrane remodeling -- 4 Post-MOMP regulation of apoptotic assembly -- 5 Post-MOMP cellular fate -- 6 Survival after MOMP -- 7 Mitochondria and nonapoptotic cell death -- 7.1 Necroptosis -- 7.2 Pyroptosis -- 7.3 Ferroptosis -- 8 Conclusion -- References -- Chapter 6 Mitochondria-associated membranes in the maintenance of cell homeostasis -- 1 Introduction -- 2 MAM and phospholipid synthesis and transfer -- 3 The yeast ERMES complex -- 4 MAM and Ca 2 + signaling -- 5 MAM and apoptotic cell death -- 6 MAM and autophagy/mitophagy -- 6.1 PINK1/Parkin-dependent mitophagy -- 6.2 PINK1/Parkin-independent mitophagy, specific receptor characterization |
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6.3 Role of MAM in providing membranes and PE for autophagy/mitophagy processes -- 6.4 MAM components and autophagy/mitophagy -- 6.5 Localization/relocalization of autophagy/mitophagy actors on MAM -- 7 Concluding remarks -- References -- Part II The effects of plant molecules on the mitochondria in health and disease -- Chapter 7 Biopharmaceutical properties of natural products -- 1 Introduction -- 2 Solubility and dissolution -- 3 Permeability -- 4 Presystemic metabolism -- 5 Biopharmaceutical classification systems -- 6 Novel natural product formulations -- 7 Standardization -- 8 Mitochondrial biopharmaceutics -- 9 Conclusion -- Acknowledgment -- References -- Chapter 8 Carnosic acid and brain mitochondria -- 1 Introduction -- 2 The mitochondria-related effects induced by CA in in vitro experimental model -- 3 The mitochondria-related effects induced by CA in ex vivo/in vivo experimental models -- 4 Conclusion -- 5 Future directions -- Acknowledgments -- References -- Chapter 9 Rosmarinic acid and mitochondria -- 1 Background -- 2 Factors involved in mitochondrial dysfunction -- 3 Pathological basis of mitochondrial dysfunction in diseases -- 3.1 Diabetes and diabetic complications -- 3.2 Central nervous system (CNS) disorders -- 3.2.1 Alzheimer's disease and mitochondrial dysfunction -- 3.2.2 Parkinson's disease and mitochondrial dysfunction -- 3.2.3 Huntington's disease and mitochondrial dysfunction -- 4 Rosmarinic acid and mitochondrial regulation -- 4.1 Rosmarinic acid: Active ingredient of rosemary -- 4.2 Rosmarinic acid in mitochondrial diseases -- 5 Rosmarinic acid in metabolic disease -- 6 Rosmarinic acid in central nervous system diseases -- 7 Pharmacokinetic profile and clinical aspects of Rosmarinic acid -- 8 Conclusions -- Acknowledgments -- Conflict of interest -- References -- Chapter 10 Sulforaphane and mitochondria |
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1 Sulforaphane overview -- 2 Nrf2-dependent impacts of SFN on mitochondrial structure and function -- 3 Nrf2-independent impacts of SFN on mitochondrial structure and function -- 4 Future challenges -- Acknowledgments -- References -- Chapter 11 Cannabinoids and mitochondria -- 1 Introduction -- 2 The endocannabinoid system -- 3 Mitochondria are affected by cannabinoids -- 4 Cannabinoids alter mitochondrial membranes and functions -- 5 Cannabinoid receptors in cannabinoid-dependent alterations of mitochondria -- 5.1 Activation of cannabinoid receptors and OXPHOS -- 5.2 Activation of cannabinoid receptors and apoptosis -- 5.3 Activation of cannabinoid receptors and mitochondrial dynamics -- 6 CBD and mitochondria -- 7 The mitochondrial CB1 -- 8 Protective roles of cannabinoids -- 9 Conclusion -- Acknowledgments -- References -- Chapter 12 Anthocyanins, effects in mitochondria and metabolism -- 1 Introduction -- 2 Anthocyanin molecules, food sources, and bioavailability -- 3 Effects of anthocyanins on mitochondria and metabolism in health and disease -- 3.1 Anthocyanins in mitochondrial physiology -- 3.1.1 Modulation of mitochondrial redox systems and ROS production -- 3.1.2 Effects in mitochondrial dynamics and respiration -- 3.1.3 Promotion of mitochondrial biogenesis -- 3.1.4 Antiapoptotic action -- 3.2 Regulation of mitochondrial function and metabolism in neurodegeneration -- 3.3 Regulation of mitochondrial function and metabolism in cardiovascular diseases -- 3.4 Regulation of mitochondrial function and metabolism in obesity and diabetes -- 3.5 Effects of anthocyanins in models of aging and longevity -- 3.6 Regulation of mitochondrial function and metabolic remodeling in cancer -- 4 Conclusions and future directions -- Acknowledgments -- References |
| Notes |
Description based upon print version of record |
| Subject |
Mitochondrial pathology.
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Mitochondria -- pathology
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Mitochondrial pathology
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| Form |
Electronic book
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| ISBN |
9780128215838 |
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0128215836 |
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