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Book Cover
Author Vallat, Jean-Michel

Title Peripheral Nerve Disorders : Pathology and Genetics
Published Hoboken : Wiley, 2014


Description 1 online resource (320 pages)
Contents Peripheral nerve disorders: pathology and genetics; Copyright; Contents; Contributor list; Preface; Abbreviations; Chapter 1 Clinical assessment and classification of peripheral nerve diseases; Pathophysiology; Clinical examination; Pattern of distribution of nerve involvement; Medical history; Clinical presentation; Examination; Electrophysiological examination; Electromyography; Nerve conduction studies; Laboratory investigations in peripheral neuropathies; Clinical classification of peripheral neuropathies; Indications for nerve biopsy; Nerve selection
Indications for and information from nerve biopsyReferences; Chapter 2 Combined muscle and nerve biopsy; Introduction; Technique; Results; Vasculitis; Intra-vascular lymphoma; Sarcoidosis; Amyloid polyneuropathies; Mitochondrial cytopathies; Storage diseases; Cholesterol emboli; References; Chapter 3 Cutaneous nerve biopsy; Introduction; Technique; Skin biopsy and location; Tissue preparation; Quantification of intra-epidermal nerve fiber density; Results; Morphology of intra-epidermal and dermal nerve fibers; Autonomic innervation
Examples of the diagnostic value of cutaneous nerve biopsy in peripheral nerve diseaseSmall fiber neuropathy; Diabetic neuropathy; Hereditary neuropathies; Demyelinating and vasculitic neuropathies; Nerve regeneration; Conclusions and recommendations for practical application; References; Chapter 4 Methods for examination of peripheral nerve; General considerations; Nerve biopsy; Postmortem examination; Methods for evaluating nerve biopsies; Routine histology (paraffin embedding); Immunohistochemistry; Plastic-resin embedding; Frozen sections for immunofluorescence
Dissociation of fibers (nerve teasing)Frozen specimens for molecular analysis; Electron microscopy; Quantitative and morphometric analyses; References; Chapter 5 Complications from nerve biopsy; Introduction: My nerve biopsy; Frequency of complications; When to perform a nerve biopsy; Predicting complications; Reducing complications; References; Chapter 6 Anatomy of the peripheral nerve; Introduction; Normal anatomy of peripheral nerves; The nerve trunk; Axons; Myelinated nerve fibers; Unmyelinated axons; End organs; Sensory endings; Variations according to age; Development; Age changes
Summary Peripheral Nerve Disorders: Pathology and Genetics is a definitive, clinically-oriented guide to the pathology of peripheral nerve disorders. These commonly seen neurological challenges have many causes and accurate diagnosis is often necessary via pathological analysis. New techniques exploiting molecular biological knowledge have opened up new vistas to understanding the pathogenesis of these disorders, and hence their effective management. This new title takes a disease-oriented approach to understanding the pathology of these conditions. It combines classica
Bibliography ReferencesChapter 7 Basic pathology of the peripheral nervous system; Introduction; Changes in myelin sheaths; Demyelination and remyelination; Onion bulb formation; Disorders characterized by demyelination; Myelin alterations in axonal disorders; Hypertrophy of myelin sheaths; Other characteristic myelin changes; Alterations of axons; Wallerian degeneration; Developmental disturbances of peripheral neurons; Inherited axonal neuropathies; Intermediate (axonal and demyelinating) forms of neuropathy; Alterations of unmyelinated nerve fibers; Endoneurial connective tissue changes
Notes Perineurial changes
Print version record
Subject Nervous system -- Diseases
Evidence-based medicine.
Peripheral Nervous System Diseases -- physiopathology
Peripheral Nervous System Diseases -- genetics
Nervous System Diseases
Evidence-based medicine
Nervous system -- Diseases
Form Electronic book
Author Weis, Joachim
ISBN 9781118618400