| Description |
1 online resource : illustrations |
| Series |
Drug Targeting and Delivery ; volume 5 |
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Drug targeting and delivery ; v. 5.
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| Contents |
Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface to The Series -- Introduction -- List of Symbols -- PART A FUNDAMENTALS -- Chapter 1: Interfacial Phenomena, Surface Tension and Liquid/Liquid Interfaces -- 1.1 Surfaces and interfaces -- 1.2 The liquid/vapour interface -- 1.2.1 The measurement of surface tension -- 1.2.2 The effect of additives on surface tension -- 1.2.3 Foams -- 1.2.4 Concluding comments on the liquid/vapour interface -- 1.3 The liquid/liquid interface -- 1.3.1 Studies on insoluble monolayers -- 1.3.2 Emulsions -- 1.3.2.1 The basic concepts -- 1.3.2.2 Emulsion stability -- 1.3.2.3 Phases and stabilisers -- 1.3.3 Concluding comments on liquid/liquid interfaces -- 1.4 The properties of water -- Chapter 2: The Solid/Liquid Interface -- 2.1 The solid surface -- 2.1.1 Solid surface tension and solid surface energy -- 2.2 Crystalline and amorphous materials -- 2.3 Contact angles -- 2.3.1 The wetting process -- 2.3.2 Factors which affect contact angle -- 2.4 Measurement of contact angles -- 2.4.1 Contact angles on smooth flat surfaces -- 2.4.2 Capillary penetration -- 2.4.3 Measurement of contact angles for powdered systems -- 2.4.3.1 The difficulties with powders -- 2.4.3.2 Contact angles on compacts -- 2.4.3.3 Liquid penetration experiments -- 2.4.4 Comparison of contact angle values obtained from different techniques -- 2.5 Estimation of surface energy values for solids -- 2.5.1 Critical surface tension, yc -- 2.5.2 Polar and dispersion components of surface energy -- 2.5.2.1 The nature of interfacial forces -- 2.5.2.2 Calculation of polar and dispersion forces -- 2.5.3 Theory of non-additive surface energy components -- 2.5.3.1 Calculation of acid-base surface energy parameters -- 2.5.4 Equation of state approaches -- 2.6 Estimating surface energies by use of immersional calorimetry |
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2.7 Adsorption at the solid/liquid interface -- 2.7.1 Isotherms for the adsorption of solute onto solid from solution -- 2.7.2 Factors which affect the extent of adsorption from solution -- 2.7.3 Significance of adsorption at the solid/liquid interface -- Chapter 3: The Solid/Vapour Interface -- 3.1 The basis of adsorption -- 3.2 Clean surfaces -- 3.3 Solid/vapour adsorption isotherms -- 3.3.1 The Langmuir isotherm -- 3.3.2 Type II, III, IV and V physical isotherms -- 3.3.3 Freudlich isotherm -- 3.3.4 Brunauer, Emmett and Teller Isotherm -- 3.3.5 GAB isotherm -- 3.3.6 Polanyi adsorption potential -- 3.4 Capillary condensation -- 3.5 Thermodynamics of adsorption -- 3.5.1 Isosteric studies -- 3.5.2 Calorimetric studies -- 3.5.2.1 An introduction to isothermal microcalorimetry -- 3.6 Interactions between powders and water vapour -- 3.6.1 Water adsorption -- 3.6.2 Water absorption -- 3.6.3 Transfer of water between solids -- 3.6.4 Deliquescence -- 3.6.5 Hydrates -- 3.7 Reverse phase chromatography -- 3.7.1 Adsorption parameters at zero coverage -- 3.7.2 Adsorption isotherms -- Chapter 4: Other Interfacial Phenomena -- 4.1 Solid/solid interfaces -- 4.1.1 Friction -- 4.1.2 Lubrication -- 4.1.3 Adhesion -- 4.2 Aerosols -- 4.2.1 Formation of aerosols -- 4.3 Relationships between interfacial phenomena and other properties -- 4.3.1 Tensile strength -- 4.3.2 Solubility parameter -- 4.4 Electrical aspects of interfaces -- 4.4.1 Sources of charge on materials -- 4.4.2 DLVO theory -- 4.5 Some relationships between interfacial phenomena -- Chapter 5: Surfactants -- 5.1 Types of surfactant -- 5.2 Micelles and surfactant aggregation -- 5.2.1 Micelle formation -- 5.2.2 Determination of the CMC -- 5.2.3 Factors affecting the CMC -- 5.2.4 Other phase behaviour -- 5.2.4.1 Conformation below the CMC -- 5.2.4.2 Cloud point and gel formation -- 5.3 Properties of surfactants |
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5.3.1 Wetting agents -- 5.3.2 Detergency -- 5.3.3 Solubilisation -- 5.4 Surfactants as stabilisers of emulsions and suspensions -- 5.4.1 Emulsions -- 5.4.2 Microemulsions -- 5.4.3 Emulsion stability -- 5.4.3.1 HLB system -- 5.4.3.2 Other stability aspects -- 5.5 Surfactants as stabilisers of suspensions -- 5.6 Nonionic surfactant vesicles -- 5.7 Natural surfactants -- 5.7.1 In the gastrointestinal tract (bile salts) -- 5.7.2 In the lung and eye -- 5.8 Surfactant toxicity -- PART B : PRACTICAL APPLICATIONS -INTERFACIAL PHENOMENA IN PRODUCT DEVELOPMENT AND IN USE -- Chapter 6: Development Aspects -- 6.1 Introduction -- 6.2 Surface energetic considerations in the development of solid dosage forms -- 6.2.1 Mixing and excipient interactions -- 6.2.2 Spreading of binders during wet granulation -- 6.2.3 Adhesion of film coatings to tablets -- 6.2.4 Drug/drug and drug/carrier interactions in dry powder inhalers -- 6.3 Surface energetic considerations in the development of other dosage forms -- 6.3.1 Non-aqueous suspensions (inhalation aerosols) -- 6.3.1.1 Dispersion of solids to form suspensions -- 6.3.1.2 Aggregation of particles in metered dose inhalers -- 6.3.1.3 Adhesion to container walls -- 6.3.2 Aqueous suspensions -- 6.3.3 Packaging -- 6.4 Variability of surfaces -- 6.4.1 Comminution -- 6.4.2 Spray drying -- 6.4.3 Freeze drying -- 6.4.4 Mixing -- 6.4.5 Concluding comments: optimising surfaces for ideal properties. -- Chapter 7: Wettability, Solubility, Dissolution, Partition and Absorption -- 7.1 Introduction -- 7.2 Wettability and solubility -- 7.1.1 Considerations of how aspects of structure relate to wettability -- 7.2.2 Considerations of how aspects of structure relate to solubility -- 7.2.3 Relationships between wettability and solubility -- 7.2.4 Relationships between wettability and the rate of solution -- 7.3 Partition |
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7.3.1 Relationships between wettability, solubility and partition coefficient2 -- 7.3.2 Water dragging effects -- 7.3.3 Choice of solvent and the Collander equation -- 7.4 Absorption across biological membranes -- 7.4.1 Absorption from the gastro-intestinal tract -- 7.4.1.1 General concepts -- 7.4.1.2 Particulate absorption -- 7.4.2 Concluding comments -- Chapter 8: Bioadhesion and Mucoadhesion -- 8.1 Introduction to bioadhesion and mucoadhesion -- 8.1.1 Examples of bioadhesive systems -- 8.2 Interfacial models of bioadhesion -- 8.2.1 Modelling mucoadhesion using surface energies -- 8.2.2 Interpenetration in mucoadhesion -- 8.3 Approaches to the testing of bioadhesive performance -- 8.4 Ocular inserts -- Chapter 9: Interactions of Colloidal Delivery Systems with The Biological Environment -- 9.1 Behaviour of biological components at the solid/liquid interface -- 9.1.1 Flexible polymers -- 9.1.2 Rigid polymers -- 9.1.3 Interfacial predictions of polymer adsorption -- 9.1.4 Enthalpy and entropy of protein adsorption -- 9.2 Functions of protein adsorption -- 9.3 Targeting of colloidal particles -- 9.3.1 Desirable surface properties to prevent opsonisation -- 9.4 Approaches for targeting microspheres to different body sites -- 9.5 Interactions between surfactant coated particles and plasma proteins -- 9.6 The "Stealth" liposome -- Index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed July 3, 2018) |
| Subject |
Drug delivery systems.
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Drug targeting.
|
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Interfaces (Physical sciences)
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Drug Delivery Systems
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MEDICAL -- Pharmacology.
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Drug delivery systems
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Drug targeting
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Interfaces (Physical sciences)
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| Form |
Electronic book
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| ISBN |
9781420022629 |
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1420022628 |
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