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E-book

Title Urinary tract / Karl-Erik Andersson, Martin C. Michel, editors
Published Berlin ; Heidelberg ; New York : Springer, ©2011

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Description 1 online resource (xii, 577 pages) : illustrations
Series Handbook of experimental pharmacology ; v. 202
Handbook of experimental pharmacology ; v. 202.
Contents 880-01 Machine generated contents note: 1. Introduction / Christopher Chapple -- 1.1. Innervation / Christopher Chapple -- 1.2. Sphincteric Mechanisms / Christopher Chapple -- 1.3. Lower Urinary Tract Symptoms / Christopher Chapple -- 1.4. Urodynamic Parameters / Christopher Chapple -- References / Christopher Chapple -- 1. Introduction / Marcus J. Drake / Brian A. Parsons -- 2. The Problem / Marcus J. Drake / Brian A. Parsons -- 3. Pathophysiology of OAB / Marcus J. Drake / Brian A. Parsons -- 4. Current Management of OAB / Marcus J. Drake / Brian A. Parsons -- 5. Importance of Animal Models / Marcus J. Drake / Brian A. Parsons -- 6. Difficulties Interpreting Results from Studies Using Animal Models / Marcus J. Drake / Brian A. Parsons -- 6.1. The Difficulty in Developing Animal Models of OAB / Marcus J. Drake / Brian A. Parsons -- 7. Animal Models of OAB / Marcus J. Drake / Brian A. Parsons -- 7.1. Peripheral Versus Central Models / Marcus J. Drake / Brian A. Parsons
880-01/(S Contents note continued: 2.2. Specific Formulations in OAB / Cees Korstanje / Walter Krauwinkel -- 2.3. Urinary Excretion as Targeting Mechanism in Bladder Diseases / Cees Korstanje / Walter Krauwinkel -- 2.4. Intravesical Administration / Walter Krauwinkel / Cees Korstanje -- 2.5. Other Ways to Manipulate Drug Distribution / Cees Korstanje / Walter Krauwinkel -- 3. Conclusions / Cees Korstanje / Walter Krauwinkel -- References / Walter Krauwinkel / Cees Korstanje -- 1. Introduction / Yoshihiko Ito / Shizuo Yamada -- 1.1.α1Adrenoceptor Subtypes / Shizuo Yamada / Yoshihiko Ito -- 1.2. Localization in the Urinary Tract / Shizuo Yamada / Yoshihiko Ito -- 2. Pharmacology of αAdrenoceptor Antagonists / Shizuo Yamada / Yoshihiko Ito -- 2.1. Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms / Shizuo Yamada / Yoshihiko Ito -- 2.2.ai-Adrenoceptor Antagonists / Shizuo Yamada / Yoshihiko Ito -- 3. Prostate / Shizuo Yamada / Yoshihiko Ito
Note continued: 7.2. Induced Hypersensitivity/Inflammatory Models / Marcus J. Drake / Brian A. Parsons -- 7.3. Bladder Outlet Obstruction Model / Marcus J. Drake / Brian A. Parsons -- 7.4. Spontaneous Hypertensive Rat / Marcus J. Drake / Brian A. Parsons -- 7.5. The Hyperlipidaemic Rat / Marcus J. Drake / Brian A. Parsons -- 7.6. Neurological Models / Marcus J. Drake / Brian A. Parsons -- 7.7. Transgenic Animal Models / Marcus J. Drake / Brian A. Parsons -- 8. Conclusions / Marcus J. Drake / Brian A. Parsons -- References / Marcus J. Drake / Brian A. Parsons -- 1. Introduction / Margot S. Damaser / Hai-Hong Jiang -- 2. Methods of Determining SUI in Animal Models / Margot S. Damaser / Hai-Hong Jiang -- 2.1. Sneeze Testing / Margot S. Damaser / Hai-Hong Jiang -- 2.2. Manual LPP Testing / Margot S. Damaser / Hai-Hong Jiang -- 2.3. Vertical Tilt Table LPP Testing / Margot S. Damaser / Hai-Hong Jiang -- 2.4. Electrical Stimulation LPP Testing / Margot S. Damaser / Hai-Hong Jiang
Note continued: 2.5. Urethral Closure Pressure Testing / Margot S. Damaser / Hai-Hong Jiang -- 3. SUI Animal Models / Margot S. Damaser / Hai-Hong Jiang -- 3.1. Models Simulating Childbirth Injury / Margot S. Damaser / Hai-Hong Jiang -- 3.2. Models Simulating Anatomic Support Damage / Margot S. Damaser / Hai-Hong Jiang -- 3.3. Models Simulating Intrinsic Urethra Deficit / Margot S. Damaser / Hai-Hong Jiang -- 4. Treatment Testing on SUI Animal Models / Margot S. Damaser / Hai-Hong Jiang -- 4.1. Pharmacological Therapy Testing / Margot S. Damaser / Hai-Hong Jiang -- 4.2. Sling Surgical Procedures / Margot S. Damaser / Hai-Hong Jiang -- 4.3. Cell-Based Therapy Testing / Margot S. Damaser / Hai-Hong Jiang -- 5. Summary and Perspective on SUI Animal Models / Margot S. Damaser / Hai-Hong Jiang -- References / Margot S. Damaser / Hai-Hong Jiang -- 1. Introduction / J. Paul Hieble -- 2. Measurement of Prostatic Smooth Muscle Tone / J. Paul Hieble
Note continued: 4.3. Effect of Sacral Neuromodulation in Fowler's Syndrome / Derek J. Griffiths -- 4.4. Ice Water (Bladder Cooling) Test / Derek J. Griffiths -- 5. Overactive Bladder Syndrome: Urge Incontinence, Urgency, and Detrusor Overactivity / Derek J. Griffiths -- 5.1. Overactive Bladder: Symptoms and Urodynamics / Derek J. Griffiths -- 5.2. Urgency / Derek J. Griffiths -- 5.3. Detrusor Overactivity / Derek J. Griffiths -- 5.4. Effect of Sacral Neuromodulation in Urge Incontinence / Derek J. Griffiths -- 5.5. Effect of Biofeedback Therapy on Urge Incontinence / Derek J. Griffiths -- 6. Conclusion / Derek J. Griffiths -- References / Derek J. Griffiths -- 1. Introduction / Gert Holstege / Jonathan M. Beckel -- 2. The Anatomy and Innervation of the Lower Urinary Tract / Gert Holstege / Jonathan M. Beckel -- 2.1. The Gross Anatomy of the Lower Urinary Tract / Gert Holstege / Jonathan M. Beckel
Note continued: 2.2. Peripheral Innervation of the Lower Urinary Tract / Gert Holstege / Jonathan M. Beckel -- 2.3. Central Circuits Controlling the Lower Urinary Tract / Gert Holstege / Jonathan M. Beckel -- 2.4. Higher Brain Centers Involved in Voluntary Voiding / Gert Holstege / Jonathan M. Beckel -- 3. Conclusions / Gert Holstege / Jonathan M. Beckel -- References / Gert Holstege / Jonathan M. Beckel -- 1. Introduction / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 1.1. Sex Differences / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 1.2. Species Differences / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 1.3. Embryology / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 2. Anatomy of the Human LUT and Pelvic Floor / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner
Note continued: 2.1. The Urethra and Its Accessory Glands / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 2.2. The Human Pelvic Floor / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 3. Anatomy and Development of the Rodent LUT and "Pelvic Floor" / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 3.1. The Components of the Rodent LUT / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 3.2. The Muscles of the Rodent LUT / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 3.3. The Pelvic Floor Muscles in the Mouse / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- References / Wisuit Pradidarcheep / Wouter H. Lamers / Noshir F. Dabhoiwala / Christian Wallner -- 1. Introduction / Gert Holstege / Jonathan M. Beckel
Note continued: 2. Neural Circuits Controlling the Lower Urinary Tract / Gert Holstege / Jonathan M. Beckel -- 2.1. The Storage Reflex / Gert Holstege / Jonathan M. Beckel -- 2.2. Voiding Reflexes / Gert Holstege / Jonathan M. Beckel -- 3. The Role of the Brain in Voluntary Voiding / Gert Holstege / Jonathan M. Beckel -- 3.1. The Anterior Cingulate Gyrus / Gert Holstege / Jonathan M. Beckel -- 3.2. Prefrontal Cortex / Jonathan M. Beckel / Gert Holstege -- 4. Central Nervous System Pharmacology Controlling Micturition / Jonathan M. Beckel / Gert Holstege -- 5. Central Causes of Pathophysiology of the Lower Urinary Tract / Jonathan M. Beckel / Gert Holstege -- 5.1. Spinal Cord Transection / Jonathan M. Beckel / Gert Holstege -- 5.2. Urge Urinary Incontinence / Gert Holstege / Jonathan M. Beckel -- 6. Conclusions / Gert Holstege / Jonathan M. Beckel -- References / Gert Holstege / Jonathan M. Beckel -- 1. Introduction / Anthony J. Kanai -- 2. Afferent Recordings / Anthony J. Kanai
Note continued: 2.1. Multi- and Single-Unit Recordings / Anthony J. Kanai -- 2.2. Patch Clamp Recording / Anthony J. Kanai -- 2.3. Afferent Recording and Optical Mapping / Anthony J. Kanai -- 3. Afferent Nerve Localization Within the Bladder Wall / Anthony J. Kanai -- 3.1. Peripheral and Central Pathways / Anthony J. Kanai -- 3.2. Myelinated AS-and Unmyelinated C-Fibers / Anthony J. Kanai -- 3.3. Chemo-, Mechano-, and Thermo-Sensitivity / Anthony J. Kanai -- 3.4. Mucosal, Muscle, and Serosal Afferents / Anthony J. Kanai -- 3.5. Pelvic Organ Cross Innervation / Anthony J. Kanai -- 4. Receptors on Afferent Neurons / Anthony J. Kanai -- 4.1. Vanilloids (Table 2) / Anthony J. Kanai -- 4.2. Purinergics / Anthony J. Kanai -- 4.3. Muscarinics / Anthony J. Kanai -- 4.4. Other Receptors / Anthony J. Kanai -- 5. Afferent Adaptation / Anthony J. Kanai -- 5.1. Peripheral and Central Afferent Sensitization / Anthony J. Kanai -- 5.2. Myogenic Enhancement of Afferent Firing / Anthony J. Kanai
Note continued: 6. New Pharmacological Approaches / Anthony J. Kanai -- 7. Conclusion / Anthony J. Kanai -- References / Anthony J. Kanai -- 1. Anatomy and Barrier Function of the Urothelium / Lori A. Birder -- 2. Urothelial Heterogeneity / Lori A. Birder -- 3. Evidence Suggesting a Role for Urothelial Cells in Visceral Sensation / Lori A. Birder -- 4. Involvement of the Urothelium in "Sensing" Chemical and Mechanical Stimuli / Lori A. Birder -- 5. Urothelial Sensor Targets and Mediators / Lori A. Birder -- 5.1. ATP and Purinergic Receptors / Lori A. Birder -- 5.2. TRPV1 Channels / Lori A. Birder -- 5.3. Additional TRP Channels / Lori A. Birder -- 5.4. Nicotinic and Muscarinic Acetylcholine Receptors / Lori A. Birder -- 5.5. Estrogen and Estrogen Receptors / Lori A. Birder -- 5.6. Adrenergic Receptors / Lori A. Birder -- 5.7. Nitric Oxide / Lori A. Birder -- 6. Pathology-Induced Urothelial Plasticity and Effect on Barrier Function / Lori A. Birder
Note continued: 7. Clinical Significance of the Sensory Web / Lori A. Birder -- 8. Conclusions: Potential Clinical Implications / Lori A. Birder -- References / Lori A. Birder -- 1. ICC in the Urinary Tract / Karen D. McCloskey -- 2. Nomenclature / Karen D. McCloskey -- 3. Urinary Bladder / Karen D. McCloskey -- 3.1. Location and Morphology of Bladder ICC / Karen D. McCloskey -- 3.2. Physiological Properties of Bladder ICC / Karen D. McCloskey -- 3.3. Clinical Significance of Bladder ICC / Karen D. McCloskey -- 4. Urethra / Karen D. McCloskey -- 4.1. Location and Morphology of ICC in the Urethral Wall / Karen D. McCloskey -- 4.2. Physiological Properties of Urethral ICC / Karen D. McCloskey -- 4.3. Functional Role of Urethral ICC / Karen D. McCloskey -- 5. Upper Urinary Tract: Renal Pelvis and Ureter / Karen D. McCloskey -- 5.1. Location and Morphology of ICC in the Upper Urinary Tract / Karen D. McCloskey
Note continued: 5.2. Physiological Properties of Upper Urinary Tract ICC / Karen D. McCloskey -- 5.3. Functional Implications of ICC in the Upper Urinary Tract / Karen D. McCloskey -- 6. Future Perspectives for Urinary Tract ICC / Karen D. McCloskey -- References / Karen D. McCloskey -- 1. Introduction to Gene Therapy / George J. Christ -- 2. Current Clinical Applications of Gene Therapy / George J. Christ -- 3. The Current Status of Gene Therapy for the Lower Urinary Tract / George J. Christ -- 4. Preclinical Investigations of Gene Therapy for the Lower Urinary Tract: A Variety of Targets and Possibilities / George J. Christ -- 5. Tuning Gene Therapy for the Lower Urinary Tract / George J. Christ -- 6. Summary and Conclusions / George J. Christ -- References / George J. Christ -- 1. Introduction / Walter Krauwinkel / Cees Korstanje -- 2. Mechanisms of Drug Targeting / Cees Korstanje / Walter Krauwinkel -- 2.1. Prodrugs in OAB / Walter Krauwinkel / Cees Korstanje
Note continued: 3.1.mRNA Expression / Shizuo Yamada / Yoshihiko Ito -- 3.2. Protein Expression / Shizuo Yamada / Yoshihiko Ito -- 3.3. Functions / Shizuo Yamada / Yoshihiko Ito -- 4. Urethra / Shizuo Yamada / Yoshihiko Ito -- 4.1.mRNA and Protein Expression / Shizuo Yamada / Yoshihiko Ito -- 4.2. In Vitro and In Vivo Effects / Shizuo Yamada / Yoshihiko Ito -- 5. Bladder / Shizuo Yamada / Yoshihiko Ito -- 5.1.mRNA Expression / Shizuo Yamada / Yoshihiko Ito -- 5.2. Protein Expression / Yoshihiko Ito / Shizuo Yamada -- 5.3. Functions / Yoshihiko Ito / Shizuo Yamada -- 6. Ureter / Yoshihiko Ito / Shizuo Yamada -- 6.1.mRNA and Protein Expression / Yoshihiko Ito / Shizuo Yamada -- 6.2. In Vitro and In Vivo Effects / Yoshihiko Ito / Shizuo Yamada -- 7. Central Nervous System / Yoshihiko Ito / Shizuo Yamada -- 8. Conclusion / Yoshihiko Ito / Shizuo Yamada -- References / Yoshihiko Ito / Shizuo Yamada -- 1. Introduction / Martin C. Michel -- 2. Methodological Aspects / Martin C. Michel
Note continued: 3. Ureter / Martin C. Michel -- 4. Bladder / Martin C. Michel -- 5. Prostate / Martin C. Michel -- 6. Urethra / Martin C. Michel -- 7. Drugs in Clinical Development / Martin C. Michel -- 8. Conclusions / Martin C. Michel -- References / Martin C. Michel -- 1. Introduction / K.E. Andersson -- 1.1. Muscarinic Acetylcholine Receptors / K.E. Andersson -- 2. Bladder / K.E. Andersson -- 2.1. Cholinergic Nerves / K.E. Andersson -- 2.2. Muscarinic Acetylcholine Receptors / K.E. Andersson -- 2.3. Receptor Distribution and Function / K.E. Andersson -- 2.4. Receptor Changes in Disease / K.E. Andersson -- 3. Urethra / K.E. Andersson -- 3.1. Cholinergic Nerves / K.E. Andersson -- 3.2. Receptor Distribution and Function / K.E. Andersson -- 3.3. Changes in Disease / K.E. Andersson -- 4. Prostate / K.E. Andersson -- 4.1. Cholinergic Nerves / K.E. Andersson -- 4.2. Muscarinic Receptors / K.E. Andersson -- 4.3. Distribution and Function / K.E. Andersson
Note continued: 4.4. Changes in Disease / K.E. Andersson -- 5. Ureter / K.E. Andersson -- 5.1. Cholinergic Nerves / K.E. Andersson -- 5.2. Muscarinic Receptors / K.E. Andersson -- 5.3. Distribution and Function / K.E. Andersson -- 5.4. Receptor Changes in Disease / K.E. Andersson -- 6. Muscarinic Receptor Agonists / K.E. Andersson -- 7. Muscarinic Receptor Antagonists / K.E. Andersson -- 8. Summary and Perspectives / K.E. Andersson -- References / K.E. Andersson -- 1. General Characteristics of the TRPV 1 Receptor / Ana Charrua / Francisco Cruz / António Avelino -- 1.1. Localization of TRPV 1 Protein in Lower Urinary Tract / Francisco Cruz / António Avelino / Ana Charrua -- 1.2. The Role of TRPV 1 on Lower Urinary Tract Function and Dysfunction / Ana Charrua / Francisco Cruz / António Avelino -- 1.3. TRPV 1 Regulatory Mechanisms During LUT Inflammation / Ana Charrua / Francisco Cruz / António Avelino
Note continued: 1.4. Mechanisms of TRPV1 Desensitization / Ana Charrua / Francisco Cruz / António Avelino -- 1.5. TRPV1 Antagonists / Ana Charrua / Francisco Cruz / António Avelino -- 1.6. Clinical Perspective of TRPV1 Targeting / Ana Charrua / Francisco Cruz / António Avelino -- 2. General Characteristics of Botulinum Toxin / Ana Charrua / Francisco Cruz / António Avelino -- 2.1. BoNT Mechanism of Action / Ana Charrua / Francisco Cruz / António Avelino -- 2.2. BoNT/A and the Urinary Bladder / Ana Charrua / Francisco Cruz / António Avelino -- 2.3. BoNT/A and the Prostate / Ana Charrua / Francisco Cruz / António Avelino -- 2.4. Clinical Implications in the Usage of BoNT/A / Ana Charrua / Francisco Cruz / António Avelino -- 3. Future Directions / Ana Charrua / Francisco Cruz / António Avelino -- References / Ana Charrua / Francisco Cruz / António Avelino -- 1. Introduction / K.L. Brain / A.F. Brading -- 2. Potassium Channels / A.F. Brading / K.L. Brain
Note continued: 2.1.4TM Channels / K.L. Brain / A.F. Brading -- 2.2.2TM Channels / K.L. Brain / A.F. Brading -- 2.3.6TM Channels / K.L. Brain / A.F. Brading -- 3. TRP Channels / K.L. Brain / A.F. Brading -- 4. Ca2+ Channels / K.L. Brain / A.F. Brading -- 4.1. Store-Operated Ca2+ Channels / K.L. Brain / A.F. Brading -- 5. CF Channels / K.L. Brain / A.F. Brading -- 5.1. Types of Cl- Channels and Their Functions / K.L. Brain / A.F. Brading -- 6. Na+ Channels / K.L. Brain / A.F. Brading -- 7. Ion Channels in Urinary Tract Smooth Muscles / K.L. Brain / A.F. Brading -- 7.1. Distribution of Ion Channels / K.L. Brain / A.F. Brading -- 7.2. Potential Benefit of Modulating Ion Channels / A.F. Brading / K.L. Brain -- 8. Conclusion / K.L. Brain / A.F. Brading -- 8.1.A Speculative Approach / K.L. Brain / A.F. Brading -- References / K.L. Brain / A.F. Brading -- 1. Introduction: Micturition Overview and Anatomy of Lower Urinary Tract / Margaret A. Vizzard / Lauren Arms
Note continued: 1.1. Neural Control of Micturition / Margaret A. Vizzard / Lauren Arms -- 1.2. Neurochemistry and Morphology of Afferent and Spinal Pathways to the Urogenital Tract / Margaret A. Vizzard / Lauren Arms -- 1.3. Neurochemical Plasticity in the LUT with Bladder Inflammation, Neural Injury, or Disease / Margaret A. Vizzard / Lauren Arms -- 2. PACAP/VIP and Associated Receptors Signaling in the LUT / Margaret A. Vizzard / Lauren Arms -- 2.1. PACAP/Receptors in Micturition Reflex Pathways / Margaret A. Vizzard / Lauren Arms -- 2.2. PACAP Expression in Bladder Afferent Pathways and Regulation by CYP-Induced Cystitis / Margaret A. Vizzard / Lauren Arms -- 2.3. PACAP/VIP Receptor Expression in LUT and Modulation with Cystitis / Margaret A. Vizzard / Lauren Arms -- 2.4. PACAP in Micturition Reflexes and Modulation After Spinal Cord Injury / Margaret A. Vizzard / Lauren Arms
Note continued: 2.5. PACAP and VIP Expression and Effects on Major Pelvic Ganglion Neurons / Margaret A. Vizzard / Lauren Arms -- 2.6. PACAP Null lax Exhibit Altered Bladder Function and Somatic Sensitivity / Margaret A. Vizzard / Lauren Arms -- 2.7. VIP/Receptors and Micturition Reflex Pathways / Margaret A. Vizzard / Lauren Arms -- 2.8. PACAP-Mediated ATP Release from Cultured, Rat Urothelium / Margaret A. Vizzard / Lauren Arms -- 3. Tachykinins and Calcitonin-Gene Related Peptide in Micturition Reflex Pathways / Margaret A. Vizzard / Lauren Arms -- 3.1. Tachykinins and CGRP in Micturition Reflex Pathways and Regulation with Inflammation, Injury, or Disease / Margaret A. Vizzard / Lauren Arms -- 3.2. SP and CGRP Plasticity in LUT Pathways with CYP-Induced Cystitis / Margaret A. Vizzard / Lauren Arms -- 4. Role of Neurotrophic Factors in Neuropeptide Expression in Micturition Pathways after CYP-Induced Cystitis / Margaret A. Vizzard / Lauren Arms
Note continued: 5. Bradykinin/Receptors System in Micturition Reflex Pathways / Margaret A. Vizzard / Lauren Arms -- 5.1. Bradykinin/Receptors in Cystitis / Margaret A. Vizzard / Lauren Arms -- 6. Endothelin/Receptors System in LUT Pathways / Margaret A. Vizzard / Lauren Arms -- 6.1. Endothelin/Receptor System in Bladder Outlet Obstruction and Spinal Cord Transection / Margaret A. Vizzard / Lauren Arms -- 6.2. Endothelin/Receptor Systems in the Urethra / Lauren Arms / Margaret A. Vizzard -- 7. Perspectives / Margaret A. Vizzard / Lauren Arms -- References / Margaret A. Vizzard / Lauren Arms -- 1. Introduction / Michael R. Ruggieri, Sr -- 2. Cannabinoids and Their Receptors in the Urinary Tract / Michael R. Ruggieri, Sr -- 2.1. Endogenous Cannabinoids and Metabolism / Michael R. Ruggieri, Sr -- 2.2. Drugs Acting on Cannabinoid Receptors / Michael R. Ruggieri, Sr
Note continued: 2.3. Cellular Location of Cannabinoid Receptors in the Urinary Tract and CNS Areas Involved in Control of Urinary Tract Function / Michael R. Ruggieri, Sr -- 2.4. Effects of Cannabinoid Receptors on Normal Urinary Bladder Function / Michael R. Ruggieri, Sr -- 2.5. Cannabinoid Effects on Inflamed Bladder / Michael R. Ruggieri, Sr -- 2.6. Clinical Studies of Cannabinoids for Control of Bladder Dysfunction in Multiple Sclerosis / Michael R. Ruggieri, Sr -- 3. Conclusions / Michael R. Ruggieri, Sr -- References / Michael R. Ruggieri, Sr -- 1. Introduction / Hashim Hashim / Sailaja Pisipati -- 2. Vasopressin Receptors / Hashim Hashim / Sailaja Pisipati -- 2.1. Types of Receptors / Hashim Hashim / Sailaja Pisipati -- 2.2. Distribution / Hashim Hashim / Sailaja Pisipati -- 3. Basic Pharmacology / Hashim Hashim / Sailaja Pisipati -- 3.1.V1 Receptor Effector Coupling / Hashim Hashim / Sailaja Pisipati
Note continued: 3.2.V2 Receptor Effector Coupling / Hashim Hashim / Sailaja Pisipati -- 4. Functions of Vasopressin / Hashim Hashim / Sailaja Pisipati -- 4.1. Renal Actions of Vasopressin / Hashim Hashim / Sailaja Pisipati -- 4.2. Non-Renal Actions of Vasopressin / Hashim Hashim / Sailaja Pisipati -- 5. Vasopressin: Like Peptides and Their Clinical Utility / Hashim Hashim / Sailaja Pisipati -- 5.1. Urological Applications / Hashim Hashim / Sailaja Pisipati -- 5.2. Non-Urological Applications of Vasopressin and Agonists / Hashim Hashim / Sailaja Pisipati -- 6. Vasopressin Antagonists / Hashim Hashim / Sailaja Pisipati -- 6.1. Clinical Utility of Vasopressin Receptor Antagonists / Hashim Hashim / Sailaja Pisipati -- 7. Mutations / Hashim Hashim / Sailaja Pisipati -- 8. Conclusion / Hashim Hashim / Sailaja Pisipati -- References / Hashim Hashim / Sailaja Pisipati -- 1. Introduction / Debra A. Cockayne / Anthony P.D.W. Ford
Note continued: 1.1. Purinergic Efferent and Afferent Function / Anthony P.D.W. Ford / Debra A. Cockayne -- 1.2. ATP: The Ubiquitous Signaling Factor / Debra A. Cockayne / Anthony P.D.W. Ford -- 1.3.P2X Receptors / Debra A. Cockayne / Anthony P.D.W. Ford -- 2. ATP, Urinary Function, and Dysfunction / Debra A. Cockayne / Anthony P.D.W. Ford -- 2.1. Evidence of a Role for ATP in the Urinary Tract / Debra A. Cockayne / Anthony P.D.W. Ford -- 2.2.P2X Receptors and Urinary Tract Function / Debra A. Cockayne / Anthony P.D.W. Ford -- 3.P2X Receptors as Therapeutic Targets for Urinary Tract Disorders / Debra A. Cockayne / Anthony P.D.W. Ford -- 3.1.P2X1 Receptor Antagonism / Debra A. Cockayne / Anthony P.D.W. Ford -- 3.2.P2X3 and P2X2/3 Receptor Antagonism / Debra A. Cockayne / Anthony P.D.W. Ford -- 4. Conclusions / Debra A. Cockayne / Anthony P.D.W. Ford -- References / Anthony P.D.W. Ford / Debra A. Cockayne -- 1. Introduction / Markus A. Kuczyk / Stefan Ückert
Note continued: 2. Soluble Guanylyl Cyclase / Markus A. Kuczyk / Stefan Ückert -- 3. Phosphodiesterase Isoenzymes / Markus A. Kuczyk / Stefan Ückert -- 4. Cyclic Nucleotide-Binding Protein Kinases / Markus A. Kuczyk / Stefan Ückert -- 5. Targets for the Pharmacological Modulation of the Cyclic AMP/Cyclic GMP Signaling in the LUT / Stefan Ückert / Markus A. Kuczyk -- 5.1. Prostate / Markus A. Kuczyk / Stefan Ückert -- 5.2. Urinary Bladder / Stefan Ückert / Markus A. Kuczyk -- 5.3. Ureter / Markus A. Kuczyk / Stefan Ückert -- 5.4. Urethra / Stefan Ückert / Markus A. Kuczyk -- 6. Conclusion / Markus A. Kuczyk / Stefan Ückert -- References / Markus A. Kuczyk / Stefan Ückert -- 1. Introduction / Michael E. DiSanto / Xinhua Zhang -- 2. Smooth Muscle Contraction / Michael E. DiSanto / Xinhua Zhang -- 3. Calcium Sensitization / Michael E. DiSanto / Xinhua Zhang -- 3.1. Rho/Rho-Kinase / Michael E. DiSanto / Xinhua Zhang -- 3.2. Rho / Michael E. DiSanto / Xinhua Zhang
Note continued: 3.3. Rho-Kinase / Michael E. DiSanto / Xinhua Zhang -- 3.4. Activation of the Rho/Rho-Kinase Pathway / Xinhua Zhang / Michael E. DiSanto -- 3.5. Effectors of the Rho/Rho-Kinase Pathway / Xinhua Zhang / Michael E. DiSanto -- 4. Rho-Kinase in Dysfunctional Bladder Contractility / Xinhua Zhang / Michael E. DiSanto -- 4.1. Partial Bladder Outlet Obstruction / Michael E. DiSanto / Xinhua Zhang -- 4.2. Diabetic Bladder / Xinhua Zhang / Michael E. DiSanto -- 4.3. Hypertension-Associated Bladder Dysfunction / Xinhua Zhang / Michael E. DiSanto -- 4.4. Hormonal Regulation of Rho-Kinase / Xinhua Zhang / Michael E. DiSanto -- 4.5. The Aging Bladder / Xinhua Zhang / Michael E. DiSanto -- 5. Rho-Kinase in Ureteral Contractility / Xinhua Zhang / Michael E. DiSanto -- 6. Non SM Contractility Effects of Rho-Kinase in the Bladder and Ureter / Michael E. DiSanto / Xinhua Zhang -- 7. Conclusions / Michael E. DiSanto / Xinhua Zhang -- References / Michael E. DiSanto / Xinhua Zhang
Summary The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike
Analysis farmacologie
pharmacology
toxicologie
toxicology
fysiologie
physiology
geneeskunde
medicine
urinestelsel
urinary system
biomedische wetenschappen
biomedicine
Medicine (General)
Geneeskunde (algemeen)
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Urinary organs.
Urinary organs -- Diseases.
Urinary organs -- Abnormalities
Urinary Tract Physiological Phenomena
Urologic Diseases
Urinary Tract
HEALTH & FITNESS -- Diseases -- Genitourinary & STDs.
MEDICAL -- Urology.
Urinary organs
Urinary organs -- Abnormalities
Urinary organs -- Diseases
Form Electronic book
Author Andersson, Karl-Erik
Michel, Martin C., 1959-
ISBN 9783642164996
3642164994
9783642164989
3642164986