| Description |
1 online resource (514 p.) |
| Contents |
Intro -- Precision Cancer Therapies -- Contents -- List of Contributors -- Volume Foreword -- Volume Preface -- Series Preface -- Section I Biological Basis of the Lymphoid Malignancies -- 1 Fundamental Principles of Lymphomagenesis -- Take Home Messages -- Introduction -- How to Study Lymphomagenesis -- Before Lymphoma: The Gray Frontier Between Physiology and Pathology -- Driver Without Disease -- From In Situ Neoplasms to Asymptomatic Lymphomas -- Chronic Antigenic Stimulation as an Early Step of Lymphomagenesis -- The Cell of Origin Concept: A Classification Based on Physiology |
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What Are the Hallmarks of Lymphoma? -- Epigenetics and Metabolism -- Apoptosis Escape -- Proliferation -- TCR/BCR Signaling -- Immune Escape -- Trafficking -- Microenvironment -- Conclusion -- Must Read References -- References -- 2 Identifying Molecular Drivers of Lymphomagenesis -- Take Home Messages -- Introduction -- Sequencing and Bioinformatics Methods -- Functional Validation of Drivers -- Common Themes in B- and T-cell Lymphoma -- Genetic Landscapes of Lymphomas -- Mature B-cell Lymphomas -- T-cell Lymphomas -- Genomic Subgrouping Approaches in DLBCL |
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Challenges of Incorporating Genomic Subgrouping Approaches in Clinical Trials -- Leveraging Underlying Pathophysiology to Inform Therapeutic Consideration -- Conclusion -- Must Read References -- References -- 3 Characterizing the Spectrum of Epigenetic Dysregulation Across Lymphoid Malignancies -- Take Home Messages -- Introduction: Epigenetics and Lymphoid Malignancies -- Dysregulation of DNA Methylation and Modification of Histone Proteins -- Genes Involved in Histone Modification Implicated in Lymphomagenesis -- Enhancer of Zeste Homolog 2 (EZH2) |
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CREB-binding Protein (CREBBP) and Histone Acetyltransferase P300 (EP300) -- The H3K4 Methyltransferase Family -- The Bromodomain and Extra-Terminal Domain (BET) Family -- Genes Involved in DNA Methylation Implicated in Lymphomagenesis -- DNA Methyltransferase 3A (DNMT3A) -- Ten-Eleven Translocation 1/2 (TET1/2) -- Isocitrate Dehydrogenase 2 (IDH2) -- The Epigenetic Landscape of Specific Lymphoid Malignancies -- Follicular Lymphoma -- Diffuse Large B-cell Lymphoma -- Marginal Zone Lymphoma -- Burkitt's Lymphoma -- Acute Lymphoblastic Leukemia -- Chronic Lymphocytic Leukemia -- Mantle Cell Lymphoma |
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Hodgkin's Lymphoma -- Multiple Myeloma -- Peripheral T-cell Lymphoma -- Not Otherwise Specified -- Angioimmunoblastic T-cell Lymphoma and PTCL with TFH Phenotype -- Anaplastic Large Cell Lymphoma -- Adult T-cell Leukemia/Lymphoma -- Intestinal T-cell Lymphoma -- Hepatosplenic T-cell Lymphomas -- NK/T Cell Lymphoma -- Mycosis Fungoides and Sezary's Syndrome -- Summary -- Must Read References -- References -- 4 Animal Models of Lymphoid Malignancies -- Take Home Messages -- Introduction -- Optimal Animal Models to Study Lymphoid Neoplasms -- Zebrafish Model -- Zebrafish Model of T-cell Neoplasms |
| Notes |
Description based upon print version of record |
|
Zebrafish Model of B-cell Neoplasms |
| Form |
Electronic book
|
| Author |
Ansell, Stephen M
|
|
Seymour, John F
|
| ISBN |
9781119819936 |
|
1119819938 |
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