| Description |
1 online resource |
| Contents |
Stress-Induced Mutagenesis in Bacteria / Ivan Matic -- Mutagenesis Associated with Repair of DNA Double-Strand Breaks Under Stress / Chandan Shee, P.J. Hastings, Susan M. Rosenberg -- Transcription-Mediated Mutagenic Processes / Eduardo Robleto, Holly A. Martin, Carmen Vallin -- Transposon Mutagenesis in Disease, Drug Discovery, and Bacterial Evolution / Zhongge Zhang, Jing Wang, Maksim A. Shlykov -- Hsp90 as a Capacitor of Both Genetic and Epigenetic Changes in the Genome During Cancer Progression and Evolution / Xiangyi Lu, Luan Wang, Vincent E. Sollars, Mark D. Garfinkel -- Inheritance of Stress-Induced Epigenetic Changes Mediated by the ATF-2 Family of Transcription Factors / Ki-Hyeon Seong, Toshio Maekawa, Shunsuke Ishii -- Microsatellite Repeats: Canaries in the Coalmine / Nimrat Chatterjee, Beatriz A. Santillan, John H. Wilson -- Genetic Instability Induced by Hypoxic Stress / Susan E. Scanlon, Peter M. Glazer -- Radiation-Induced Delayed Genome Instability and Hypermutation in Mammalian Cells / Christopher P. Allen, Akira Fujimori, Ryuichi Okayasu -- Radiation-Induced Bystander Effects and Stress-Induced Mutagenesis / Carmel Mothersill, Colin Seymour -- Stress Induced Mutagenesis, Genetic Diversification, and Cell Survival via Anastasis, the Reversal of Late Stage Apoptosis / Ho Lam Tang, Ho Man Tang, Denise J. Montell -- The Transgenerational Effects of Parental Exposure to Mutagens in Mammals / Yuri E. Dubrova -- Revisiting Mutagenesis in the Age of High-Throughput Sequencing / Subhajyoti De, R. Matthew Ward |
| Summary |
The discoveries of stress-induced mutation and epigenetic inheritance have challenged the claim of independence between the evolutionary forces of mutation and selection. In "Stress-Induced Mutagenesis", leading experts provide the key evidence for and the molecular details of stress-induced genetic and epigenetic mutation, integrating cross-disciplinary observations from a number of species and biological systems, including human. The observations have vast implications for evolutionary biology but also for human medicine. A comprehensive understanding of stress-induced mutagenesis and the processes underlying evolvability, will enable gains in the treatment and management of cancer, as well as other human disorders that result from damaged or unstable genomes |
| Analysis |
Medicine |
|
Human genetics |
|
Biochemistry |
|
Biomedicine |
|
biomedische wetenschappen |
|
biochemie |
|
humane genetica |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Notes |
Includes index |
| Bibliography |
Cludes bibliographical references |
| Notes |
English |
| In |
Springer eBooks |
| Subject |
Mutagenesis.
|
|
Epigenetics.
|
|
Biochemistry.
|
|
Epigenesis, Genetic
|
|
Mutagenesis
|
|
Stress, Physiological
|
|
Biochemistry
|
|
biochemistry.
|
|
medicines (material)
|
|
SCIENCE -- Life Sciences -- Evolution.
|
|
Epigenetics
|
|
Mutagenesis
|
| Form |
Electronic book
|
| Author |
Mittelman, David
|
| ISBN |
9781461462804 |
|
1461462800 |
|
