| Description |
1 online resource (641 pages) |
| Contents |
Intro -- Foreword -- A Cartography of Occupational Cancer Prevention -- References -- Preface -- Acknowledgments -- Contents -- 1: Historical Overview of Occupational Cancer Research -- Early Discoveries -- How Evidence Has Been Accumulated on Selected Associations -- Sources of Evidence on Risk to Humans Due to Chemicals -- Epidemiology -- Animal Experimentation -- Short-Term Tests and Structure-Activity Relationships -- Listing Occupational Carcinogens -- IARC Monographs -- Definite and Probable Occupational Risk Factors for Cancer -- The Evolution of Knowledge -- Interpreting the Lists |
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Illustrative Examples and Controversies -- Polycyclic Aromatic Hydrocarbons (PAHs) -- Diesel and Gasoline Engine Emissions -- Asbestos -- Cadmium and Cadmium Compounds -- Styrene -- 1,3-Butadiene -- Vinyl Chloride -- Radium and Radon -- Some Methodological Considerations -- Industry-Based Studies -- Community-Based Case-Control Studies -- Some Trends in Epidemiologic Research on Occupational Cancer -- Continued Importance of Research on Occupational Cancer -- References -- 2: Genetics, Epigenetics, and Environmental Interactions -- Genetics and Heritability -- Phenotype Versus Genotype |
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Epigenetics -- DNA Methylation -- Histone Modifications -- Non-coding RNA -- microRNA -- Long Non-coding RNA -- Bringing Together the Concepts of Genetics, Epigenetics, and Phenotype -- Gene-Environment Interactions -- Xenobiotic Metabolism and Excretion -- Phase I Polymorphisms and Cancer -- Phase II Polymorphisms and Cancer -- Other Polymorphisms and Cancer -- Population Stratification -- Gene-Gene Interactions -- Genome-Wide Association Studies (GWAS) -- Epigenetics and Environmental/Occupational Exposure -- Summary -- References |
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3: Mechanisms of Environmental and Occupational Carcinogenesis -- Environmental and Occupational Carcinogenesis -- Field Cancerization and Expanding Fields -- Environmental and Occupational Sources of DNA Damage -- Physical Carcinogens -- Chemical Carcinogenesis -- Endogenous Mechanisms Activated by Exogenous Exposures -- DNA Repair -- Direct Reversal Repair -- Base Excision Repair -- Nucleotide Excision Repair -- Mismatch Repair -- Interstrand Cross-Link Repair -- Double-Strand DNA Break Repair -- DNA Damage Tolerance -- Apoptosis -- Genetic Mutations -- Epigenetics and Cancer |
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DNA Methylation and Cancer -- Environmental and Occupational Epigenetic Effectors -- Histone Modification -- CpG Methylation and Point Mutations -- Somatic Mutations in Epigenetic Regulators -- Inflammation and Reactive Oxygen Species -- Endocrine Disruption -- References -- 4: Head and Neck Cancers -- Introduction -- Descriptive Epidemiology -- Nasopharynx Cancer -- Nonoccupational Risk Factors -- Occupational Risk Factors -- Oral and Pharyngeal Cancers -- Occupations and Agents with Less Than Sufficient Evidence -- Formaldehyde -- Wood Dust and Wood Industry Work |
| Summary |
This up-to-date review of the literature on the epidemiology and pathology of work-related cancers also includes sensitive diagnostic questionnaires and data on the risk ratios of differing cancers in relation to a variety of occupations and lifestyle factors |
| Notes |
Leather Dust and Leather Industry Work |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Cancer.
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Occupational diseases.
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Medicine, Industrial.
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Neoplasms
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Occupational Diseases
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Occupational Medicine
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Cancer
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Medicine, Industrial
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Occupational diseases
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| Genre/Form |
Electronic books
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| Form |
Electronic book
|
| Author |
Anttila, Sisko L.
|
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Boffetta, Paolo.
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| ISBN |
3030307662 |
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3030307654 |
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9783030307653 |
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9783030307677 |
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3030307670 |
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9783030307684 |
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3030307689 |
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9783030307660 |
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