| Description |
1 online resource (538 p.) |
| Contents |
Intro -- Foreword -- Preface -- Contents -- Editors and Contributors -- Part I: Human Microbiome, Vaccines and Autoimmunity -- 1: Autoimmunity and Microbiome -- 1.1 Introduction -- 1.2 Microbiota and Immune System Interaction -- 1.3 Microbiota and Autoimmunity -- 1.4 Mechanisms of Autoimmunity Induced by Microbiota -- 1.4.1 Microbiome Translocation -- 1.4.2 Molecular Mimicry -- 1.4.3 Dysregulated Immune Response -- 1.4.3.1 Secretion of Immunosuppressive Cytokines -- 1.4.3.2 Cytolysis -- 1.4.3.3 Metabolic Disruption -- 1.4.3.4 Suppression of DC Maturation and Function -- 1.5 Conclusion |
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2.3.1.1.4 Ankylosing Spondylitis -- 2.3.1.1.5 Scleroderma -- 2.3.1.1.6 Sjogrenś Syndrome -- 2.3.1.2 Organ-Specific Autoimmune Diseases -- 2.3.1.2.1 Type-1 Diabetes Mellitus (T1DM) -- 2.3.1.2.2 Hashimotoś Thyroiditis -- 2.3.1.2.3 Vitiligo -- 2.3.1.2.4 Graves ́Disease -- 2.3.1.2.5 Autoimmune Anemia -- 2.3.1.2.6 Goodpastureś Syndrome -- 2.3.1.2.7 Myasthenia Gravis -- 2.4 Mechanism of Vaccine Triggered Autoimmunity -- 2.4.1 Adjuvants -- 2.4.2 Molecular Mimicry -- 2.4.3 mRNA-Based Vaccines: a Trigger to Autoimmunity -- 2.4.4 Other Mechanisms -- 2.5 Vaccines Reported for Development of Autoimmunity |
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2.5.1 Hepatitis B Vaccines -- 2.5.2 Measles, Mumps, and Rubella (MMR) Vaccines -- 2.5.3 Influenza Vaccine -- 2.5.4 Human Papilloma Virus (HPV) Vaccine -- 2.5.5 SARS-CoV-2 Vaccines -- 2.5.6 Other Vaccines -- 2.6 Conclusions -- References -- 3: COVID-19 and Autoimmunity -- 3.1 Introduction -- 3.2 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) -- 3.3 Virus Infection and Autoimmunity -- 3.3.1 SARS-CoV-2 Induced Autoimmunity -- 3.3.1.1 Molecular Mimicry -- 3.3.1.2 Bystander Activation -- 3.3.1.3 Cytokine Storm -- 3.3.1.4 Autoantibodies -- 3.3.1.5 Innate Immune Mechanisms |
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3.3.1.6 Genetic Susceptibility -- 3.4 Similarities Between COVID-19 Manifestations and Autoimmunity -- 3.5 Autoimmune Complications of COVID-19 -- 3.5.1 Guillain-Barre Syndrome -- 3.5.2 Immune Thrombocytopenic Purpura -- 3.5.3 Kawasaki Disease -- 3.5.4 Autoimmune Thyroid Diseases -- 3.5.5 Rheumatoid Arthritis -- 3.5.6 Systemic Lupus Erythematosus -- 3.5.7 Type 1 Diabetes -- 3.5.8 Vitiligo -- 3.5.9 Alopecia areata -- 3.5.10 Cold Agglutinin Syndrome (CAS) -- 3.5.11 Antiphospholipid Syndrome -- 3.6 Autoimmune Disease: A Risk Factor for Severe COVID-19? -- 3.7 Conclusions -- References |
| Summary |
This book in the two volume set provides comprehensive coverage on how microbial pathogens can subvert our immune system into responding against self and resulting into autoimmune diseases. In particular, the book covers the different aspects of linking gut microbiota dysbiosis with autoimmune mechanisms involved in disease development to identify future effective approaches based on the gut microbiota for preventing these autoimmune diseases. Contributions in the book focuses on the role of microbiota/probiotics and their distinct mechanisms exerted in management of autoimmune liver, skin, thyroid, rheumatic and myopathic diseases. This could help in better understanding to design therapeutic strategies that can be deployed to prevent these autoimmune diseases. The book has an interdisciplinary appeal and scholars with an interest immunology, medical microbiology and nutritional sciences will value its contribution. Overall, the book gives a new dimensions and insight in the aspects of microbial role in autoimmune disease pathogenesis and therapeutic aspects |
| Bibliography |
References -- 2: The Vaccines Induced Autoimmunity -- 2.1 Introduction -- 2.2 Vaccines -- 2.2.1 How Do Vaccines Work? -- 2.2.2 Types of Vaccines -- 2.2.2.1 Live Attenuated Vaccine -- 2.2.2.2 Inactivated Vaccine -- 2.2.2.3 Subunit and Conjugate Vaccines -- 2.2.2.4 Virus Like Particles -- 2.2.2.5 Viral Vector Vaccines -- 2.2.2.6 Nucleic Acid Vaccine -- 2.2.2.7 Toxoids -- 2.3 Autoimmune Diseases -- 2.3.1 Types of Autoimmune Disease -- 2.3.1.1 Systemic Autoimmune Disease -- 2.3.1.1.1 Rheumatoid Arthritis (RA) -- 2.3.1.1.2 Systemic Lupus Erythematosus -- 2.3.1.1.3 Multiple Sclerosis |
| Notes |
4: The Protective Discourse Between Infections and Autoimmunity |
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Includes index |
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Description based on online resource; title from digital title page (viewed on January 31, 2023) |
| Subject |
Autoimmune diseases -- Pathogenesis
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Autoimmune diseases -- Treatment
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Microbial ecology.
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Environmental Microbiology
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Autoimmune diseases -- Treatment
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Microbial ecology
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| Form |
Electronic book
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| Author |
Dwivedi, Mitesh Kumar, editor
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Sankaranarayanan, A., editor
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Kemp, E. Helen, editor
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Shoenfeld, Yehuda, 1948- editor.
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| ISBN |
9789811948008 |
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9811948003 |
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