| Description |
1 online resource |
| Contents |
Cover; Half-Title; Title Page; Copyright Page; Contents; Preface ; 1. General Introduction on Dendrimers, Classical versus Accelerated Syntheses and Characterizations; 1.1 General Introduction; 1.2 Synthesis; 1.2.1 Classical Synthesis Pathways; 1.2.1.1 Divergent growth ; 1.2.1.2 Convergent growth; 1.2.1.3 Orthogonal convergent growth; 1.2.2 Accelerated Approaches; 1.2.2.1 Double-stage convergent method or the hypercore approach; 1.2.2.2 Hypermonomer method or the branched monomer approach; 1.2.2.3 Double-exponential method |
|
1.2.2.4 Orthogonal coupling method or the two-step approach, the two monomers approach, and the AB[sub(2)] -CD[sub(2)] approach1.2.2.5 Other accelerated strategies ; 1.3 Characterization; 1.4 Conclusion; 2. Dendrimer-Nanoparticle Conjugates in Nanomedicine ; 2.1 Introduction; 2.2 Why Dendrimers and Dendrons?; 2.3 Dendrimer NPs Conjugates; 2.3.1 Gold Nanoparticles; 2.3.2 Quantum Dots Dendritic Nanoboxes; 2.3.3 Iron Oxide Nanoparticles; 2.3.3.1 NPs synthesis; 2.3.3.2 Synthesis of dendrons; 2.3.3.3 Nanohybrids; 2.3.3.4 In vivo applications; 2.3.4 Up-Conversion NPs; 2.3.5 Manganese Oxide NPs |
|
2.4 Conclusion3. Dendritic Polymers for the Repair of Tissues; 3.1 Introduction; 3.2 Synthesis and Properties of Dendritic Hydrogels; 3.2.1 Physical Gelation; 3.2.2 Chemical Gelation; 3.3 Tissue Repair and Tissue Engineering Applications; 3.3.1 Tissue Repair; 3.3.2 Tissue Engineering; 3.4 Conclusions; 4. Polyglycerols in Nanomedicine; 4.1 Introduction; 4.2 Chemistry and Chemical Diversification of dPGs; 4.2.1 Origin and Evolution of dPGs Structure; 4.2.2 Chemistry of Linear PGs: Analogue Frequently Overlooked; 4.2.3 Macromonomers of Linear PG: Building Complex Topology |
|
4.2.4 Dendritic PGs: Branched Scaffold with Nanoscale Benefits4.2.5 Well-Defined Hyperbranched PG: dPGs with Random Regularity; 4.2.6 Core Variation of dPG Increases Functionality and Applicability; 4.2.7 Block Copolymers of Dendritic Polyglycerol; 4.2.8 Postpolymerization Modification: Tailoring the Properties of Polyglycerol; 4.2.9 Giant Polyglycerols: Motifs Resulting in Megamers, Microgels, and Hydrogels; 4.3 Forms Guiding Functions: Features of dPGs Architecture; 4.4 Biocompatibility of Dendritic Polyglycerols; 4.5 Nanomedical Applications of dPGs |
|
4.5.1 Supramolecular Platforms of dPGs for Noncovalent Guest Encapsulation4.5.2 Multifunctional dPG-drug Conjugates for Tumor Targeting ; 4.5.3 Designing Functional Architectures Based on PG for Multivalent Interaction; 4.5.3.1 Neutral PGs as mimicry of oligosaccharides for surface modification; 4.5.3.2 Negatively charged dPG derivatives; 4.5.3.3 Applications of polycationic derivatives ofdendritic PGs; 4.5.4 Polyglycerol Nanogel in Biomedicine; 4.6 Opportunities; 4.7 Conclusions; 5. Theranostic Potential of Dendronized Iron Oxide Nanoparticles; 5.1 Introduction |
| Summary |
Nanomedicine can take advantage of the recent developments in nanobiotechnology research for the creation of platforms with superior drug carrier capabilities, selective responsiveness to the environment, unique contrast enhancement profiles, and improved accumulation at the disease site. This book provides a broad glimpse of how various dendritic nanomaterials have been designed and used as efficient tools for nanomedicine. It comprises a pedagogic introduction to dendrimers and hyperbranched systems and their classical and accelerated syntheses through cutting-edge methodologies. The chapters on dendronized magnetic nanoparticles as theranostics, dendrimers in theory (molecular simulations), siRNA delivery with dendrimers, and dendrimers for image-guided therapy, combined with chapters focused on specific types of dendrimers or hyperbranched structures, detail the cutting-edge research in nanomedicine. Finally, a detailed chapter on issues related to the pharmacokinetics and biodistribution of dendrimers helps choose the right structures for successful transfer from bench to bedside. This book will appeal to those involved in nanobiotechnology, macromolecular science, cancer therapy, tissue repair, and siRNA delivery research |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL |
|
Online resource; title from PDF title page (EBSCO, viewed November 10, 2016) |
| Subject |
Dendrimers in medicine.
|
|
Nanomedicine -- Research
|
|
Dendrimers.
|
|
Nanoparticles.
|
|
Nanotechnology.
|
|
Nanomedicine.
|
|
Dendrimers
|
|
Nanoparticles
|
|
Nanomedicine
|
|
Nanotechnology
|
|
TECHNOLOGY & ENGINEERING -- Chemical & Biochemical.
|
|
Nanotechnology
|
|
Nanoparticles
|
|
Dendrimers
|
|
Dendrimers in medicine
|
| Form |
Electronic book
|
| Author |
Felder-Flesch, Delphine, editor
|
| ISBN |
9789814745505 |
|
9814745502 |
|
9781315340845 |
|
1315340844 |
|
